{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T23:06:27Z","timestamp":1790291187185,"version":"4.1.0"},"reference-count":10,"publisher":"Georg Thieme Verlag KG","issue":"08","license":[{"start":{"date-parts":[[2022,4,7]],"date-time":"2022-04-07T00:00:00Z","timestamp":1649289600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Endosc Int Open"],"published-print":{"date-parts":[[2022,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n          Background and study aims\u2002Endoscopic ultrasound-guided gallbladder drainage (EUS-GBD) is the preferred treatment for patients with acute calculous cholecystitis who are unfit for surgery. The aim of this study was to perform a cost-effective analysis (CEA) comparing EUS-GBD with percutaneous gallbladder drainage (PT-GBD).<\/jats:p><jats:p>\n          Patients and methods\u2002CEA was performed on patients recruited for our prior randomized controlled trial. A budget impact model was developed to compare the base-case and scenario of EUS-GBD applications. The costs including peri-procedure and intra-procedure, reinterventions, expenses associated with treatment of adverse events (AEs), costs of hospital stay, subsequent clinic follow-up, and unplanned readmission were included.<\/jats:p><jats:p>\n          Results\u2002PT-GBD had a lower total procedure cost per patient (USD$4,375.00) than EUS-GBD (USD$9,397.44). For EUS-GBD, the cost of cautery-enhanced lumen-apposing stent accounted for the major part of the expense (USD$4,910.26). EUS-GBD resulted in a lower expected cost (USD$108.26 vs USD$1,601.54) for a re-procedure. The expected cost per patient in unplanned readmissions in the EUS-GBD group (USD$450.00) was lower than that in the PT-GBD group (USD$1,717.56). Based on the budget impact analysis, the net budget impact per year of introducing EUS-GBD to replace PT-GBD was higher (USD$16,424.10 vs USD$11,433.08). The net budget impact was most sensitive to the cost of stent and linear echoendoscope used in EUS-GBD.<\/jats:p><jats:p>\n          Conclusions\u2002The net budget impact per year was higher for introducing EUS-GBD. The cost of the stent accounted for the major cost difference between the two procedures. EUS-GBD saved on the cost in management of AEs, reinterventions, and unplanned readmissions but these did not offset the cost of the stent.<\/jats:p>","DOI":"10.1055\/a-1819-8124","type":"journal-article","created":{"date-parts":[[2022,4,7]],"date-time":"2022-04-07T22:45:07Z","timestamp":1649371507000},"page":"E1073-E1079","source":"Crossref","is-referenced-by-count":15,"title":["Impact of endoscopic ultrasound-guided gallbladder drainage on reducing costs of reintervention and unplanned readmission: a budget impact analysis"],"prefix":"10.1055","volume":"10","clinical-trial-number":[{"clinical-trial-number":"nct02212717","registry":"10.18810\/clinical-trials-gov"}],"author":[{"given":"Shannon Melissa","family":"Chan","sequence":"first","affiliation":[{"name":"Department of Surgery, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, Hong Kong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc Ka Chun","family":"Chong","sequence":"first","affiliation":[{"name":"Jockey Club School of Public Health and Primary Care, Faculty of Medicine, Chinese University of Hong Kong, Hong Kong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip Wai Yan","family":"Chiu","sequence":"additional","affiliation":[{"name":"Department of Surgery, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, Hong Kong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enders Kwok Wai","family":"Ng","sequence":"additional","affiliation":[{"name":"Department of Surgery, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, Hong Kong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin Chi Sang","family":"Wong","sequence":"additional","affiliation":[{"name":"Jockey Club School of Public Health and Primary Care, Faculty of Medicine, Chinese University of Hong Kong, Hong Kong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony Yuen Bun","family":"Teoh","sequence":"additional","affiliation":[{"name":"Department of Surgery, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, Hong Kong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2022,8,15]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"1085","DOI":"10.1136\/gutjnl-2019-319996","article-title":"Endosonography-guided gallbladder drainage versus percutaneous cholecystostomy in very high-risk surgical patients with acute cholecystitis: an international randomised multicentre controlled superiority trial (DRAC 1)","volume":"69","author":"A YB Teoh","year":"2020","journal-title":"Gut"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"722","DOI":"10.1055\/a-0929-6603","article-title":"Endoscopic ultrasound-guided gallbladder drainage versus percutaneous cholecystostomy for high risk surgical patients with acute cholecystitis: a systematic review and meta-analysis","volume":"51","author":"S W Luk","year":"2019","journal-title":"Endoscopy"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1016\/j.gie.2020.09.040","article-title":"Comparison of EUS-guided endoscopic transpapillary and percutaneous gallbladder drainage for acute cholecystitis: a systematic review with network meta-analysis","volume":"93","author":"A Podboy","year":"2021","journal-title":"Gastrointest Endosc"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"1904","DOI":"10.1007\/s00464-020-07409-7","article-title":"EUS-guided versus endoscopic transpapillary gallbladder drainage in high-risk surgical patients with acute cholecystitis: a systematic review and meta-analysis","volume":"34","author":"R Krishnamoorthi","year":"2020","journal-title":"Surg Endosc"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1055\/a-1020-3932","article-title":"Endoscopic ultrasound-guided gallbladder drainage, transpapillary drainage, or percutaneous drainage in high risk acute cholecystitis patients: a systematic review and comparative meta-analysis","volume":"52","author":"B P Mohan","year":"2020","journal-title":"Endoscopy"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"738","DOI":"10.1016\/j.cgh.2016.12.021","article-title":"Similar efficacies of endoscopic ultrasound gallbladder drainage with a lumen-apposing metal stent versus percutaneous transhepatic gallbladder drainage for acute cholecystitis","volume":"15","author":"S Irani","year":"2017","journal-title":"Clin Gastroenterol Hepatol"},{"key":"ref7","first-page":"130","article-title":"Endoscopic ultrasound-guided gallbladder drainage reduces adverse events compared with percutaneous cholecystostomy in patients who are unfit for cholecystectomy","volume":"49","author":"A Y Teoh","year":"2017","journal-title":"Endoscopy"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1016\/j.gie.2016.07.067","article-title":"Percutaneous transhepatic versus EUS-guided gallbladder drainage for malignant cystic duct obstruction","volume":"85","author":"J H Choi","year":"2017","journal-title":"Gastrointest Endosc"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1053\/j.gastro.2011.12.051","article-title":"Endoscopic ultrasound-guided transmural and percutaneous transhepatic gallbladder drainage are comparable for acute cholecystitis","volume":"142","author":"J W Jang","year":"2012","journal-title":"Gastroenterology"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"3567","DOI":"10.1007\/s00464-019-07026-z","article-title":"Cost effectiveness of endoscopic gallbladder drainage to treat acute cholecystitis in poor surgical candidates","volume":"33","author":"J E Corral","year":"2019","journal-title":"Surg Endosc"}],"container-title":["Endoscopy International 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