{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T04:59:04Z","timestamp":1792645144657,"version":"4.5.0"},"reference-count":56,"publisher":"Georg Thieme Verlag KG","issue":"06","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Drug Res (Stuttg)"],"published-print":{"date-parts":[[2022,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Acute kidney injury (AKI) is a major medical challenge caused from renal\n                    ischemia-reperfusion (IR) injury connected with different cellular events in\n                    other distant organs. Renal IR-related oxidative stress and inflammation\n                    followed by cell apoptosis play a crucial role in IR-induced distant organ\n                    pathological damages. Prazosin has shown protective effects against IR-injuries.\n                    Thus, the current study intended to investigate the possible protective role of\n                    prazosin against the consequents of renal IR in the heart and brain tissues. To\n                    reach this goal, rats were randomly divided into 3 groups (n=7): Sham,\n                    IR and prazosin pretreatment-IR animals (1\u2009mg\/kg\n                    intraperitoneally injection of prazosin 45\u2009min before IR induction).\n                    After 6\u2009h reperfusion, lipid peroxidation and antioxidant markers levels\n                    were evaluated in the both, brain and heart tissue. Moreover, apoptotic pathway\n                    in the heart and brain tissues were assessed by western blotting. Accordingly,\n                    prazosin pretreatment in IR model rats could significantly increase the\n                    antioxidant capacity and attenuate apoptotic pathways by increasing the bcl-2\n                    levels and decreasing the expression of Bax and caspase 3 enzymes\n                    (P&lt;0.05). Thus, prazosin suppressed cellular damages of heart and brain\n                    tissues post kidney IR by anti-oxidative and anti-apoptotic effects, which\n                    suggests the plausible use of prazosin in improving the clinical outcomes during\n                    AKI after further investigations.<\/jats:p>","DOI":"10.1055\/a-1806-1453","type":"journal-article","created":{"date-parts":[[2022,4,15]],"date-time":"2022-04-15T00:52:00Z","timestamp":1649983920000},"page":"336-342","source":"Crossref","is-referenced-by-count":11,"title":["Prazosin Treatment Protects Brain and Heart by Diminishing Oxidative\n                    Stress and Apoptotic Pathways After Renal Ischemia Reperfusion"],"prefix":"10.1055","volume":"72","author":[{"given":"Zahra","family":"Malekinejad","sequence":"additional","affiliation":[{"name":"Faculty of Veterinary Medicine, Tabriz Branch, Islamic Azad University,\n                    Tabriz, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shadi","family":"Aghajani","sequence":"additional","affiliation":[{"name":"Faculty of Veterinary Medicine, Tabriz Branch, Islamic Azad University,\n                    Tabriz, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mostafa","family":"Jeddi","sequence":"additional","affiliation":[{"name":"Faculty of Veterinary Medicine, Tabriz Branch, Islamic Azad University,\n                    Tabriz, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reihane","family":"Qahremani","sequence":"additional","affiliation":[{"name":"Tehran University of Medical Science, Tehran, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sina","family":"Shahbazi","sequence":"additional","affiliation":[{"name":"Faculty of Veterinary Medicine, Tabriz Branch, Islamic Azad University,\n                    Tabriz, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasin","family":"Bagheri","sequence":"additional","affiliation":[{"name":"Kidney Research Center, Tabriz University of Medical Sciences, Tabriz,\n                    Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elham","family":"Ahmadian","sequence":"additional","affiliation":[{"name":"Kidney Research Center, Tabriz University of Medical Sciences, Tabriz,\n                    Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2022,4,14]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1038\/nrneph.2013.282","article-title":"Acute kidney injury \u2013 epidemiology, outcomes and economics","volume":"10","author":"O Rewa","year":"2014","journal-title":"Nature reviews nephrology"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"3365","DOI":"10.1681\/ASN.2004090740","article-title":"Acute 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Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/a-1806-1453.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,7,1]],"date-time":"2022-07-01T23:31:33Z","timestamp":1656718293000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/a-1806-1453"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,4,14]]},"references-count":56,"journal-issue":{"issue":"06","published-online":{"date-parts":[[2022,7,1]]},"published-print":{"date-parts":[[2022,7]]}},"URL":"https:\/\/doi.org\/10.1055\/a-1806-1453","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["2194-9379","2194-9387"],"issn-type":[{"value":"2194-9379","type":"print"},{"value":"2194-9387","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,4,14]]}}}