{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T08:33:31Z","timestamp":1740126811165,"version":"3.37.3"},"reference-count":57,"publisher":"Georg Thieme Verlag KG","issue":"05","funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["81600601"],"award-info":[{"award-number":["81600601"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100002855","name":"Ministry of Science and Technology of the People's Republic of China","doi-asserted-by":"crossref","award":["2020ZX09201-018"],"award-info":[{"award-number":["2020ZX09201-018"]}],"id":[{"id":"10.13039\/501100002855","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Horm Metab Res"],"published-print":{"date-parts":[[2022,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Abstract Nonalcoholic fatty liver disease (NAFLD) and chronic kidney disease\n                    (CKD) share common pathogenic mechanisms and risk factors. We aim to evaluate\n                    the association between NAFLD and CKD in a non-diabetic gouty population. The\n                    retrospective cross sectional study was performed on 1049 non-diabetic gouty\n                    participants, who were hospitalized between 2014 and 2020, across 4 districts in\n                    Shandong, China. Demographic and clinical characteristics of the study\n                    population were collected. The odds ratios (OR) and corresponding 95%\n                    confidence intervals (CI) about the NAFLD severity determined by ultrasonography\n                    were obtained by multiple logistic regression analysis. An unexpectedly inverse\n                    relationship was found between NAFLD severity and the risk of CKD in people with\n                    gout. Multivariate logistic regression analysis demonstrated that a higher\n                    degree of NAFLD severity is independently associated with a lower risk of CKD in\n                    people with gout, after adjusted for age, sex, smoking, gout duration, and\n                    metabolic risk factors including obesity, hypertension, hyperglycemia,\n                    hyperuricemia, and dyslipidemia, with OR 0.392 (95% CI\n                    0.248\u20130.619, p&lt;0.001), 0.379 (95% CI\n                    0.233\u20130.616, p&lt;0.001) and 0.148 (95% CI\n                    0.043\u20130.512, p=0.003) in participants with mild, moderate, and\n                    severe NAFLD, respectively, compared to those without NAFLD. We also observed a\n                    weakened association of serum uric acid (SUA) with metabolic risk factors and\n                    NAFLD under circumstances of CKD in people with gout (r=\u20130.054,\n                    p=0.466). In conclusion, the presence and severity of NAFLD were\n                    negatively associated with the risk of CKD in the non-diabetic gouty\n                    population.<\/jats:p>","DOI":"10.1055\/a-1815-7559","type":"journal-article","created":{"date-parts":[[2022,4,4]],"date-time":"2022-04-04T22:55:57Z","timestamp":1649112957000},"page":"325-334","source":"Crossref","is-referenced-by-count":1,"title":["The Negative Association Between NAFLD Severity and CKD in a\n                    Non-Diabetic Gouty Population"],"prefix":"10.1055","volume":"54","clinical-trial-number":[{"clinical-trial-number":"chictr2000035185","registry":"10.18810\/chictr"}],"author":[{"given":"Yajing","family":"Huang","sequence":"additional","affiliation":[{"name":"Endocrinology and Metabolism, The Affiliated Hospital of Qingdao\n                    University, Qingdao, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yue","family":"Zhou","sequence":"additional","affiliation":[{"name":"Endocrinology and Metabolism, Fudan University, Shanghai,\n                    China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yahao","family":"Wang","sequence":"additional","affiliation":[{"name":"Endocrinology and Metabolism, Fudan University, Shanghai,\n                    China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jingwei","family":"Chi","sequence":"additional","affiliation":[{"name":"Endocrinology and Metabolism, The Affiliated Hospital of Qingdao\n                    University, Qingdao, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenshan","family":"Lv","sequence":"additional","affiliation":[{"name":"Endocrinology and Metabolism, The Affiliated Hospital of Qingdao\n                    University, Qingdao, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yangang","family":"Wang","sequence":"additional","affiliation":[{"name":"Endocrinology and Metabolism, The Affiliated Hospital of Qingdao\n                    University, Qingdao, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ying","family":"Chen","sequence":"additional","affiliation":[{"name":"Endocrinology, The Affiliated Hospital of Qingdao University, Qingdao,\n                    China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2022,5,9]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1093\/rheumatology\/kes211","article-title":"Gout and its comorbidities: implications for therapy","volume":"52","author":"L K Stamp","year":"2013","journal-title":"Rheumatology (Oxford)"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1038\/nrrheum.2015.91","article-title":"Global epidemiology of gout: prevalence, incidence and risk factors","volume":"11","author":"C F Kuo","year":"2015","journal-title":"Nat Rev Rheumatol"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"F471","DOI":"10.1152\/ajprenal.00560.2012","article-title":"Uric