{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,27]],"date-time":"2025-05-27T04:33:02Z","timestamp":1748320382426,"version":"3.37.3"},"reference-count":24,"publisher":"Georg Thieme Verlag KG","issue":"05","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Horm Metab Res"],"published-print":{"date-parts":[[2022,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Work up of adrenal masses includes assessment of endocrine activity and\n                    malignancy risk. There is no indication for surgical removal of nonfunctional\n                    adrenal adenomas, according to the guidelines. In the present study, we aimed at\n                    evaluating the impact of a university endocrine tumor board on the quality of\n                    the indications for adrenal surgery at our institution. One hundred consecutive\n                    patients receiving primary adrenal surgery at the University Hospital of\n                    Cologne, Germany were included. Their demographics, clinic-pathologic\n                    characteristics, treatment and outcome were analyzed. In 55 (55%) cases,\n                    indication for surgery consisted in functional benign tumors, including Conn,\n                    Cushing adenomas and pheochromocytomas. Forty (40%) tumors were referred\n                    to surgery for malignancy suspicion and 5 (5%) myelolipomas were removed\n                    due to their size. Eighty-nine percent of surgeries were performed as minimally\n                    invasive procedures. Overall morbidity included two (2%) self-limiting\n                    pancreatic fistulas after left laparoscopic adrenalectomy for pheochromocytoma.\n                    All functional tumors were confirmed benign by final histology. Only 33\n                    (82.5%) of 40 suspicious cases turned out to be malignant. Consequently,\n                    nonfunctional benign adenomas were \u201cunnecessarily\u201d removed in\n                    only 7 (7%) patients, with 6 (85.7%) of them having a history of\n                    extra-adrenal cancer and all of them fulfilling criteria for surgery, according\n                    to the international guidelines. In conclusion, the endocrine tumor board\n                    provided an excellent adherence to the guidelines with most surgeries being\n                    performed either for functional or malignant tumors. In nonfunctional tumors\n                    with history of extra adrenal cancer, CT guided biopsy might be considered for\n                    obviating surgery.<\/jats:p>","DOI":"10.1055\/a-1808-7239","type":"journal-article","created":{"date-parts":[[2022,5,9]],"date-time":"2022-05-09T22:33:13Z","timestamp":1652135593000},"page":"294-299","source":"Crossref","is-referenced-by-count":3,"title":["Adrenal Surgery in the Era of Multidisciplinary Endocrine Tumor\n                    Boards"],"prefix":"10.1055","volume":"54","author":[{"given":"Costanza","family":"Chiapponi","sequence":"additional","affiliation":[{"name":"Department of General, Visceral, Cancer and Transplant Surgery,\n                    University Hospital Cologne, Cologne, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel Pinto Dos","family":"Santos","sequence":"additional","affiliation":[{"name":"Department of Radiology, University Hospital Cologne, Cologne,\n                    Germany"},{"name":"Department of Radiology, Hospital of the Goethe University Frankfurt,\n                    Frankfurt am Main, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5620-7893","authenticated-orcid":false,"given":"Milan Janis Michael","family":"Hartmann","sequence":"additional","affiliation":[{"name":"Department of General, Visceral, Cancer and Transplant Surgery,\n                    University Hospital Cologne, Cologne, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthias","family":"Schmidt","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, University Hospital Cologne, Cologne,\n                    Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Faust","sequence":"additional","affiliation":[{"name":"Polyclinic for Endocrinology, Diabetes and Preventive Medicine,\n                    University Hospital Cologne, Cologne, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roger","family":"Wahba","sequence":"additional","affiliation":[{"name":"Department of General, Visceral, Cancer and Transplant Surgery,\n                    University Hospital Cologne, Cologne, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christiane Josephine","family":"Bruns","sequence":"additional","affiliation":[{"name":"Department of General, Visceral, Cancer and Transplant Surgery,\n                    University Hospital Cologne, Cologne, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anne Maria","family":"Schultheis","sequence":"additional","affiliation":[{"name":"Department of Pathology, University Hospital Cologne, Cologne,\n                    Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hakan","family":"Alakus","sequence":"additional","affiliation":[{"name":"Department of General, Visceral, Cancer and Transplant Surgery,\n                    University Hospital Cologne, Cologne, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2022,5,9]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"1542","DOI":"10.1056\/NEJMcp2031112","article-title":"Adrenal incidentaloma","volume":"384","author":"E Kebebew","year":"2021","journal-title":"N Engl J Med"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1210\/endrev\/bnaa008","article-title":"Adrenal incidentaloma","volume":"41","author":"M Sherlock","year":"2020","journal-title":"Endocr Rev"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1507\/endocrj.EJ18-0486","article-title":"A nationwide survey of adrenal incidentalomas in Japan: the first report of\n                    clinical and epidemiological features","volume":"67","author":"T Ichijo","year":"2020","journal-title":"Endocr J"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"107","DOI":"10.7326\/M18-3630","article-title":"Natural history of adrenal incidentalomas with and without mild autonomous\n                    cortisol excess. A systematic review and meta-analysis","volume":"171","author":"Y S Elhassan","year":"2019","journal-title":"Ann Intern Med"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"G1","DOI":"10.1530\/EJE-16-0467","article-title":"Management of adrenal incidentalomas: European society of endocrinology