{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T02:59:34Z","timestamp":1792205974864,"version":"4.4.0"},"reference-count":43,"publisher":"Georg Thieme Verlag KG","issue":"15","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am J Perinatol"],"published-print":{"date-parts":[[2023,11]]},"abstract":"<jats:p>This review was conducted to evaluate the efficacy of light-emitting diode (LED) phototherapy as compared with the conventional phototherapy in neonates with unconjugated hyperbilirubinemia and their adverse effects. We searched the following databases right from their inception till April, 2021: MEDLINE, EMBASE, Cochrane Library, and LILACS. Randomized clinical trials (RCTs) comparing the LED phototherapy with other light sources, which enrolled newborns (term and preterm) with unconjugated hyperbilirubinemia were included. We included 21 articles in this review. The treatment with the LED light therapy had a lower failure rate as compared with the non-LED one (RR = 0.60, 95% CI: 0.39\u20130.94). The mean duration of phototherapy was significantly shorter in the group with the LED light source as compared with the one with the non-LED light source (mean difference [hours]: \u22128.07, 95% CI: \u22128.45 to \u22127.68), regardless of the type of non-LED units. However, the rate of bilirubin showed a comparable decline (mean difference [mg\/dL\/h]: 0.01, 95% CI: \u22120.00, 0.03) in both the light sources, irrespective of irradiance or distance. No studies reported primary outcomes related to the neurotoxicity effects of hyperbilirubinemia in neonates. The LED light devices caused a significantly higher risk of hypothermia. Neonates were at a lower risk of developing hyperthermia and skin rash with the LED light therapy. Our findings provide support for the use of LED light source phototherapy due to its better clinical efficacy, which is evidenced by its shorter duration and lower rate of treatment failure, as compared with the non-LED light sources.<\/jats:p><jats:p>\n            Key Points\n          <\/jats:p>","DOI":"10.1055\/a-1827-7607","type":"journal-article","created":{"date-parts":[[2022,4,18]],"date-time":"2022-04-18T23:16:01Z","timestamp":1650323761000},"page":"1618-1628","source":"Crossref","is-referenced-by-count":12,"title":["Light-Emitting Diode (LED) Phototherapy versus Non-LED Phototherapy Devices for Hyperbilirubinemia in Neonates: A Systematic Review and Meta-analysis"],"prefix":"10.1055","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0654-7408","authenticated-orcid":false,"given":"Rommy H.","family":"Novoa","sequence":"additional","affiliation":[{"name":"High-Risk Pregnancy Unit, Obstetrics and Perinatology Department, Instituto Nacional Materno Perinatal, Lima, Peru"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen","family":"Huaman","sequence":"additional","affiliation":[{"name":"Unidad de An\u00e1lisis y Generaci\u00f3n de Evidencias en Salud P\u00fablica (UNAGESP), Instituto Nacional de Salud, Ministerio de Salud Lima, Lima, Peru"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia","family":"Caballero","sequence":"additional","affiliation":[{"name":"Unidad de An\u00e1lisis y Generaci\u00f3n de Evidencias en Salud P\u00fablica (UNAGESP), Instituto Nacional de Salud, Ministerio de Salud Lima, Lima, Peru"},{"name":"Academic Department of Medical Microbiology, School of Medicine \u201cSan Fernando,\u201d Universidad Nacional Mayor de San Marcos, Lima, Peru"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2022,6,7]]},"reference":[{"issue":"08","key":"ref1","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1016\/S2352-4642(18)30139-1","article-title":"Neonatal hyperbilirubinaemia: a global perspective","volume":"2","author":"B O Olusanya","year":"2018","journal-title":"Lancet Child Adolesc Health"},{"issue":"03","key":"ref2","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1016\/j.jpeds.2012.08.022","article-title":"Predischarge screening for severe neonatal hyperbilirubinemia identifies infants who need phototherapy","volume":"162","author":"V K Bhutani","year":"2013","journal-title":"J Pediatr"},{"issue":"09","key":"ref3","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1038\/sj.jp.7211789","article-title":"Randomized controlled trial of light-emitting diode phototherapy","volume":"27","author":"M J Maisels","year":"2007","journal-title":"J Perinatol"},{"issue":"04","key":"ref4","doi-asserted-by":"crossref","first-page":"e47","DOI":"10.1542\/peds.110.4.e47","article-title":"Imbalance between production and conjugation of bilirubin: a fundamental concept in the mechanism of neonatal jaundice","volume":"110","author":"M