acid-induced phenotypic transition of renal tubular cells as a novel\n                    mechanism of chronic kidney disease","volume":"304","author":"E S Ryu","year":"2013","journal-title":"Am J Physiol Renal Physiol"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"1465","DOI":"10.1111\/j.1523-1755.2004.00909.x","article-title":"Uric acid and the state of the intrarenal renin-angiotensin system in\n                    humans","volume":"66","author":"T S Perlstein","year":"2004","journal-title":"Kidney Int"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"1204","DOI":"10.1681\/ASN.2007101075","article-title":"Uric acid and incident kidney disease in the community","volume":"19","author":"D E Weiner","year":"2008","journal-title":"J Am Soc Nephrol"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1186\/s13075-015-0610-9","article-title":"Gout and risk of chronic kidney disease and nephrolithiasis: meta-analysis of\n                    observational studies","volume":"17","author":"M Roughley","year":"2015","journal-title":"Arthritis Res Ther"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"R83","DOI":"10.1186\/ar3806","article-title":"Risk of end-stage renal disease associated with gout: a nationwide population\n                    study","volume":"14","author":"K Yu","year":"2012","journal-title":"Arthritis Res Ther"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"e5","DOI":"10.1053\/j.ajkd.2016.11.006","article-title":"AJKD atlas of renal pathology: gouty nephropathy","volume":"69","author":"M A Lusco","year":"2017","journal-title":"Am J Kidney Dis"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1161\/hy1101.092839","article-title":"Elevated uric acid increases blood pressure in the rat by a novel\n                    crystal-independent mechanism","volume":"38","author":"M Mazzali","year":"2001","journal-title":"Hypertension"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"1287","DOI":"10.1161\/01.HYP.0000072820.07472.3B","article-title":"Uric acid stimulates monocyte chemoattractant protein-1 production in vascular\n                    smooth muscle cells via mitogen-activated protein kinase and\n                    cyclooxygenase-2","volume":"41","author":"J Kanellis","year":"2003","journal-title":"Hypertension"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1007\/s11892-018-0985-5","article-title":"Does Altered uric acid metabolism contribute to diabetic kidney disease\n                    pathophysiology?","volume":"18","author":"A Gul","year":"2018","journal-title":"Curr Diab Rep"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1053\/j.ajkd.2014.05.019","article-title":"CKD and nonalcoholic fatty liver disease","volume":"64","author":"G Targher","year":"2014","journal-title":"Am J Kidney Dis"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"1830","DOI":"10.2337\/dc15-1182","article-title":"Fatty liver and chronic kidney disease: novel mechanistic insights and\n                    therapeutic opportunities","volume":"39","author":"G Musso","year":"2016","journal-title":"Diabetes Care"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1016\/j.jhep.2020.01.013","article-title":"NAFLD as a driver of chronic kidney disease","volume":"72","author":"C D Byrne","year":"2020","journal-title":"J Hepatol"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1007\/s40620-020-00751-y","article-title":"Therapeutic implications of shared mechanisms in non-alcoholic fatty liver\n                    disease and chronic kidney disease","volume":"34","author":"M Kanbay","year":"2020","journal-title":"J Nephrol"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1186\/s12876-020-01278-z","article-title":"Association between NAFLD and risk of prevalent chronic kidney disease: why\n                    there is a difference between east and west?","volume":"20","author":"M Zhang","year":"2020","journal-title":"BMC Gastroenterol"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.jfma.2019.02.010","article-title":"The correlation between fatty liver disease and chronic kidney disease","volume":"119","author":"P C Chen","year":"2020","journal-title":"J Formos Med Assoc"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"1635","DOI":"10.3390\/jcm9061635","article-title":"Association between non-alcoholic fatty liver disease and chronic kidney\n                    disease: a cross-sectional study","volume":"9","author":"T Akahane","year":"2020","journal-title":"J Clin Med"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1007\/s00125-007-0897-4","article-title":"Non-alcoholic fatty liver disease is independently associated with an increased\n                    prevalence of chronic kidney disease and proliferative\/laser-treated\n                    retinopathy in type 2 diabetic patients","volume":"51","author":"G Targher","year":"2008","journal-title":"Diabetologia"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1111\/j.1445-5994.2009.01979.x","article-title":"Impact of non-alcoholic fatty liver disease on microalbuminuria in patients with\n                    prediabetes and diabetes","volume":"40","author":"S T Hwang","year":"2010","journal-title":"Intern Med J"},{"key":"ref21","first-page":"29","volume":"76","author":"P Richette","year":"2017","journal-title":"2016 updated EULAR evidence-based recommendations for the management\n                    of gout"},{"key":"ref22","first-page":"1","article-title":"Obesity: preventing and managing the global epidemic. Report of a WHO\n                    