{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,4,5]],"date-time":"2024-04-05T14:21:41Z","timestamp":1712326901063},"reference-count":69,"publisher":"Georg Thieme Verlag KG","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Laryngorhinootologie"],"abstract":"<jats:title>Zusammenfassung<\/jats:title><jats:p>Die Anzahl der gemeldeten Syphilis-F\u00e4lle steigt seit Jahren an. Die sexuell \u00fcbertragbare Erkrankung wird durch die Spiroch\u00e4te Treponema pallidum Subspezies pallidum verursacht und verl\u00e4uft hierbei in verschiedenen Stadien. In allen Stadien k\u00f6nnen hierbei Symptome im HNO-Bereich auftreten. Hierdurch ist bei passenden Symptomen eine Syphilis-Infektion als Differenzialdiagnose vom HNO-Arzt stets zu bedenken. So ist bei zunehmendem oralem Geschlechtsverkehr der Prim\u00e4raffekt\/harter Schanker zunehmend h\u00e4ufig im Mundraum zu beobachten. Zudem k\u00f6nnen Symptome nicht nur im Mundraum, sondern auch im Bereich des Ohrs, der Nase, des Larynx sowie auch zervikal und fazial auftreten. Die Diagnose wird hierbei \u00fcber den direkten Erregernachweis oder \u00fcber einen serologischen Nachweis gesichert. Die Spiroch\u00e4te ist nicht kultivierbar. Der therapeutische Goldstandard ist die Gabe von Benzathin-Penicillin G oder Procain-Penicillin G. Als Alternative stehen Doxycyclin, Makrolide oder Ceftriaxon zur Verf\u00fcgung. Bei einer Innenohr- oder Hirnnervenbeteiligung ist die zus\u00e4tzliche Gabe eines Glukokortikoids zu empfehlen. Vor Durchf\u00fchrung der antibiotischen Therapie ist der Patient \u00fcber die M\u00f6glichkeit einer Jarisch-Herxheimer-Reaktion aufzukl\u00e4ren. Bei einer Syphilis-Infektion ist stets eine kollegiale Zusammenarbeit mit den Venerologen zu empfehlen, sodass eine effektive und umfassende Diagnostik und Therapie erfolgen kann.<\/jats:p>","DOI":"10.1055\/a-1808-7321","type":"journal-article","created":{"date-parts":[[2022,4,8]],"date-time":"2022-04-08T22:40:32Z","timestamp":1649457632000},"source":"Crossref","is-referenced-by-count":1,"title":["Syphilisinfektion im HNO-Bereich"],"prefix":"10.1055","author":[{"given":"Inga Marte Charlott","family":"Seuthe","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Hals-, Nasen-, Ohrenheilkunde, Kopf- und Halschirurgie, Lehrstuhl f\u00fcr Hals-Nasen-Ohrenheilkunde der Universit\u00e4t Witten\/Herdecke, St-Josefs-Hospital Hagen, Katholisches Krankenhaus Hagen gem. 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