{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,11,6]],"date-time":"2024-11-06T05:29:47Z","timestamp":1730870987554,"version":"3.28.0"},"reference-count":43,"publisher":"Georg Thieme Verlag KG","issue":"05","funder":[{"name":"Talent Development Foundation of Minhang District, Shanghai."}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Neurol Surg A Cent Eur Neurosurg"],"published-print":{"date-parts":[[2024,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n          Background\u2003Anterior cervical corpectomy and fusion (ACCF) has been widely used in the treatment of cervical spondylotic myelopathy (CSM), ossification of posterior longitudinal ligament (OPLL), cervical trauma, and other cervical diseases, but few studies have reported the osseous and physiologic remodeling of the anterior wall of the spinal canal following ACCF. In this study, we analyze that remodeling process and its influence on titanium mesh cage (TMC) subsidence.<\/jats:p><jats:p>\n          Methods\u2003We performed a clinical and radiologic analysis of consecutive patients treated with ACCF. Growth rates (GRs) reflecting the extent of remodeling of the remnants of the resected vertebral bodies were measured. We compared the computed tomography (CT) scans taken immediately and at least 1 year after surgery, and a literature review was conducted.<\/jats:p><jats:p>\n          Results\u2003In all, 48 patients underwent ACCF at a mean age of 61.5\u2009\u00b1\u200912.0 years. The median follow-up was 36 months, and 159 CT images were analyzed. The GR values of the remnants of the vertebral bodies on CT images immediately and 1 year after surgery were 0.505\u2009\u00b1\u20090.077 and 0.650\u2009\u00b1\u20090.022 (p\u2009&lt;\u20090.001), respectively, and the GR value at \u22654 years was 1. Axial CT scans showed that remodeling starts from the lateral remnants of the resected vertebral bodies, finally reaching the center. When fusion of the vertebral bodies and the titanium cage was complete during the first year after ACCF, osteogenesis and remodeling were initiated in the osseous anterior wall of the spinal canal. The remodeling of the osseous anterior wall of the spinal canal was completed at the fourth year after surgery, without recompressing the spinal cord, as seen on both axial and lateral CT scans. According to the literature review, there was no TMC subsidence at more than 4 years after surgery.<\/jats:p><jats:p>\n          Conclusion\u2003The anterior wall of the spinal canal undergoes osseous remodeling after ACCF. The process is complete in the fourth year after surgery and prevents TMC subsidence.<\/jats:p>","DOI":"10.1055\/a-1812-9834","type":"journal-article","created":{"date-parts":[[2022,3,30]],"date-time":"2022-03-30T22:48:33Z","timestamp":1648680513000},"page":"464-471","source":"Crossref","is-referenced-by-count":0,"title":["Physiologic Osseous Remodeling of the Anterior Wall of the Spinal Canal after Anterior Cervical Corpectomy and Fusion: A Retrospective Observational Study"],"prefix":"10.1055","volume":"85","author":[{"given":"Haofei","family":"Ni","sequence":"first","affiliation":[{"name":"Department of Orthopaedics, The Fifth People's Hospital of Shanghai, Fudan University, Shanghai, China"},{"name":"Department of Spinal Surgery, Tongji University School of Medicine, Tongji Hospital, Shanghai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Mao","sequence":"first","affiliation":[{"name":"Department of Orthopaedics, The Fifth People's Hospital of Shanghai, Fudan University, Shanghai, China"},{"name":"Department of Orthopaedic Surgery, Yangpu Hospital, School of Medicine, Tongji University, Shanghai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hailong","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics, The Fifth People's Hospital of Shanghai, Fudan University, Shanghai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Youhai","family":"Dong","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics, The Fifth People's Hospital of Shanghai, Fudan University, Shanghai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2023,9,13]]},"reference":[{"issue":"22","key":"ref1","doi-asserted-by":"crossref","first-page":"2493","DOI":"10.1097\/01.brs.0000145412.93407.c3","article-title":"Results of surgical treatment for degenerative cervical myelopathy: anterior cervical corpectomy and stabilization","volume":"29","author":"K Sevki","year":"2004","journal-title":"Spine"},{"issue":"08","key":"ref2","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1097\/00007632-200404150-00005","article-title":"Enhancement of stability following