consultation","volume":"894","author":"WHO","year":"2000","journal-title":"World Health Organ Tech Rep Ser"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1007\/BF00280883","article-title":"Homeostasis model assessment: insulin resistance and beta-cell function from\n                    fasting plasma glucose and insulin concentrations in man","volume":"28","author":"D R Matthews","year":"1985","journal-title":"Diabetologia"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1038\/ki.2010.462","article-title":"Evaluation of the chronic kidney disease epidemiology collaboration equation for\n                    estimating the glomerular filtration rate in multiple ethnicities","volume":"79","author":"L A Stevens","year":"2011","journal-title":"Kidney Int"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1053\/j.ajkd.2014.01.416","article-title":"KDOQI US commentary on the 2012 KDIGO clinical practice guideline for the\n                    evaluation and management of CKD","volume":"63","author":"L A Inker","year":"2014","journal-title":"Am J Kidney Dis"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"1274","DOI":"10.1016\/j.jhep.2017.08.024","article-title":"Development of chronic kidney disease in patients with non-alcoholic fatty liver\n                    disease: a cohort study","volume":"67","author":"D H Sinn","year":"2017","journal-title":"J Hepatol"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1016\/j.molmed.2015.08.005","article-title":"Emerging liver-kidney interactions in nonalcoholic fatty liver disease","volume":"21","author":"G Musso","year":"2015","journal-title":"Trends Mol Med"},{"key":"ref28","first-page":"1203","article-title":"Common and unique factors and the bidirectional relationship between chronic\n                    kidney disease and nonalcoholic fatty liver in type 2 diabetes patients","volume":"13","author":"Y J Lee","year":"2020"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"6858","DOI":"10.1073\/pnas.78.11.6858","article-title":"Uric acid provides an antioxidant defense in humans against oxidant- and\n                    radical-caused aging and cancer: a hypothesis","volume":"78","author":"B N Ames","year":"1981","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"9748","DOI":"10.1073\/pnas.85.24.9748","article-title":"Antioxidant defenses and lipid peroxidation in human blood plasma[J]","volume":"85","author":"B Frei","year":"1988","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.abb.2004.03.006","article-title":"Biomarkers of antioxidant capacity in the hydrophilic and lipophilic\n                    compartments of human plasma","volume":"430","author":"K J Yeum","year":"2004","journal-title":"Arch Biochem Biophys"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1111\/sdi.12735","article-title":"The physiology of uric acid and the impact of end-stage kidney disease and\n                    dialysis","volume":"32","author":"M Murea","year":"2019","journal-title":"Semin Dial"},{"key":"ref34","first-page":"37","article-title":"Free radical scavenging, DNA protection, and inhibition of lipid peroxidation\n                    mediated by uric acid","volume":"35","author":"B Stinefelt","year":"2005","journal-title":"Ann Clin Lab Sci"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1016\/0891-5849(93)90143-I","article-title":"Towards the physiological function of uric acid","volume":"14","author":"B F Becker","year":"1993","journal-title":"Free Radic Biol Med"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/j.atherosclerosis.2009.04.012","article-title":"Acute, food-induced moderate elevation of plasma uric acid protects against\n                    hyperoxia-induced oxidative stress and increase in arterial stiffness in healthy\n                    humans","volume":"207","author":"J Vukovic","year":"2009","journal-title":"Atherosclerosis"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1042\/bj2350747","article-title":"Uric acid-iron ion complexes. A new aspect of the antioxidant functions of uric\n                    acid","volume":"235","author":"K J Davies","year":"1986","journal-title":"Biochem J"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1016\/j.numecd.2007.02.011","article-title":"Uric acid and oxidative stress: relative impact on cardiovascular risk?","volume":"17","author":"P Strazzullo","year":"2007","journal-title":"Nutr Metab Cardiovasc Dis"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"S3","DOI":"10.1097\/HJH.0000000000001330","article-title":"Association between serum uric acid and cardiovascular mortality and all-cause\n                    mortality: a cohort study","volume":"35","author":"E Cheong","year":"2017","journal-title":"J Hypertens"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"123","DOI":"10.2174\/1570161114666161021110013","article-title":"Lipoprotein subfractions, uric acid and cardiovascular risk in end-stage renal\n                    disease (ESRD) patients","volume":"15","author":"A Gluba-Brzozka","year":"2017","journal-title":"Curr Vasc Pharmacol"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.1016\/j.jhep.2008.11.021","article-title":"Association of serum uric acid level with non-alcoholic fatty liver disease: a\n                    cross-sectional study","volume":"50","author":"Y Li","year":"2009","journal-title":"J Hepatol"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"930","DOI":"10.1111\/1440-1681.12011","article-title":"Renal function-dependent association of serum uric acid with metabolic