{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,6,16]],"date-time":"2025-06-16T19:08:00Z","timestamp":1750100880403,"version":"3.37.3"},"reference-count":18,"publisher":"Georg Thieme Verlag KG","issue":"05","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Klin Padiatr"],"published-print":{"date-parts":[[2023,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n          Backround Aim of the present study is to evaluate the feasibility and\n                    reliability of an smartphone application for monitore of bilirubin levels in\n                    preterm infants.<\/jats:p><jats:p>\n          Methods Preterm infants hospitalized in the neonatal intensive care unit\n                    with gestational age of&lt;35 weeks were included. Exclusion criteria were\n                    parental reluctance and requirement of phototherapy in the last\n                    12\u2009hours. Measurements were obtained through a smartphone application\n                    (BiliScan) along with simultaneous transcutaneous device (Dr\u00e4ger JM 105)\n                    and venous blood biochemistry.<\/jats:p><jats:p>\n          Results Mean gestational age was 30.8\u00b12.4 weeks and birth weight\n                    was 1622\u00b1566\u2009g. Measurements were obtained at a median of 4\n                    (1\u201321) days of life. Twenty-five infants (19.4%) had ABO\n                    and\/or Rh incompatibility and 39 infants (30.2%) required\n                    phototherapy. None of the cases required exchange transfusion. Mean total serum\n                    bilirubin (TSB) level was 8.16\u00b12.60\u2009mg\/dL, mean\n                    transcutaneous bilirubin (TcB) level was\n                    8.60\u00b12.70\u2009mg\/dL, and the mean bilirubin level measured\n                    by BiliScan was 7.26\u00b12.68\u2009mg\/dL. For TSB and TcB\n                    measurements, the intraclass correlation coefficient (ICC) was found to be 0.915\n                    (95% confidence interval 0.835\u20130.951; p&lt;0.001) and a\n                    strong positive correlation was found between these two measurements. When TSB\n                    and BiliScan measurements were compared, ICC was found to be significant as\n                    0.512 (95% confidence interval 0.353\u20130.638; p&lt;0.001),\n                    with a moderate correlation.<\/jats:p><jats:p>\n          Conclusions In this study, we evaluated the feasibility and reliability of\n                    a smartphone application for monitoring bilirubin levels in preterm infants.\n                    Although BiliScan measurements reported to display high correlation in term\n                    infants, a moderate correlation was found in the preterm infants. It is an\n                    emerging low-cost, non-invasive alternative for neonatal jaundice monitoring,\n                    however, results should be interpreted with caution in preterm infants.<\/jats:p>","DOI":"10.1055\/a-1816-5878","type":"journal-article","created":{"date-parts":[[2022,12,21]],"date-time":"2022-12-21T00:22:05Z","timestamp":1671582125000},"page":"265-269","source":"Crossref","is-referenced-by-count":1,"title":["Bilirubin Measurement Through a Smartphone Application in Preterm\n                    Infants"],"prefix":"10.1055","volume":"235","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1440-3754","authenticated-orcid":false,"given":"Huseyin","family":"Ustun","sequence":"additional","affiliation":[{"name":"Neonatology, Tepecik Training and Research Hospital Clinics, Konak,\n                    Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mehmet Yekta","family":"Oncel","sequence":"additional","affiliation":[{"name":"Neonatology, Izmir Katip Celebi Universitesi, Izmir, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Melike","family":"Kefeli","sequence":"additional","affiliation":[{"name":"Neonatology, Izmir Tepecik Training and Research Hospital, Konak,\n                    Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Melek","family":"Akar","sequence":"additional","affiliation":[{"name":"Neonatology, Izmir Tepecik Training and Research Hospital, Konak,\n                    Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Defne","family":"Eng\u00fcr","sequence":"additional","affiliation":[{"name":"Neonatology, Izmir Tepecik Training and Research Hospital, Konak,\n                    Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2022,12,20]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"2532","DOI":"10.1111\/apa.15287","article-title":"Bilirubin estimates from smartphone images of newborn infants\u2019 skin\n                    correlated highly to serum bilirubin levels","volume":"109","author":"A Aune","year":"2020","journal-title":"Acta Paediatrica"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"e016050","DOI":"10.1136\/bmjopen-2017-016050","article-title":"Term admissions to neonatal units in England: a role for transitional care? A\n                    retrospective cohort study","volume":"7","author":"C Battersby","year":"2017","journal-title":"BMJ Open"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1038\/pr.2013.208","article-title":"Neonatal hyperbilirubinemia and Rhesus disease of the newborn: incidence and\n                    impairment estimates for 2010 at regional and global levels","volume":"74","author":"V K Bhutani","year":"2013","journal-title":"Pediatr Res"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1111\/j.1440-1754.2007.01062.x","article-title":"Prediction of severe hyperbilirubinaemia using the Bilicheck transcutaneous\n                    bilirubinometer","volume":"43","author":"N-Y Boo","year":"2007","journal-title":"J Paediatr Child Health [Internet]"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1542\/peds.2011-2586","article-title":"Limitations and Opportunities of Transcutaneous Bilirubin Measurements","volume":"129","author":"N Bosschaart","year":"2012","journal-title":"Pediatrics."