Kaplan","year":"2002","journal-title":"Pediatrics"},{"issue":"21","key":"ref5","doi-asserted-by":"crossref","first-page":"2021","DOI":"10.1056\/NEJMra1308124","article-title":"Bilirubin-induced neurologic damage\u2014mechanisms and management approaches","volume":"369","author":"J F Watchko","year":"2013","journal-title":"N Engl J Med"},{"key":"ref6","first-page":"Pii.0319","article-title":"Neonatal jaundice","volume":"2011","author":"P Woodgate","year":"2011","journal-title":"BMJ Clin Evid"},{"issue":"01","key":"ref7","doi-asserted-by":"crossref","first-page":"e130","DOI":"10.1542\/peds.114.1.e130","article-title":"An evidence-based review of important issues concerning neonatal hyperbilirubinemia","volume":"114","author":"S Ip","year":"2004","journal-title":"Pediatrics"},{"issue":"02","key":"ref8","doi-asserted-by":"crossref","first-page":"e0117229","DOI":"10.1371\/journal.pone.0117229","article-title":"Risk factors for severe neonatal hyperbilirubinemia in low and middle-income countries: a systematic review and meta-analysis","volume":"10","author":"B O Olusanya","year":"2015","journal-title":"PLoS One"},{"issue":"08","key":"ref9","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1542\/pir.32.8.341","article-title":"Hyperbilirubinemia in the newborn","volume":"32","author":"B J Lauer","year":"2011","journal-title":"Pediatr Rev"},{"issue":"01","key":"ref10","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1542\/peds.114.1.297","article-title":"Management of hyperbilirubinemia in the newborn infant 35 or more weeks of gestation","volume":"114","author":"American Academy of Pediatrics Subcommittee on Hyperbilirubinemia","year":"2004","journal-title":"Pediatrics"},{"issue":"02","key":"ref11","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1016\/S0095-5108(18)30579-7","article-title":"Blue light, green light, white light, more light: treatment of neonatal jaundice","volume":"17","author":"J F Ennever","year":"1990","journal-title":"Clin Perinatol"},{"issue":"01","key":"ref12","first-page":"CD002060","article-title":"Fibreoptic phototherapy for neonatal jaundice","volume":"1","author":"J F Mills","year":"2001","journal-title":"Cochrane Database Syst Rev"},{"issue":"01","key":"ref13","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/S0022-3476(89)80620-1","article-title":"Efficacy of fluorescent daylight, blue, and green lamps in the management of nonhemolytic hyperbilirubinemia","volume":"114","author":"K L Tan","year":"1989","journal-title":"J Pediatr"},{"issue":"03","key":"ref14","first-page":"176","article-title":"Update on phototherapy in jaundiced neonates","volume":"13","author":"F Ebbesen","year":"2017","journal-title":"Curr Pediatr Rev"},{"issue":"02","key":"ref15","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1038\/sj.jp.7210862","article-title":"A prospective randomized controlled study of phototherapy using blue and blue-green light-emitting devices, and conventional halogen-quartz phototherapy","volume":"23","author":"D S Seidman","year":"2003","journal-title":"J Perinatol"},{"issue":"12","key":"ref16","first-page":"CD007969","article-title":"Light-emitting diode phototherapy for unconjugated hyperbilirubinaemia in neonates","volume":"12","author":"P Kumar","year":"2011","journal-title":"Cochrane Database Syst Rev"},{"issue":"07","key":"ref17","doi-asserted-by":"crossref","first-page":"e1000097","DOI":"10.1371\/journal.pmed.1000097","article-title":"Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement","volume":"6","author":"D Moher","year":"2009","journal-title":"PLoS Med"},{"key":"ref18","first-page":"746","article-title":"BIND\u2014a clinical score for bilirubin-induced neurologic dysfunction in newborns","volume":"199","author":"L HBA Johnson","year":"1999","journal-title":"Pediatrics"},{"issue":"01","key":"ref19","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1038\/sj.jp.7211157","article-title":"Definition of the clinical spectrum of kernicterus and bilirubin-induced neurologic dysfunction (BIND)","volume":"25","author":"S M Shapiro","year":"2005","journal-title":"J Perinatol"},{"issue":"432","key":"ref20","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1111\/j.1651-2227.1999.tb01165.x","article-title":"Automated auditory brainstem response in neonatal hearing screening","volume":"88","author":"H L van Straaten","year":"1999","journal-title":"Acta Paediatr Suppl"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"d5928","DOI":"10.1136\/bmj.d5928","article-title":"The Cochrane Collaboration's tool for assessing risk of bias in randomised trials","volume":"343","author":"J P Higgins","year":"2011","journal-title":"BMJ"},{"key":"ref22","volume-title":"GRADE Handbook for Grading Quality of Evidence and Strength of Recommendations","author":"Schunemann HBrozek J.","year":"2015"},{"issue":"06","key":"ref23","first-page":"771","article-title":"A