{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,25]],"date-time":"2025-11-25T11:23:05Z","timestamp":1764069785170,"version":"3.45.0"},"reference-count":39,"publisher":"Georg Thieme Verlag KG","issue":"02","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Tierarztl Prax Ausg K Kleintiere Heimtiere"],"published-print":{"date-parts":[[2022,4]]},"abstract":"<jats:title>Zusammenfassung<\/jats:title>\n                  <jats:p>Gegenstand und Ziel In dieser Studie wurde der Einsatz des jodhaltigen Kontrastmittels (KM) Amidotrizoat an gesunden und an Kaninchen mit einer Magendilatation und einem Verdacht auf eine intestinale Obstruktion untersucht. Dazu wurden die Passagezeiten durch den Magendarmtrakt und der klinische Einsatz innerhalb eines Jahres untersucht. Au\u00dferdem wurde ein m\u00f6glicher Einfluss auf Schilddr\u00fcsenhormone evaluiert.<\/jats:p>\n                  <jats:p>Material und Methoden Die KM-Passagezeiten durch die einzelnen Darmabschnitte wurden an 14 gesunden Kaninchen r\u00f6ntgenologisch untersucht. Dazu wurden 7 ml\/kg einer L\u00f6sung mit 300 mg Iod\/ml und 600 mg Amidotrizoat\/ml verabreicht und die Tiere in zeitlichen Abst\u00e4nden erneut ger\u00f6ntgt. Zur Untersuchung der Schilddr\u00fcsenhormone (TT4, fT4, TSH) wurden 3 verschiedene Dosierungen (D1 2 ml\/kg, D2 7 ml\/kg, D3 10 ml\/kg) verabreicht und an 2 Zeitpunkten (60 min, 24 h) Blutproben entnommen. Au\u00dferdem wurden innerhalb eines Jahres 70 Kaninchen, die wegen einer Magendilatation und dem Verdacht einer Obstruktion das Kontrastmittel Amidotrizoat erhalten hatten, mit Augenmerk auf den Nachweis von Kontrastmittel im Z\u00e4kum, Laborver\u00e4nderungen und Mortalit\u00e4ten retrospektiv ausgewertet<\/jats:p>\n                  <jats:p>Ergebnisse Bei allen gesunden Kaninchen war im Mittel nach 45\u201360 min Kontrastmittel im Z\u00e4kum nachweisbar. Bei den erkrankten Tieren zeigte sich dies im Mittel nach 121,2 min. Diese Patienten wiesen zu 92,4 % eine Hypothermie, zu 45,9 % eine Hyperglyk\u00e4mie, zu 56,1 % eine Erh\u00f6hung von Harnstoff und zu 33,9 % eine Erh\u00f6hung des Kreatinins auf. 71,4 % konnten medikament\u00f6s versorgt werden, wobei 12 % dieser F\u00e4lle letal verliefen. 28,6 % chirurgisch versorgte Kaninchen wiesen eine Mortalit\u00e4t von 50 % auf. Die TT4-\n          , fT4-\n           und TSH-Bestimmungen ergaben unter allen 3 Dosierungen signifikante Abweichungen (p &lt; 0,05). Die Werte erwiesen sich bei einer Kontrolluntersuchung 2 Wochen sp\u00e4ter als transient.<\/jats:p>\n                  <jats:p>Schlussfolgerung und klinische Relevanz Bei Verdacht eines Ileus beim Kaninchen kann neben dem Einsatz von nativen R\u00f6ntgenaufnahmen Amidotrizoat f\u00fcr die Bewertung des Krankheitsverlaufs hilfreich sein. Eine Kontrolle der Nierenfunktion und eine Hydrierung des Tieres sind anzuraten. Es konnten transiente Ver\u00e4nderungen der Schilddr\u00fcsenhormone nachgewiesen werden, die aber ohne klinische Relevanz blieben.<\/jats:p>","DOI":"10.1055\/a-1810-9885","type":"journal-article","created":{"date-parts":[[2022,5,6]],"date-time":"2022-05-06T18:32:09Z","timestamp":1651861929000},"page":"112-123","source":"Crossref","is-referenced-by-count":1,"title":["Untersuchungen zum Einsatz des jodhaltigen Kontrastmittels Amidotrizoes\u00e4ure beim Kaninchen (Oryctolagus cuniculus)"],"prefix":"10.1055","volume":"50","author":[{"given":"Julie-Ann","family":"Dierig","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Heimtiere, Reptilien und V\u00f6gel, Stiftung Tier\u00e4rztliche Hochschule Hannover"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Fehr","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Heimtiere, Reptilien und V\u00f6gel, Stiftung Tier\u00e4rztliche Hochschule Hannover"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ina","family":"Leiter","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Rinder, Endokrinologisches Labor, Stiftung Tier\u00e4rztliche Hochschule Hannover"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maximilian","family":"Reuschel","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Heimtiere, Reptilien und V\u00f6gel, Stiftung Tier\u00e4rztliche Hochschule Hannover"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2022,5,6]]},"reference":[{"volume-title":"Kontrastmittel: \u00dcbersicht, Anwendung und pharmazeutische Aspekte","year":"2013","author":"U Speck","key":"ref1"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1055\/s-0044-100993","article-title":"R\u00f6ntgenbildinterpretation Magen-Darm-Trakt Kaninchen","volume":"21","author":"J Hein","year":"2018","journal-title":"Kleintier Konkret"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"409","DOI":"10.1136\/vr.161.12.409","article-title":"Gastric dilation and intestinal obstruction in 76 rabbits","volume":"161","author":"F M Harcourt-Brown","year":"2007","journal-title":"Vet Rec"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"484","DOI":"10.1136\/vr.102491","article-title":"Medical treatment of 145 cases of gastric dilatation in rabbits","volume":"175","author":"B Schuhmann","year":"2014","journal-title":"Vet Rec"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"174","DOI":"10.1016\/B978\u20130-323\u201348435\u20130.00014\u20139","volume-title":"Gastrointestinal Diseases of Rabbits","author":"B L Oglesbee","year":"2020","edition":"4. 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