{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T08:33:51Z","timestamp":1740126831399,"version":"3.37.3"},"reference-count":43,"publisher":"Georg Thieme Verlag KG","issue":"S 01","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am J Perinatol"],"published-print":{"date-parts":[[2024,5]]},"abstract":"<jats:p>\n            Objective\u2003Progesterone administration has been associated with improved neurological outcomes following traumatic brain injury in adults. However, studies examining the effect of progesterone on the risk of neonatal intraventricular hemorrhage (IVH) are inconsistent. We sought to determine if maternal administration of intramuscular 17-\u03b1-hydroxyprogesterone caproate (17-OHPC) is associated with decreased rates of IVH in infants born before 32-weeks gestation.<\/jats:p><jats:p>\n            Study Design\u2003This is a retrospective study of liveborn singleton deliveries between 20- and 32-weeks gestation at two large academic medical centers from January 1, 2012 to August 30, 2020. Data were extracted from hospital electronic medical record data warehouses using standardized definitions and billing and diagnosis codes. We evaluated receipt of 17-OHPC in the antepartum period and diagnosis of IVH (grade I-IV, per Volpe classification) during the neonatal delivery hospitalization encounter. Bivariate and multivariate analyses were performed to examine the association between 17-OHPC and neonatal IVH adjusting for potential confounders. Odds ratio (ORs) and 95% confidence intervals (CIs) were presented.<\/jats:p><jats:p>\n            Results\u2003Among 749 neonates born between 20- and 32-week gestation, 140 (18.7%) of their mothers had received antenatal 17-OHPC and 148 (19.8%) were diagnosed with IVH after birth. No significant association was observed between maternal 17-OHPC and neonatal IVH in unadjusted (OR 1.14, 95% CI 0.72\u20131.78) or adjusted analyses (adjusted odds ratio 1.14, 95% CI 0.71\u20131.84). Independent of exposure to 17-OHPC, as expected, infants born &lt;28-weeks gestation or those with very low birthweight (&lt;1,500\u2009g) were at an increased risk of IVH (OR 2.32, 95% CI 1.55\u20133.48 and OR 2.19, 95% CI 1.09\u20134.38, respectively).<\/jats:p><jats:p>\n            Conclusion\u2003Antenatal maternal 17-OHPC administration was not associated with the risk of neonatal IVH. Further research may be warranted to determine whether timing, route of delivery, and duration of progesterone therapy impact rates of neonatal IVH.<\/jats:p><jats:p>\n            Key Points\n          <\/jats:p>","DOI":"10.1055\/a-1827-6712","type":"journal-article","created":{"date-parts":[[2022,4,18]],"date-time":"2022-04-18T23:16:01Z","timestamp":1650323761000},"page":"e46-e52","source":"Crossref","is-referenced-by-count":0,"special_numbering":"S","title":["Does Antenatal Progesterone Administration Modify the Risk of Neonatal Intraventricular Hemorrhage?"],"prefix":"10.1055","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2875-1936","authenticated-orcid":false,"given":"Daisy","family":"Leon-Martinez","sequence":"additional","affiliation":[{"name":"Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, New Haven, Connecticut"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tracy C.","family":"Bank","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Christiana Care Health System, Newark, Delaware"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lisbet S.","family":"Lundsberg","sequence":"additional","affiliation":[{"name":"Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, New Haven, Connecticut"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jennifer","family":"Culhane","sequence":"additional","affiliation":[{"name":"Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, New Haven, Connecticut"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michelle","family":"Silasi","sequence":"additional","affiliation":[{"name":"Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, New Haven, Connecticut"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Moeun","family":"Son","sequence":"additional","affiliation":[{"name":"Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, New Haven, Connecticut"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Caitlin","family":"Partridge","sequence":"additional","affiliation":[{"name":"Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, New Haven, Connecticut"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Uma M.","family":"Reddy","sequence":"additional","affiliation":[{"name":"Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, New Haven, Connecticut"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2927-8693","authenticated-orcid":false,"given":"Matthew K.","family":"Hoffman","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Christiana Care Health System, Newark, Delaware"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Audrey A.","family":"Merriam","sequence":"additional","affiliation":[{"name":"Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, New Haven, Connecticut"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2022,6,10]]},"reference":[{"volume-title":"Volpe's Neurology of the Newborn","year":"2018","author":"J Volpe","key":"ref1"},{"issue":"03","key":"ref2","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/S1071-9091(98)80030-2","article-title":"Brain injury in the premature infant: overview of clinical aspects, neuropathology, and pathogenesis","volume":"5","author":"J J Volpe","year":"1998","journal-title":"Semin Pediatr 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Yousuf","year":"2016","journal-title":"Horm Behav"},{"issue":"06","key":"ref31","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1211\/jpp.60.6.0008","article-title":"Neuroprotective effect of progesterone on acute phase changes induced by partial global cerebral ischaemia in mice","volume":"60","author":"R Aggarwal","year":"2008","journal-title":"J Pharm Pharmacol"},{"issue":"04","key":"ref32","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1007\/s10571-018-0627-0","article-title":"Steroids in stroke with special reference to progesterone","volume":"39","author":"R Guennoun","year":"2019","journal-title":"Cell Mol Neurobiol"},{"issue":"06","key":"ref33","doi-asserted-by":"crossref","first-page":"930","DOI":"10.1016\/j.neuropharm.2010.01.002","article-title":"Treatment with progesterone after focal cerebral ischemia suppresses proliferation of progenitor cells but enhances survival of newborn neurons in adult male mice","volume":"58","author":"Z Zhang","year":"2010","journal-title":"Neuropharmacology"},{"issue":"01","key":"ref34","doi-asserted-by":"crossref","first-page":"16179","DOI":"10.1038\/s41598-020-73227-5","article-title":"Drugs with anti-inflammatory effects to improve outcome of traumatic brain injury: a meta-analysis","volume":"10","author":"M Begemann","year":"2020","journal-title":"Sci Rep"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"265","DOI":"10.2147\/DDDT.S192633","article-title":"Effect of progesterone administration on the prognosis of patients with severe traumatic brain injury: a meta-analysis of randomized clinical trials","volume":"13","author":"Z Y Pan","year":"2019","journal-title":"Drug Des Devel Ther"},{"issue":"02","key":"ref36","doi-asserted-by":"crossref","first-page":"R61","DOI":"10.1186\/cc6887","article-title":"Improved outcomes from the administration of progesterone for patients with acute severe traumatic brain injury: a randomized controlled trial","volume":"12","author":"G 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01","published-online":{"date-parts":[[2024,5,13]]},"published-print":{"date-parts":[[2024,5]]}},"URL":"https:\/\/doi.org\/10.1055\/a-1827-6712","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["0735-1631","1098-8785"],"issn-type":[{"type":"print","value":"0735-1631"},{"type":"electronic","value":"1098-8785"}],"subject":[],"published-other":{"date-parts":[[2022,4,18]]},"published":{"date-parts":[[2022,4,18]]}}}