{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T01:14:46Z","timestamp":1771463686189,"version":"3.50.1"},"reference-count":30,"publisher":"Georg Thieme Verlag KG","issue":"S 01","funder":[{"name":"Beltzman Grant","award":["E2457556"],"award-info":[{"award-number":["E2457556"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am J Perinatol"],"published-print":{"date-parts":[[2024,5]]},"abstract":"<jats:p>\n            Objective\u2003The objective was to evaluate the utility of brain natriuretic peptide (BNP), troponin, galectin-3 (Gal-3), and microRNA (miRNA)-126a-5p as screening biomarkers for persistent pulmonary hypertension of the newborn (PPHN) by comparing expression in serum of infants with hypoxic-ischemic injury that develop PPHN to those that do not.<\/jats:p><jats:p>\n            Study Design\u2003This was a prospective, observational pilot study including neonates with hypoxic-ischemic injury undergoing therapeutic hypothermia (TH) at two regional perinatal medical centers. PPHN in this population was diagnosed clinically and confirmed by echocardiogram. Serial measurements of biomarkers were performed from 6 to 96\u2009hours post-TH initiation in 40 patients.<\/jats:p><jats:p>\n            Results\u2003Of 40 infants in the study, 10 (25%) developed PPHN and 30 (75%) did not. Baseline demographics and hemodynamics were similar between the groups. Patients with PPHN had a significantly higher need for vasopressors compared with patients without PPHN (70 vs. 27%, p\u2009=\u20090.007). Mean serum BNP and troponin levels were significantly higher in the PPHN group peaking at 12 to 24\u2009hours and decreasing following PPHN treatment initiation. miRNA-126a-5p expression was increased in patients with PPHN compared with patients without, with statistical significance detected at 12\u2009hours (p\u2009=\u20090.005) and 96\u2009hours (p\u2009=\u20090.01). Mean circulating Gal-3 levels were not statistically different between the two groups; however, Gal-3 was elevated in all patients with hypoxic-ischemic injury on TH compared with healthy infants from prior studies.<\/jats:p><jats:p>\n            Conclusion\u2003BNP and troponin are readily available, low-cost biomarkers that showed significant serial elevations in the PPHN group of the study and, thus, may have value in screening for PPHN in the setting of hypoxic-ischemic encephalopathy (HIE). Gal-3 was elevated in all patients with HIE and may be a useful biomarker of hypoxic injury in infants being evaluated for TH. Elevations in miRNA-126a-5p were not consistently seen in this study. Larger studies are required to establish an association between PPHN and these biomarkers in patients with and without HIE.<\/jats:p><jats:p>\n            Key Points\n          <\/jats:p>","DOI":"10.1055\/a-1827-7518","type":"journal-article","created":{"date-parts":[[2022,4,18]],"date-time":"2022-04-18T23:16:01Z","timestamp":1650323761000},"page":"e60-e68","source":"Crossref","is-referenced-by-count":3,"special_numbering":"S","title":["Pilot Study Investigating Brain Natriuretic Peptide, Troponin, Galectin-3, and miRNA-126a-5p as Biomarkers of Persistent Pulmonary Hypertension in Neonates with Hypoxic-Ischemic Injury Receiving Therapeutic Hypothermia"],"prefix":"10.1055","volume":"41","author":[{"given":"Eni","family":"Jano","sequence":"additional","affiliation":[{"name":"Division of Neonatology, Department of Pediatrics, NYU Grossman School of Medicine, New York, New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michelle J.","family":"Vaz","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, NYU Grossman School of Medicine, Bellevue Hospital Center Neonatal Intensive Care Unit, New York, New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pradeep N.","family":"Mally","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, NYU Grossman School of Medicine, Bellevue Hospital Center Neonatal Intensive Care Unit, New York, New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elena V.","family":"Wachtel","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, NYU Grossman School of Medicine, Bellevue Hospital Center Neonatal Intensive Care Unit, New York, New York"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2022,6,6]]},"reference":[{"issue":"20","key":"ref1","doi-asserted-by":"crossref","first-page":"2551","DOI":"10.1016\/j.jacc.2017.03.575","article-title":"Pulmonary hypertension in infants, children and young adults","volume":"69","author":"G Hansmann","year":"2017","journal-title":"J Am Coll Cardiol"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.jpeds.2017.12.055","article-title":"Pulmonary hypertension associated with hypoxic ischemic encephalopathy-antecedent characteristics and comorbidities","volume":"196","author":"S Lakshminrusimha","year":"2018","journal-title":"J Pediatr"},{"issue":"S 02","key":"ref3","doi-asserted-by":"crossref","first-page":"ii86","DOI":"10.1136\/heartjnl-2015-309132","article-title":"Executive summary. 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