{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T15:20:00Z","timestamp":1784647200605,"version":"3.55.0"},"reference-count":103,"publisher":"Georg Thieme Verlag KG","issue":"08","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Horm Metab Res"],"published-print":{"date-parts":[[2022,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The use of standard procedures for the diagnosis of osteoporosis and assessment\n                    of fracture risk significantly decreased during the COVID-19 pandemic, while the\n                    incidence of fragility fractures was mostly unaltered. Both COVID-19 per se and\n                    its treatments are associated with a negative impact on bone health. Preclinical\n                    models show that mice infected with SARS-CoV2 even without symptoms display loss\n                    of trabecular bone mass two weeks post infection, due to increased numbers of\n                    osteoclasts. Osteoporosis medications do not aggravate the clinical course of\n                    COVID-19, while preclinical data suggests possible beneficial effects of some\n                    therapies. While vitamin D deficiency is clearly associated with a worse\n                    clinical course of COVID-19, evidence of improved patient outcome with vitamin D\n                    supplementation is lacking. Osteoporosis treatment should not be generally\n                    discontinued, and recommendations for substituting therapies are available.\n                    Osteoporosis therapies do not interfere with the efficacy or side-effect\n                    profiles of COVID-19 vaccines and should not be stopped or indefinitely delayed\n                    because of vaccination.<\/jats:p>","DOI":"10.1055\/a-1825-9641","type":"journal-article","created":{"date-parts":[[2022,4,14]],"date-time":"2022-04-14T04:16:46Z","timestamp":1649909806000},"page":"540-548","source":"Crossref","is-referenced-by-count":8,"title":["The Impact of COVID-19 in Bone Metabolism: Basic and Clinical\n                    Aspects"],"prefix":"10.1055","volume":"54","author":[{"given":"Elena","family":"Tsourdi","sequence":"additional","affiliation":[{"name":"Department of Medicine III, University Clinic Dresden Medical Center,\n                    Dresden, Germany"},{"name":"Center for Healthy Aging, University Clinic Dresden Medical Center,\n                    Dresden, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lorenz C.","family":"Hofbauer","sequence":"additional","affiliation":[{"name":"Department of Medicine III, University Clinic Dresden Medical Center,\n                    Dresden, Germany"},{"name":"Center for Healthy Aging, University Clinic Dresden Medical Center,\n                    Dresden, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martina","family":"Rauner","sequence":"additional","affiliation":[{"name":"Department of Medicine III, University Clinic Dresden Medical Center,\n                    Dresden, Germany"},{"name":"Center for Healthy Aging, University Clinic Dresden Medical Center,\n                    Dresden, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2022,6,20]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1038\/s41579-020-00459-7","article-title":"Characteristics of SARS-CoV-2 and COVID-19","volume":"19","author":"B Hu","year":"2021","journal-title":"Nat Rev Microbiol"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"1197","DOI":"10.2106\/JBJS.20.00847","article-title":"Musculoskeletal consequences of COVID-19","volume":"102","author":"N P Disser","year":"2020","journal-title":"J Bone Joint Surg Am"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1038\/s41586-020-2179-y","article-title":"Structural basis of receptor recognition by SARS-CoV-2","volume":"581","author":"J Shang","year":"2020","journal-title":"Nature"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1038\/s41586-020-2180-5","article-title":"Structure of the 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