{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T08:33:47Z","timestamp":1740126827470,"version":"3.37.3"},"reference-count":18,"publisher":"Georg Thieme Verlag KG","issue":"03","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gesundheitswesen"],"published-print":{"date-parts":[[2023,3]]},"abstract":"<jats:title>Zusammenfassung<\/jats:title><jats:p>\n          Ziel der Studie Ziel des Vorhabens ist die Untersuchung regionaler\n                    Unterschiede in der Konzentration von Thyreoidea-stimulierendem Hormon (TSH),\n                    freiem Thyroxin (fT4) und des Jodstatus in komparablen deutschen und\n                    europ\u00e4ischen Kohortenstudien.<\/jats:p><jats:p>\n          Methodik Die geschlechts- und altersstratifizierten TSH-, fT4- und\n                    Urin-Jodkonzentrationen der anamnestisch schilddr\u00fcsengesunden Teilnehmer\n                    (Altersgruppe 45\u201375 Jahre) der HNR (Heinz Nixdorf Recall) Studie im\n                    Ruhrgebiet Deutschlands, der s\u00fcddeutschen KORA (Kooperative\n                    Gesundheitsforschung in der Region Augsburg) und nordostdeutschen SHIP (Study of\n                    Health in Pomerania) Studie sowie der norwegischen HUNT (Nord-Tr\u00f8ndelag\n                    Health) Studie (Altersgruppe 40\u201379 Jahre), der englischen EPIC (European\n                    Prospective Investigation of Cancer)-Norfolk Studie und der\n                    niederl\u00e4ndischen Rotterdam Studie wurden miteinander verglichen. Der\n                    TSH-Referenzbereich f\u00fcr die HNR Studienpopulation wurde berechnet und\n                    der KORA und SHIP Studie gegen\u00fcbergestellt.<\/jats:p><jats:p>\n          Ergebnisse Regionale Unterschiede zeigten in der Altersgruppe der 45- bis\n                    75- J\u00e4hrigen einen st\u00e4rkeren Einfluss auf die TSH- und\n                    fT4-Konzentrationen als das Geschlecht und das Alter der Probanden. Die\n                    gesch\u00e4tzte Differenz der Mediane, gemessen an der HNR Studie, war mit\n                    \u22120,47 (95% KI: \u22120,53; \u22120,41) f\u00fcr die\n                    M\u00e4nner und \u22120,41 (\u22120,53; \u22120,41) f\u00fcr die\n                    Frauen in der SHIP Studie am geringsten. Die Rotterdam Studie wies sowohl\n                    f\u00fcr M\u00e4nner als auch Frauen die h\u00f6chste Differenz der\n                    Mediane (M\u00e4nner: 0,56 mit 0,44; 0,68 und Frauen: 0,62 mit 0,46; 0,78)\n                    auf. Die geringsten medianen TSH-Konzentrationen wurden, \u00fcber alle\n                    betrachteten Alterskategorien, in den deutschen Kohorten beobachtet.<\/jats:p><jats:p>\n          Schlussfolgerung Der Vergleich der Schilddr\u00fcsenfunktionsparameter\n                    und Jod bei \u00e4lteren Probanden zwischen sechs vergleichbaren\n                    Kohortenstudien aus Deutschland und Europa zeigte einen bedeutenden Einfluss der\n                    Region, welcher die Geschlechts- und Altersabh\u00e4ngigkeit der Parameter\n                    \u00fcberstieg.<\/jats:p>","DOI":"10.1055\/a-1806-0707","type":"journal-article","created":{"date-parts":[[2022,10,4]],"date-time":"2022-10-04T22:55:31Z","timestamp":1664924131000},"page":"175-180","source":"Crossref","is-referenced-by-count":2,"title":["Regionale Unterschiede von Schilddr\u00fcsenfunktionsparametern:\n                    ein Vergleich europ\u00e4ischer Kohortenstudien"],"prefix":"10.1055","volume":"85","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3888-3967","authenticated-orcid":false,"given":"Carolin","family":"Girschik","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philipp","family":"Muchalla","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Endokrinologie, Diabetologie und Stoffwechsel,\n                    Universit\u00e4tsklinikum Essen, Essen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bernd","family":"Kowall","sequence":"additional","affiliation":[{"name":"Institut f\u00fcr Medizinische Informatik, Biometrie und\n                    Epidemiologie, Universit\u00e4tsklinikum Essen, Essen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Denise","family":"Zwanziger","sequence":"additional","affiliation":[{"name":"Zentrallabor \u2013 Bereich Forschung und Lehre, Klinik f\u00fcr\n                    Endokrinologie, Diabetologie und Stoffwechsel, Universit\u00e4tsklinikum\n                    Essen, Essen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raimund","family":"Erbel","sequence":"additional","affiliation":[{"name":"Institut f\u00fcr Medizinische Informatik, Biometrie und\n                    Epidemiologie, Universit\u00e4tsklinikum Essen, Essen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Till","family":"Ittermann","sequence":"additional","affiliation":[{"name":"Institut f\u00fcr Community Medicine, Universit\u00e4tsmedizin\n                    Greifswald, Greifswald, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christa","family":"Meisinger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6363-9061","authenticated-orcid":false,"given":"Andreas","family":"Stang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karl-Heinz","family":"J\u00f6ckel","sequence":"additional","affiliation":[{"name":"Institut f\u00fcr Medizinische Informatik, Biometrie und\n                    Epidemiologie, Universit\u00e4tsklinikum Essen, Essen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dagmar","family":"F\u00fchrer","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Endokrinologie, Diabetologie und Stoffwechsel,\n                    Universit\u00e4tsklinikum Essen, Essen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2022,10,4]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"489","DOI":"10.1210\/jcem.87.2.8182","article-title":"Serum TSH, T(4), and thyroid antibodies in the United States population (1988 to\n                    1994): National Health and Nutrition Examination Survey (NHANES III)","volume":"87","author":"J G Hollowell","year":"2002","journal-title":"The Journal of clinical endocrinology and metabolism"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1186\/1756-6614-5-16","article-title":"The thyroid gland and the process of aging; 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