{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T21:49:26Z","timestamp":1773092966779,"version":"3.50.1"},"reference-count":145,"publisher":"Georg Thieme Verlag KG","issue":"02","license":[{"start":{"date-parts":[[2022,4,14]],"date-time":"2022-04-14T00:00:00Z","timestamp":1649894400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100008590","name":"Dr. Ralph and Marian Falk Medical Research Trust","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100008590","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"crossref","award":["R21 AI148986"],"award-info":[{"award-number":["R21 AI148986"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["SynOpen"],"published-print":{"date-parts":[[2022,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The synthesis of aromatic heterocycles has attracted substantial attention due to the abundance of these heterocycles in drug molecules, natural products, and other compounds of biological interest. Accordingly, there is a demand for straightforward synthetic protocols toward such compounds using readily available starting materials. In the past decade, there have been substantial developments in heterocycle synthesis, especially in metal-catalyzed and iodine-assisted approaches. This graphical review focuses on notable reactions from the past decade using aryl and heteroaryl methyl ketones as starting materials, including representative reaction mechanisms.<\/jats:p>","DOI":"10.1055\/a-1826-2852","type":"journal-article","created":{"date-parts":[[2022,4,15]],"date-time":"2022-04-15T00:54:46Z","timestamp":1649984086000},"page":"110-131","source":"Crossref","is-referenced-by-count":8,"title":["Aryl Methyl Ketones: Versatile Synthons in the Synthesis of Heterocyclic Compounds"],"prefix":"10.1055","volume":"06","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4852-0596","authenticated-orcid":false,"given":"Shabber","family":"Mohammed","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark J.","family":"Mitton-Fry","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6726-2625","authenticated-orcid":false,"given":"Jason S.","family":"West","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2022,6,8]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"3493","DOI":"10.3390\/molecules25153493","volume":"25","author":"M J Buskes","year":"2020","journal-title":"Molecules"},{"key":"ref2","first-page":"1","volume-title":"In Advances in Heterocyclic Chemistry, Vol. 121","author":"T Y Zhang","year":"2017"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"3734","DOI":"10.1039\/D0QO00698J","volume":"7","author":"I Khan","year":"2020","journal-title":"Org. 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