anterior cervical corpectomy: a biomechanical study","volume":"29","author":"K Singh","year":"2004","journal-title":"Spine"},{"issue":"03","key":"ref3","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1097\/00005373-198003000-00002","article-title":"Anterior plate stabilization for fracture-dislocations of the lower cervical spine","volume":"20","author":"J B\u00f6hler","year":"1980","journal-title":"J Trauma"},{"issue":"394","key":"ref4","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1097\/00003086-200201000-00006","article-title":"The use of titanium mesh cages in the cervical spine","author":"K D Riew","year":"2002","journal-title":"Clin Orthop Relat Res"},{"issue":"01","key":"ref5","first-page":"23","article-title":"Anterior cervical reconstruction using titanium mesh cages","volume":"19","author":"S Shams","year":"2007","journal-title":"J Ayub Med Coll Abbottabad"},{"issue":"05","key":"ref6","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1016\/j.surneu.2005.12.021","article-title":"Efficacy and safety of the use of titanium mesh cages and anterior cervical plates for interbody fusion after anterior cervical corpectomy","volume":"65","author":"H C Chuang","year":"2006","journal-title":"Surg Neurol"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"6398","DOI":"10.12659\/MSM.910269","article-title":"Anterior cervical corpectomy and fusion and anterior cervical discectomy and fusion using titanium mesh cages for treatment of degenerative cervical pathologies: a literature review","volume":"24","author":"Z Wen","year":"2018","journal-title":"Med Sci Monit"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.clineuro.2018.11.015","article-title":"A comparison of long-term outcomes of nanohydroxyapatite\/polyamide-66 cage and titanium mesh cage in anterior cervical corpectomy and fusion: a clinical follow-up study of least 8 years","volume":"176","author":"B Hu","year":"2019","journal-title":"Clin Neurol Neurosurg"},{"issue":"119","key":"ref9","first-page":"231","article-title":"A roentgenographic evaluation of frozen allografts versus autografts in anterior cervical spine fusions","author":"M D Brown","year":"1976","journal-title":"Clin Orthop Relat Res"},{"issue":"24","key":"ref10","doi-asserted-by":"crossref","first-page":"1994","DOI":"10.1097\/BRS.0b013e31825c0130","article-title":"Utility of postoperative radiographs for cervical spine fusion: a comprehensive evaluation of operative technique, surgical indication, and duration since surgery","volume":"37","author":"D N Shau","year":"2012","journal-title":"Spine"},{"issue":"01","key":"ref11","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1007\/s00586-016-4888-3","article-title":"The application of a new type of titanium mesh cage in hybrid anterior decompression and fusion technique for the treatment of continuously three-level cervical spondylotic myelopathy","volume":"26","author":"X Liu","year":"2017","journal-title":"Eur Spine J"},{"issue":"05","key":"ref12","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1007\/s00402-010-1181-5","article-title":"Anterior hybrid decompression and segmental fixation for adjacent three-level cervical spondylosis","volume":"131","author":"Q Guo","year":"2011","journal-title":"Arch Orthop Trauma Surg"},{"issue":"10","key":"ref13","doi-asserted-by":"crossref","first-page":"1369","DOI":"10.1007\/s00402-011-1317-2","article-title":"Anterior corpectomy and reconstruction with titanium mesh cage and dynamic cervical plate for cervical spondylotic myelopathy in elderly osteoporosis patients","volume":"131","author":"D Yan","year":"2011","journal-title":"Arch Orthop Trauma Surg"},{"issue":"12","key":"ref14","doi-asserted-by":"crossref","first-page":"2891","DOI":"10.1007\/s00586-013-2976-1","article-title":"Evaluation of a new type of titanium mesh cage versus the traditional titanium mesh cage for single-level, anterior cervical corpectomy and fusion","volume":"22","author":"Y Fengbin","year":"2013","journal-title":"Eur Spine J"},{"issue":"04","key":"ref15","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1227\/NEU.0b013e318282a558","article-title":"Radiological outcomes of static vs expandable titanium cages after corpectomy: a retrospective cohort analysis of subsidence","volume":"72","author":"D Lau","year":"2013","journal-title":"Neurosurgery"},{"issue":"12","key":"ref16","doi-asserted-by":"crossref","first-page":"2421","DOI":"10.1007\/s00264-013-2101-4","article-title":"Comparison of anterior cervical fusion by titanium mesh cage versus nano-hydroxyapatite\/polyamide cage following single-level corpectomy","volume":"37","author":"X