{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T09:07:58Z","timestamp":1785229678511,"version":"3.55.0"},"reference-count":34,"publisher":"Georg Thieme Verlag KG","issue":"03","funder":[{"name":"the State Key Project for Liver Cancer","award":["2017ZX10203205-001-002"],"award-info":[{"award-number":["2017ZX10203205-001-002"]}]},{"name":"the State Key Project for Liver Cancer","award":["2012ZX10002017-004"],"award-info":[{"award-number":["2012ZX10002017-004"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Z Gastroenterol"],"published-print":{"date-parts":[[2023,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Background The current meta-analysis was conducted to determine whether antithrombotic drug use would affect the diagnostic accuracy of fecal occult blood testing for advanced colorectal neoplasia.<\/jats:p>\n                  <jats:p>Methods Articles published between 2000 and 2019 were systematically retrieved and screened according to the inclusion and exclusion criteria by two reviewers independently. Pooled analyses were conducted with a fixed-effect model if no apparent heterogeneity (I2 \u2265 50%) was found between studies; otherwise, the random effects model would be used. Sensitivity analysis and subgroup analysis were also conducted using Review Manager 5.3.<\/jats:p>\n                  <jats:p>Results Pooled analysis revealed that aspirin and nonsteroidal anti-inflammatory drugs were associated with a decrease in the positive predictive value of fecal occult blood testing for advanced colorectal neoplasia screening, with a RR of 0.89 (95% CI: 0.84\u20130.94) and 0.88 (95% CI: 0.84\u20130.93, p&lt;0.001) respectively. Subgroup analysis based on data limited to high-quality studies, fecal immunochemical testing, or in Caucasians also showed that the use of aspirin\/NSAID drugs decreased the accuracy for advanced colorectal neoplasia screening.<\/jats:p>\n                  <jats:p>Conclusion Aspirin\/NSAIDs and direct oral anticoagulants rather than warfarin may decrease the diagnostic accuracy of fecal occult blood testing for advanced colorectal neoplasia screening.<\/jats:p>","DOI":"10.1055\/a-1817-3925","type":"journal-article","created":{"date-parts":[[2022,5,17]],"date-time":"2022-05-17T19:06:21Z","timestamp":1652814381000},"page":"297-306","source":"Crossref","is-referenced-by-count":1,"title":["Impact of antithrombotic drugs on the accuracy of fecal occult blood testing for advanced colorectal neoplasia screening: a meta-analysis and systematic review"],"prefix":"10.1055","volume":"61","author":[{"given":"Shu-jie","family":"Pang","sequence":"first","affiliation":[{"name":"Eastern Hepatobiliary Surgery Hospital, Second Military Medical University, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhi-peng","family":"Lin","sequence":"first","affiliation":[{"name":"Department of Hepatobiliary Surgery, The 940th Hospital of PLA Joint Logistics Support Force, Lanzhou, China"},{"name":"Eastern Hepatobiliary Surgery Hospital, Second Military Medical University, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhe","family":"Sun","sequence":"first","affiliation":[{"name":"Eastern Hepatobiliary Surgery Hospital, Second Military Medical University, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Zhang","sequence":"first","affiliation":[{"name":"Tongji Hospital, School of Medicine, Tongji University, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhen-gang","family":"Yuan","sequence":"additional","affiliation":[{"name":"Eastern Hepatobiliary Surgery Hospital, Second Military Medical University, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ning","family":"Yang","sequence":"additional","affiliation":[{"name":"Eastern Hepatobiliary Surgery Hospital, Second Military Medical University, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2022,5,17]]},"reference":[{"key":"ref1","first-page":"145","article-title":"Colorectal cancer statistics, 2020","volume":"70","author":"RL Siegel","year":"2020","journal-title":"CA Cancer J Clin"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"713","DOI":"10.1038\/s41575-019-0189-8","article-title":"Global burden of colorectal cancer: emerging trends, risk factors and prevention strategies","volume":"16","author":"N Keum","year":"2019","journal-title":"Nat Rev Gastroenterol 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