},{"key":"ref7","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1056\/NEJM200102223440807","article-title":"Neonatal hyperbilirubinemia","volume":"344","author":"P A Dennery","year":"2001","journal-title":"N Engl J Med"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1542\/peds.2014-2388","article-title":"Early discharge of infants and risk of readmission for jaundice","volume":"135","author":"S J Lain","year":"2015","journal-title":"Pediatrics"},{"key":"ref9","first-page":"199","article-title":"The neurological sequelae of neonatal hyperbilirubinemia: definitions, diagnosis\n                    and treatment of the kernicterus spectrum disorders (KSDs)","volume":"13","author":"J B Le Pichon","year":"2017","journal-title":"Curr Pediatr Rev"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"4529","DOI":"10.1364\/BOE.6.004529","article-title":"Screening neonatal jaundice based on the sclera color of the eye using digital\n                    photography","volume":"6","author":"T S Leung","year":"2015","journal-title":"Biomed Opt Express"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"e293","DOI":"10.1542\/neo.21-5-e293","article-title":"Neonatal management during the coronavirus disease (COVID-19) outbreak: the\n                    Chinese experience","volume":"21","author":"X Ma","year":"2020","journal-title":"NeoReviews"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"1193","DOI":"10.1542\/peds.2009-0329","article-title":"Hyperbilirubinemia in the newborn infant>or=35 weeks\u2019\n                    gestation: an update with clarifications","volume":"124","author":"M J Maisels","year":"2009","journal-title":"Pediatrics."},{"key":"ref13","doi-asserted-by":"crossref","first-page":"e0197938","DOI":"10.1371\/journal.pone.0197938","article-title":"The smartphone camera as a potential method for transcutaneous bilirubin\n                    measurement","volume":"13","author":"S B Munkholm","year":"2018","journal-title":"PloS one"},{"key":"ref15","first-page":"e84397.","article-title":"Detection of neonatal jaundice by using an android OS-based smartphone\n                    application","volume":"29","author":"P Padidar","year":"2019","journal-title":"Iranian Journal of Pediatrics"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"782","DOI":"10.1016\/j.jpeds.2007.11.003","article-title":"Is visual assessment of jaundice reliable as a screening tool to detect\n                    significant neonatal hyperbilirubinemia?","volume":"152","author":"A Riskin","year":"2008","journal-title":"J Pediatr"},{"key":"ref17","first-page":"597","article-title":"Evaluation of an automatic image-based screening technique for neonatal\n                    hyperbilirubinemia","volume":"54","author":"Z H Rong","year":"2016","journal-title":"Zhonghua Er Ke Za Zhi"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1542\/peds.2014-1919","article-title":"Better Outcomes through Research for Newborns Network. Discrepancies between\n                    transcutaneous and serum bilirubin measurements","volume":"135","author":"J A Taylor","year":"2015","journal-title":"Pediatrics."},{"key":"ref20","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/S0140-6736(08)60106-3","article-title":"Clinical signs that predict severe illness in children under age 2 months: a\n                    multicentre study","volume":"371","year":"2008","journal-title":"Lancet"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"2021","DOI":"10.1056\/NEJMra1308124","article-title":"Bilirubin-induced neurologic damage \u2013 mechanism and management\n                    approaches","volume":"369","author":"J F Watchko","year":"2013","journal-title":"N Engl J Med"}],"container-title":["Klinische P\u00e4diatrie"],"original-title":[],"language":"de","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/a-1816-5878.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,4]],"date-time":"2023-09-04T23:29:29Z","timestamp":1693870169000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/a-1816-5878"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,12,20]]},"references-count":18,"journal-issue":{"issue":"05","published-online":{"date-parts":[[2023,9,4]]},"published-print":{"date-parts":[[2023,9]]}},"URL":"https:\/\/doi.org\/10.1055\/a-1816-5878","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["0300-8630","1439-3824"],"issn-type":[{"type":"print","value":"0300-8630"},{"type":"electronic","value":"1439-3824"}],"subject":[],"published":{"date-parts":[[2022,12,20]]}}}