Yang","year":"2013","journal-title":"Int Orthop"},{"issue":"24","key":"ref17","doi-asserted-by":"crossref","first-page":"E1511","DOI":"10.1097\/BRS.0b013e3182a6427a","article-title":"Clinical outcome of spinal reconstruction after total en bloc spondylectomy at 3 or more levels","volume":"38","author":"K Yoshioka","year":"2013","journal-title":"Spine"},{"issue":"05","key":"ref18","doi-asserted-by":"crossref","first-page":"e96265","DOI":"10.1371\/journal.pone.0096265","article-title":"Evaluation of anterior cervical reconstruction with titanium mesh cages versus nano-hydroxyapatite\/polyamide66 cages after 1- or 2-level corpectomy for multilevel cervical spondylotic myelopathy: a retrospective study of 117 patients","volume":"9","author":"Y Zhang","year":"2014","journal-title":"PLoS One"},{"key":"ref19","first-page":"8026362","article-title":"Cerebrospinal fluid pulsation stress promotes the angiogenesis of tissue-engineered laminae","volume":"2020","author":"L Li","year":"2020","journal-title":"Stem Cells Int"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1089\/ten.tea.2018.0100","article-title":"The role of continuous cerebrospinal fluid pulsation stress in the remodeling of artificial vertebral laminae: a comparison experiment","volume":"25","author":"L Li","year":"2018","journal-title":"Tissue Eng Part A"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"1082","DOI":"10.1089\/ten.tea.2017.0426","article-title":"Biological and mechanical factors promote the osteogenesis of rabbit artificial vertebral laminae: a comparison study","volume":"24","author":"L Li","year":"2018","journal-title":"Tissue Eng Part A"},{"issue":"21","key":"ref22","doi-asserted-by":"crossref","first-page":"E1300","DOI":"10.1097\/BRS.0b013e3182a3cbb3","article-title":"Tissue-engineered bone formation in vivo for artificial laminae of the vertebral arch using \u03b2-tricalcium phosphate bioceramics seeded with mesenchymal stem cells","volume":"38","author":"Y Dong","year":"2013","journal-title":"Spine"},{"issue":"08","key":"ref23","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1097\/BRS.0b013e31822ecebc","article-title":"Construction of artificial laminae of the vertebral arch using bone marrow mesenchymal stem cells transplanted in collagen sponge","volume":"37","author":"Y Dong","year":"2012","journal-title":"Spine"},{"issue":"04","key":"ref24","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1089\/ten.teb.2009.0687","article-title":"The early fracture hematoma and its potential role in fracture healing","volume":"16","author":"P Kolar","year":"2010","journal-title":"Tissue Eng Part B Rev"},{"key":"ref25","first-page":"863421","article-title":"Mechanotransduction in musculoskeletal tissue regeneration: effects of fluid flow, loading, and cellular-molecular pathways","volume":"2014","author":"Y X Qin","year":"2014","journal-title":"BioMed Res Int"},{"issue":"02","key":"ref26","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1007\/s12195-014-0329-8","article-title":"Hydraulic pressure during fluid flow regulates purinergic signaling and cytoskeleton organization of osteoblasts","volume":"7","author":"J D Gardinier","year":"2014","journal-title":"Cell Mol Bioeng"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1038\/bonekey.2012.221","article-title":"Role of mathematical modeling in bone fracture healing","volume":"1","author":"P Pivonka","year":"2012","journal-title":"Bonekey Rep"},{"issue":"02","key":"ref28","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1517\/14712598.2016.1118458","article-title":"Platelet-rich plasma for bone healing and regeneration","volume":"16","author":"A Oryan","year":"2016","journal-title":"Expert Opin Biol Ther"},{"issue":"05","key":"ref29","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1007\/s12015-016-9665-5","article-title":"Stem cells in bone regeneration","volume":"12","author":"G G Walmsley","year":"2016","journal-title":"Stem Cell Rev Rep"},{"issue":"02","key":"ref30","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1080\/09537104.2017.1327656","article-title":"Platelet concentrates for bone regeneration: current evidence and future challenges","volume":"29","author":"Z Badran","year":"2018","journal-title":"Platelets"},{"issue":"04","key":"ref31","doi-asserted-by":"crossref","first-page":"2937","DOI":"10.1002\/jcp.26042","article-title":"The roles of signaling pathways in bone repair and regeneration","volume":"233","author":"M Majidinia","year":"2018","journal-title":"J Cell Physiol"},{"issue":"04","key":"ref32","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1002\/cbf.3027","article-title":"From