{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,7]],"date-time":"2025-08-07T21:01:08Z","timestamp":1754600468951},"reference-count":31,"publisher":"Georg Thieme Verlag KG","issue":"08","license":[{"start":{"date-parts":[[2022,8,10]],"date-time":"2022-08-10T00:00:00Z","timestamp":1660089600000},"content-version":"vor","delay-in-days":9,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Geburtshilfe Frauenheilkd"],"published-print":{"date-parts":[[2022,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n          Introduction Preterm birth is defined as a live birth before 37\u00a0weeks of gestation and is associated with increased neonatal morbidity and mortality. The aim of this study is to\n\t\t\t\t\tcompare the efficacy of hexoprenaline and atosiban for short- and long-term tocolysis and their effects on neonatal and maternal outcomes.<\/jats:p><jats:p>\n          Methods This retrospective cohort study included women with threatened preterm labor between 24\u2009+\u20090 and 34\u2009+\u20090 weeks of gestation without premature rupture of membranes. The\n\t\t\t\t\ttocolytic efficacy of hexoprenaline and atosiban was compared in women receiving one of the two medications for short- and long-term tocolysis. Continuous variables were compared using\n\t\t\t\t\tt-test or Mann\u2013Whitney U test, as appropriate. Comparison of categorical variables between the two groups was done with \u03c72 test after Pearson\u02bcs and Fisher\u02bcs exact test.<\/jats:p><jats:p>\n          Results 761 women were enrolled in this study; 387 women received atosiban and 374 women received hexoprenaline as their primary tocolytic agent. Atosiban showed a higher efficacy as\n\t\t\t\t\ta primary tocolytic agent (p\u2009=\u20090.000) within 48\u00a0hours. As regards long-term tocolysis, there were no differences between the treatment groups (p\u2009=\u20090.466). Maternal side effects such as\n\t\t\t\t\ttachycardia (p\u2009=\u20090.018) or palpitations (p\u2009=\u20090.000) occurred more frequently after the administration of hexoprenaline, while there were no differences between the two drugs administered\n\t\t\t\t\twith regard to any other maternal or neonatal outcome parameter.<\/jats:p><jats:p>\n          Conclusion Our retrospective study shows a significantly higher efficacy of atosiban in the first 48 hours, especially when administered at an early gestational age. There were no\n\t\t\t\t\tsignificant differences in terms of neonatal outcome but significantly more maternal adverse effects during the administration of hexoprenaline.<\/jats:p>","DOI":"10.1055\/a-1823-0176","type":"journal-article","created":{"date-parts":[[2022,8,10]],"date-time":"2022-08-10T22:35:18Z","timestamp":1660170918000},"page":"852-858","source":"Crossref","is-referenced-by-count":1,"title":["Hexoprenaline Compared with Atosiban as Tocolytic Treatment for Preterm Labor"],"prefix":"10.1055","volume":"82","author":[{"given":"Ebba","family":"Kirchhoff","sequence":"additional","affiliation":[{"name":"Universit\u00e4tsklinik f\u00fcr Frauenheilkunde und Geburtshilfe der Med. Universit\u00e4t Graz, Graz, Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Verena","family":"Schneider","sequence":"additional","affiliation":[{"name":"Universit\u00e4tsklinik f\u00fcr Frauenheilkunde und Geburtshilfe der Med. Universit\u00e4t Graz, Graz, Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gerhard","family":"Pichler","sequence":"additional","affiliation":[{"name":"2 Klinische Abteilung f\u00fcr Neonatologie der Med. Universit\u00e4t Graz, Graz, Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philipp","family":"Reif","sequence":"additional","affiliation":[{"name":"Universit\u00e4tsklinik f\u00fcr Frauenheilkunde und Geburtshilfe der Med. Universit\u00e4t Graz, Graz, Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Josef","family":"Haas","sequence":"additional","affiliation":[{"name":"Universit\u00e4tsklinik f\u00fcr Frauenheilkunde und Geburtshilfe der Med. Universit\u00e4t Graz, Graz, Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maike","family":"Joksch","sequence":"additional","affiliation":[{"name":"Universit\u00e4tsklinik f\u00fcr Frauenheilkunde und Geburtshilfe der Med. Universit\u00e4t Graz, Graz, Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Corinna","family":"Mager","sequence":"additional","affiliation":[{"name":"Universit\u00e4tsklinik f\u00fcr Frauenheilkunde und Geburtshilfe der Med. Universit\u00e4t Graz, Graz, Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian","family":"Schmied","sequence":"additional","affiliation":[{"name":"Universit\u00e4tsklinik f\u00fcr Frauenheilkunde und Geburtshilfe der Med. Universit\u00e4t Graz, Graz, Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wolfgang","family":"Sch\u00f6ll","sequence":"additional","affiliation":[{"name":"Universit\u00e4tsklinik f\u00fcr Frauenheilkunde und Geburtshilfe der Med. Universit\u00e4t Graz, Graz, Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elisabeth","family":"Pichler-Stachl","sequence":"additional","affiliation":[{"name":"Universit\u00e4tsklinik f\u00fcr Frauenheilkunde und Geburtshilfe der Med. Universit\u00e4t Graz, Graz, Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniela","family":"Gold","sequence":"additional","affiliation":[{"name":"Universit\u00e4tsklinik f\u00fcr Frauenheilkunde und Geburtshilfe der Med. 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