new blue light-emitting phototherapy device: a prospective randomized controlled study","volume":"136","author":"D S Seidman","year":"2000","journal-title":"J Pediatr"},{"issue":"03","key":"ref24","doi-asserted-by":"crossref","first-page":"253","DOI":"10.2223\/JPED.1637","article-title":"Efficacy of new microprocessed phototherapy system with five high intensity light emitting diodes (Super LED)","volume":"83","author":"B M Martins","year":"2007","journal-title":"J Pediatr (Rio J)"},{"issue":"01","key":"ref25","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1007\/s00431-007-0421-3","article-title":"Transepidermal water loss and cerebral hemodynamics in preterm infants: conventional versus LED phototherapy","volume":"167","author":"G Bertini","year":"2008","journal-title":"Eur J Pediatr"},{"issue":"02","key":"ref26","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1007\/s13312-010-0020-7","article-title":"Light emitting diodes versus compact fluorescent tubes for phototherapy in neonatal jaundice: a multicenter randomized controlled trial","volume":"47","author":"P Kumar","year":"2010","journal-title":"Indian Pediatr"},{"issue":"05","key":"ref27","doi-asserted-by":"crossref","first-page":"E335","DOI":"10.25011\/cim.v33i5.14359","article-title":"Comparison of total oxidant\/antioxidant status in unconjugated hyperbilirubinemia of newborn before and after conventional and LED phototherapy: a prospective randomized controlled trial","volume":"33","author":"G Demirel","year":"2010","journal-title":"Clin Invest Med"},{"issue":"02","key":"ref28","first-page":"57","article-title":"Comparaci\u00f3n de la eficacia de la fototerapia convencional con tubos de luz azul vs. LEDs","volume":"31","author":"J Meritano","year":"2012","journal-title":"Rev Hosp Matern Infant Ramon Sarda"},{"issue":"07","key":"ref29","first-page":"884","article-title":"Effectiveness of conventional phototherapy versus Super light-emitting diodes phototherapy in neonatal hyperbilirubinemia","volume":"95","author":"S Ngerncham","year":"2012","journal-title":"J Med Assoc Thai"},{"issue":"03","key":"ref30","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1093\/tropej\/fmr063","article-title":"Prospective randomized controlled study comparing low-cost LED and conventional phototherapy for treatment of neonatal hyperbilirubinemia","volume":"58","author":"J Viau Colindres","year":"2012","journal-title":"J Trop Pediatr"},{"issue":"12","key":"ref31","first-page":"1536","article-title":"The efficacy of the in-house light-emitting diode phototherapy equipment compare to conventional phototherapy equipment on the treatment of neonatal hyperbilirubinemia","volume":"96","author":"R Ek-isariyaphorn","year":"2013","journal-title":"J Med Assoc Thai"},{"issue":"14","key":"ref32","doi-asserted-by":"crossref","first-page":"1725","DOI":"10.3109\/14767058.2014.966678","article-title":"LED versus daylight phototherapy at low irradiance in newborns \u226535 weeks of gestation: randomized controlled trial","volume":"28","author":"D CB Brand\u00e3o","year":"2015","journal-title":"J Matern Fetal Neonatal Med"},{"issue":"08","key":"ref33","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1055\/s-0034-1396685","article-title":"Broad-spectrum light versus blue light for phototherapy in neonatal hyperbilirubinemia: a randomized controlled trial","volume":"32","author":"S Pratesi","year":"2015","journal-title":"Am J Perinatol"},{"issue":"02","key":"ref34","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1179\/2046905515Y.0000000006","article-title":"High-intensity light-emitting diode vs fluorescent tubes for intensive 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trial","volume":"69","author":"A Tufail","year":"2019","journal-title":"J Pak Med Assoc"},{"issue":"01","key":"ref41","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1186\/s12887-020-02458-2","article-title":"Effectiveness of FIBEROPTIC phototherapy compared to conventional phototherapy in treating HYPERBILIRUBINEMIA amongst term neonates: a randomized controlled trial","volume":"21","author":"H N Joel","year":"2021","journal-title":"BMC Pediatr"},{"issue":"05","key":"ref42","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1111\/j.1651-2227.2011.02561.x","article-title":"Efficacy of light-emitting diode versus other light sources for treatment of neonatal hyperbilirubinemia: a systematic review and meta-analysis","volume":"101","author":"A Tridente","year":"2012","journal-title":"Acta Paediatr"},{"issue":"04","key":"ref43","doi-asserted-by":"crossref","first-page":"e1046","DOI":"10.1542\/peds.2011-1494","article-title":"Phototherapy to prevent severe neonatal 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