clinical\n                    practice guideline in collaboration with the European network for the study of\n                    adrenal tumors","volume":"175","author":"M Fassnacht","year":"2016","journal-title":"Eur J Endocrinol"},{"key":"ref6","first-page":"100073","article-title":"Medicolegal considerations in multidisciplinary cancer care","volume":"1","author":"P L Karas","year":"2020","journal-title":"JTO Clin Res Rep"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/S0169-5002(03)00358-1","article-title":"The pathway study: results of a pilot feasibility study in patients suspected of\n                    having lung carcinoma investigated in a conventional chest clinic setting\n                    compared to a centralised two-stop pathway","volume":"42","author":"P V Murray","year":"2003","journal-title":"Lung Cancer"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1111\/j.1445-5994.2006.01237.x","article-title":"Analysis of multidisciplinary lung cancer practice","volume":"37","author":"M Conron","year":"2007","journal-title":"Intern Med J"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1097\/JTO.0b013e31802bff56","article-title":"Multidisciplinary management of lung cancer: how to test its efficacy?","volume":"2","author":"F Leo","year":"2007","journal-title":"J Thorac Oncol"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1111\/j.1440-1673.2007.01916.x","article-title":"Group decisions in oncology: doctors\u2019 perceptions of the legal\n                    responsibilities arising from multidisciplinary meetings","volume":"52","author":"M A Sidhom","year":"2008","journal-title":"J Med Imaging Radiat Oncol"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ejcts.2010.01.051","article-title":"The effect of a multidisciplinary thoracic malignancy conference on the\n                    treatment of patients with lung cancer","volume":"38","author":"R K Freeman","year":"2010","journal-title":"Eur J Cardio-thoracic Surg"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"5112","DOI":"10.1002\/cncr.26149","article-title":"Do multidisciplinary team meetings make a difference in the management of lung\n                    cancer?","volume":"117","author":"M M Boxer","year":"2011","journal-title":"Cancer"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1007\/s41030-021-00163-8","article-title":"Virtual multidisciplinary tumor boards: a narrative review focused on lung\n                    cancer","volume":"7","author":"V Gebbia","year":"2021","journal-title":"Pulm Ther"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"19.140","DOI":"10.7812\/TPP\/19.140","article-title":"Endocrine tumor board: ten years\u2019 experience of a multidisciplinary\n                    clinical working conference","volume":"24","author":"A Savitz","year":"2020","journal-title":"Perm J"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.amjsurg.2021.07.013","article-title":"Influence of endocrine multidisciplinary tumor board on patient management and\n                    treatment decision making","volume":"223","author":"S Kelley","year":"2022","journal-title":"Am J Surg"},{"key":"ref16","first-page":"53","article-title":"Die dorsale retroperitoneoskopische Adrenalektomie \u2013 eine neue operative\n                    Technik [Dorsal retroperitoneoscopic adrenalectomy \u2013 a new surgical\n                    technique]","volume":"120","author":"M K Walz","year":"1995","journal-title":"Zentralbl Chir"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"2629","DOI":"10.1245\/s10434-012-2352-0","article-title":"A comparative study of the transperitoneal and posterior retroperitoneal\n                    approaches for laparoscopic adrenalectomy for adrenal tumors","volume":"19","author":"C R Lee","year":"2012","journal-title":"Ann Surg Oncol"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1159\/000505788","article-title":"Adrenal tumors: are gender aspects relevant?","volume":"36","author":"P F Alesina","year":"2020","journal-title":"Visc Med"},{"key":"ref19","first-page":"448","article-title":"EUROCRINE\u00ae: adrenal surgery 2015\u20132019 \u2013 surprising\n                    initial results","volume":"92","author":"J I Staubitz","year":"2021","journal-title":"Der Chir"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"200","DOI":"10.3803\/EnM.2017.32.2.200","article-title":"Clinical guidelines for the management of adrenal incidentaloma","volume":"32","author":"J M Lee","year":"2017","journal-title":"Endocrinol Metab"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1530\/EJE-21-0650","article-title":"Adrenal wash-out CT: moderate diagnostic value in distinguishing benign from\n                    malignant adrenal masses","volume":"186","author":"W Schloetelburg","year":"2022","journal-title":"Eur J Endocrinol"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1016\/S2213-8587(20)30218-7","article-title":"Urine steroid metabolomics for the differential diagnosis of adrenal\n                    incidentalomas in the EURINE-ACT study: a prospective test validation study","volume":"8","author":"I Bancos","year":"2020","journal-title":"Lancet Diabetes Endocrinol"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"36271","DOI":"10.21037\/gs.2020.03.04","article-title":"Not all adrenal incidentalomas require biochemical testing to exclude\n                    pheochromocytoma: Mayo clinic experience and a meta-analysis","volume":"9","author":"L M Gruber","year":"2020","journal-title":"Gland Surg"},{"key":"ref24","first-page":"1","article-title":"Management of adrenal incidentaloma: the role of adrenalectomy may be\n                    underestimated","volume":"16","author":"Y L Ye","year":"2016","journal-title":"BMC Surg"}],"container-title":["Hormone and Metabolic Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/a-1808-7239.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,5,9]],"date-time":"2022-05-09T22:35:04Z","timestamp":1652135704000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/a-1808-7239"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,5]]},"references-count":24,"journal-issue":{"issue":"05","published-online":{"date-parts":[[2022,5,9]]},"published-print":{"date-parts":[[2022,5]]}},"URL":"https:\/\/doi.org\/10.1055\/a-1808-7239","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["0018-5043","1439-4286"],"issn-type":[{"type":"print","value":"0018-5043"},{"type":"electronic","value":"1439-4286"}],"subject":[],"published":{"date-parts":[[2022,5]]}}}