syndrome\n                    and hepatic fat content in a middle-aged and elderly Chinese population","volume":"39","author":"M F Xia","year":"2012","journal-title":"Clin Exp Pharmacol Physiol"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1016\/j.amjmed.2005.03.043","article-title":"Serum uric acid and cardiovascular disease: recent developments, and where do\n                    they leave us?","volume":"118","author":"J F Baker","year":"2005","journal-title":"Am J Med"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"2508","DOI":"10.1161\/CIRCULATIONAHA.106.651117","article-title":"High-dose allopurinol improves endothelial function by profoundly reducing\n                    vascular oxidative stress and not by lowering uric acid","volume":"114","author":"J George","year":"2006","journal-title":"Circulation"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1016\/S0272-6386(12)80995-4","article-title":"Gouty arthritis in end-stage renal disease: clinical course and rarity of new\n                    cases","volume":"23","author":"O Ifudu","year":"1994","journal-title":"Am J Kidney Dis"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"706","DOI":"10.2169\/internalmedicine.44.706","article-title":"Frequency of gouty arthritis in patients with end-stage renal disease in\n                    Japan","volume":"44","author":"I Ohno","year":"2005","journal-title":"Intern Med"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1093\/ndt\/15.5.644","article-title":"Reduced secretion of proinflammatory cytokines of monosodium urate\n                    crystal-stimulated monocytes in chronic renal failure: an explanation for\n                    infrequent gout episodes in chronic renal failure patients?","volume":"15","author":"O Schreiner","year":"2000","journal-title":"Nephrol Dial Transplant"},{"key":"ref48","first-page":"815","article-title":"Xanthine oxidase inhibition attenuates insulin resistance and diet-induced\n                    steatohepatitis in mice","volume":"10","author":"T Nishikawa","year":"2020"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"G42","DOI":"10.1152\/ajpgi.00443.2014","article-title":"The xanthine oxidase inhibitor febuxostat suppresses development of nonalcoholic\n                    steatohepatitis in a rodent model","volume":"309","author":"Y Nakatsu","year":"2015","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"1835","DOI":"10.1016\/j.lfs.2004.10.031","article-title":"Selectivity of febuxostat, a novel non-purine inhibitor of xanthine\n                    oxidase\/xanthine dehydrogenase","volume":"76","author":"Y Takano","year":"2005","journal-title":"Life Sci"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1053\/j.ajkd.2017.09.026","article-title":"Update on anemia in ESRD and earlier stages of CKD: core curriculum 2018","volume":"71","author":"S Fishbane","year":"2008","journal-title":"Am J Kidney Dis"},{"key":"ref52","first-page":"1182","volume":"61","author":"C Kim","year":"2012","journal-title":"Serum ferritin levels predict incident non-alcoholic fatty liver\n                    disease in healthy Korean men"},{"key":"ref53","first-page":"931","volume":"122","author":"F Facchini","year":"2002","journal-title":"Effect of iron depletion in carbohydrate-intolerant patients with\n                    clinical evidence of nonalcoholic fatty liver disease"},{"key":"ref54","first-page":"3002","volume":"20","author":"L Valenti","year":"2014","journal-title":"A randomized trial of iron depletion in patients with nonalcoholic\n                    fatty liver disease and hyperferritinemia"},{"key":"ref55","first-page":"1555","volume":"61","author":"L Adams","year":"2015","journal-title":"The impact of phlebotomy in nonalcoholic fatty liver disease: a\n                    prospective, randomized, controlled trial"},{"key":"ref56","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.3390\/nu11051123","article-title":"Do transferrin levels predict haemodialysis adequacy in patients with end-stage\n                    renal disease?","volume":"11","author":"G Tarantino","year":"2019","journal-title":"Nutrients"},{"key":"ref57","first-page":"5582","volume":"282","author":"L Chen","year":"2007","journal-title":"Iron causes interactions of TAK1, p21ras, and phosphatidylinositol\n                    3-kinase in caveolae to activate IkappaB kinase in hepatic\n                    macrophages"},{"key":"ref58","first-page":"887","article-title":"Ferritin functions as a proinflammatory cytokine via iron-independent protein\n                    kinase C zeta\/nuclear factor kappaB-regulated signaling in rat hepatic\n                    stellate cells","volume":"49","author":"R Ruddell","year":"2009"}],"container-title":["Hormone and Metabolic Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/a-1815-7559.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,8,10]],"date-time":"2022-08-10T10:26:34Z","timestamp":1660127194000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/a-1815-7559"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,4,4]]},"references-count":57,"journal-issue":{"issue":"05","published-online":{"date-parts":[[2022,5,9]]},"published-print":{"date-parts":[[2022,5]]}},"URL":"https:\/\/doi.org\/10.1055\/a-1815-7559","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["0018-5043","1439-4286"],"issn-type":[{"type":"print","value":"0018-5043"},{"type":"electronic","value":"1439-4286"}],"subject":[],"published-other":{"date-parts":[[2022,4,4]]},"published":{"date-parts":[[2022,4,4]]}}}