{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T22:39:58Z","timestamp":1789079998784,"version":"build-2803163510"},"reference-count":30,"publisher":"Georg Thieme Verlag KG","issue":"02","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Tierarztl Prax Ausg G Grosstiere Nutztiere"],"published-print":{"date-parts":[[2022,4]]},"abstract":"<jats:title>Zusammenfassung<\/jats:title><jats:p>Gegenstand und Ziel K\u00fche mit Labmagenulkus und Reticuloperitonitis traumatica (RPT) weisen zum Teil \u00e4hnliche Laborbefunde auf. Das Ziel der vorliegenden Untersuchung war es, die H\u00e4ufigkeit der individuellen Laborparameter bei K\u00fchen mit Reticuloperitonitis traumatica, Labmagenulkus Typ 1 (U1), Typ 2 (U2), Typ 3 (U3), Typ 4 (U4) und Typ 5 (U5) miteinander zu vergleichen und die diagnostische Zuverl\u00e4ssigkeit der verschiedenen Parameter zu berechnen.<\/jats:p><jats:p>Material und Methoden Die Untersuchungen wurden an 182 gesunden Kontrollk\u00fchen (Kontrollen), 503\u2005K\u00fchen mit RPT, 94 mit U1, 145 mit U2, 60 mit U3, 87 mit U4 und 14 mit U5 durchgef\u00fchrt. Ausgewertet wurden H\u00e4matokrit, Leukozytenzahl, Gesamtprotein, Fibrinogen, Harnstoff, Kalium, Chlorid, Basenabweichung und Pansenchlorid. Die H\u00e4ufigkeitsverteilungen aller Parameter wurden f\u00fcr die gesunden Kontrollk\u00fche und die 6\u2005Krankheitsgruppen miteinander verglichen. Danach wurden f\u00fcr alle Parameter die Zuverl\u00e4ssigkeitsparameter (diagnostische Sensitivit\u00e4t, diagnostische Spezifit\u00e4t, pr\u00e4diktive Werte, positive Likelihood Ratio [LR+]) berechnet.<\/jats:p><jats:p>Ergebnisse Au\u00dferhalb der Referenzbereiche liegende Laborwerte kamen je nach Parameter in 2 bis 24\u2005% der F\u00e4lle auch bei gesunden K\u00fchen vor (Pansenchlorid 2\u2005%, Harnstoff 6\u2005%, Serumchlorid 11\u2005%, H\u00e4matokrit 13\u2005%, Basenabweichung 18\u2005%, Fibrinogen 20\u2005%, Gesamteiwei\u00df 21\u2005%, Gesamtleukozytenzahl 22\u2005%, Kalium 24\u2005%) und erschwerten so die Differenzierung zwischen \u00abgesund\u00bb und \u00abkrank\u00bb. Am besten eigneten sich f\u00fcr die Differenzierung das Pansenchlorid und der Serumharnstoff, da beide Parameter nur in 2 bzw. 6\u2005% der gesunden K\u00fche ver\u00e4ndert waren. Dies wurde auch unterst\u00fctzt durch eine LR+ von 14 bis 27 f\u00fcr eine Pansenchloridkonzentration\u2005&gt;\u200530\u2005mmol\/l und eine Serumharnstoffkonzentration\u2005&gt;\u20056,5\u2005mmol\/l bei K\u00fchen mit Labmagenulzera. Die Serumharnstoffkonzentration wies auch eine hohe diagnostische Spezifit\u00e4t auf und war wie die Pansenchloridkonzentration zur Differenzierung zwischen gesunden und kranken K\u00fchen geeignet. Die Harnstoffkonzentration lag nur bei 0,5\u2005% der Kontrollk\u00fche\u2005&gt;\u20058,5\u2005mmol\/l und die LR+ f\u00fcr eine Harnstoffkonzentration\u2005&gt;\u20058,5\u2005mmol\/l variierte zwischen 11 bei K\u00fchen mit RPT und 128 bei K\u00fchen mit U2. Mit Ausnahme der RPT-K\u00fche trat eine Azot\u00e4mie bei kranken K\u00fchen signifikant h\u00e4ufiger als bei gesunden auf. K\u00fche mit U2 wiesen mit 70\u2005% der F\u00e4lle signifikant h\u00e4ufiger Harnstoffkonzentrationen\u2005&gt;\u20058,5\u2005mmol\/l als die K\u00fche aller anderen Gruppen auf. Obschon sich die H\u00e4ufigkeiten abnormer Parameter zwischen den Krankheitsgruppen in vielen F\u00e4llen signifikant unterschieden, konnten keine Parameter zu deren zuverl\u00e4ssigen Differenzierung eruiert werden.<\/jats:p><jats:p>Schlussfolgerung Einzelbefunde eignen sich nicht, um zwischen verschiedenen Krankheiten zu differenzieren.<\/jats:p><jats:p>Klinische Relevanz F\u00fcr die Diagnose der RPT und der Labmagenulzera der Typen 1 bis 5 ist die Gesamtheit aller Laborwerte unter Einbezug der klinischen Befunde, eines ausf\u00fchrlichen Vorberichts und oft auch weiterer Befunde wie z.\u2005B. des Haubenr\u00f6ntgens, der Sonographie und der Bauchh\u00f6hlenpunktion erforderlich. In vielen F\u00e4llen kann eine sichere Diagnose erst bei der Laparotomie bzw. der Sektion korrekt gestellt werden.<\/jats:p>","DOI":"10.1055\/a-1809-1042","type":"journal-article","created":{"date-parts":[[2022,5,6]],"date-time":"2022-05-06T22:34:47Z","timestamp":1651876487000},"page":"91-100","source":"Crossref","is-referenced-by-count":3,"title":["H\u00e4ufigkeit und diagnostische Zuverl\u00e4ssigkeit von Laborbefunden bei K\u00fchen mit Reticuloperitonitis traumatica und Labmagengeschw\u00fcren"],"prefix":"10.1055","volume":"50","author":[{"given":"Ueli","family":"Braun","sequence":"additional","affiliation":[{"name":"Departement f\u00fcr Nutztiere, Vetsuisse-Fakult\u00e4t, Universit\u00e4t Z\u00fcrich"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karl","family":"Nuss","sequence":"additional","affiliation":[{"name":"Departement f\u00fcr Nutztiere, Vetsuisse-Fakult\u00e4t, Universit\u00e4t Z\u00fcrich"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carina","family":"Oschlies","sequence":"additional","affiliation":[{"name":"Departement f\u00fcr Nutztiere, Vetsuisse-Fakult\u00e4t, Universit\u00e4t Z\u00fcrich"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christina","family":"Reif","sequence":"additional","affiliation":[{"name":"Departement f\u00fcr Nutztiere, Vetsuisse-Fakult\u00e4t, Universit\u00e4t Z\u00fcrich"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sonja","family":"Warislohner","sequence":"additional","affiliation":[{"name":"Departement f\u00fcr Nutztiere, Vetsuisse-Fakult\u00e4t, Universit\u00e4t Z\u00fcrich"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Gerspach","sequence":"additional","affiliation":[{"name":"Departement f\u00fcr Nutztiere, Vetsuisse-Fakult\u00e4t, Universit\u00e4t 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