mechanical stimulation to biological pathways in the regulation of stem cell fate","volume":"32","author":"N Shah","year":"2014","journal-title":"Cell Biochem Funct"},{"issue":"02","key":"ref33","doi-asserted-by":"crossref","first-page":"139","DOI":"10.2165\/00007256-200838020-00004","article-title":"Mechanotransduction in human bone: in vitro cellular physiology that underpins bone changes with exercise","volume":"38","author":"A Scott","year":"2008","journal-title":"Sports Med"},{"issue":"05","key":"ref34","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1016\/j.semcdb.2008.07.004","article-title":"Bone remodeling during fracture repair: the cellular picture","volume":"19","author":"A Schindeler","year":"2008","journal-title":"Semin Cell Dev Biol"},{"issue":"04","key":"ref35","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1302\/0301-620X.89B4.18301","article-title":"The anabolic and catabolic responses in bone repair","volume":"89","author":"D G Little","year":"2007","journal-title":"J Bone Joint Surg Br"},{"issue":"19","key":"ref36","doi-asserted-by":"crossref","first-page":"E551","DOI":"10.1097\/BRS.0b013e31814614f3","article-title":"How does the ossification area of the posterior longitudinal ligament thicken following cervical laminoplasty?","volume":"32","author":"T Hori","year":"2007","journal-title":"Spine"},{"issue":"12","key":"ref37","doi-asserted-by":"crossref","first-page":"1798","DOI":"10.2106\/00004623-200112000-00005","article-title":"Progression of ossification of the posterior longitudinal ligament following en bloc cervical laminoplasty","volume":"83","author":"Y Kawaguchi","year":"2001","journal-title":"J Bone Joint Surg Am"},{"issue":"04","key":"ref38","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1097\/00007632-198107000-00005","article-title":"Operative results and postoperative progression of ossification among patients with ossification of cervical posterior longitudinal ligament","volume":"6","author":"K Hirabayashi","year":"1981","journal-title":"Spine"},{"issue":"03","key":"ref39","first-page":"271","article-title":"Radiological study of cervical ossification of the posterior longitudinal ligament","volume":"12","author":"T Takatsu","year":"1999","journal-title":"J Spinal Disord"},{"issue":"05","key":"ref40","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1097\/BRS.0b013e31821f4a51","article-title":"Five-year follow-up evaluation of surgical treatment for cervical myelopathy caused by ossification of the posterior longitudinal ligament: a prospective comparative study of anterior decompression and fusion with floating method versus laminoplasty","volume":"37","author":"K Sakai","year":"2012","journal-title":"Spine"},{"issue":"12","key":"ref41","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1097\/BRS.0000000000001933","article-title":"Are there differences in the progression of ossification of the posterior longitudinal ligament following laminoplasty versus fusion?: a meta-analysis","volume":"42","author":"C H Lee","year":"2017","journal-title":"Spine"},{"issue":"07","key":"ref42","doi-asserted-by":"crossref","first-page":"1116","DOI":"10.1016\/j.spinee.2017.10.069","article-title":"Radiological risk factors for progression of ossification of posterior longitudinal ligament following laminoplasty","volume":"18","author":"D H Lee","year":"2018","journal-title":"Spine J"},{"issue":"05","key":"ref43","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1007\/s00223-002-0021-1","article-title":"Uni-axial cyclic stretch induces Cbfa1 expression in spinal ligament cells derived from patients with ossification of the posterior longitudinal ligament","volume":"74","author":"K Iwasaki","year":"2004","journal-title":"Calcif Tissue Int"}],"container-title":["Journal of Neurological Surgery Part A: Central European Neurosurgery"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/a-1812-9834.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,5]],"date-time":"2024-11-05T16:18:44Z","timestamp":1730823524000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/a-1812-9834"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,3,30]]},"references-count":43,"journal-issue":{"issue":"05","published-online":{"date-parts":[[2024,7,26]]},"published-print":{"date-parts":[[2024,9]]}},"URL":"https:\/\/doi.org\/10.1055\/a-1812-9834","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["2193-6315","2193-6323"],"issn-type":[{"type":"print","value":"2193-6315"},{"type":"electronic","value":"2193-6323"}],"subject":[],"published-other":{"date-parts":[[2022,3,30]]},"published":{"date-parts":[[2022,3,30]]}}}