{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T08:33:51Z","timestamp":1740126831012,"version":"3.37.3"},"reference-count":17,"publisher":"Georg Thieme Verlag KG","issue":"S 01","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am J Perinatol"],"published-print":{"date-parts":[[2024,5]]},"abstract":"<jats:p>\n            Objective\u2003Prostaglandin inhibitors are used for the treatment of patent ductus arteriosus (PDA) and they often transiently decrease the urine output (UO) due to prostaglandin inhibition in the renal vasculature. We hypothesized that preterm infants whose renal vasculature shows greater sensitivity to prostaglandin inhibitors are likely to have ductal tissue with greater sensitivity to the same. Our objective was to determine whether the decrease in UO following treatment of PDA with a prostaglandin inhibitor is associated with a higher probability of PDA closure.<\/jats:p><jats:p>\n            Study Design\u2003In a prospective, proof-of-concept, cohort study, we enrolled 40 preterm neonates with hemodynamically significant PDA (hsPDA), being treated with a prostaglandin inhibitor. The key predictor, UO, was measured at baseline and daily until 72\u2009hours. We repeated echocardiography daily until PDA closure or the end of treatment. The key outcome was PDA closure. We compared \u201cPDA-closed\u201d (n\u2009=\u200928) and \u201cPDA-open\u201d (n\u2009=\u200912) groups for change in UO from baseline.<\/jats:p><jats:p>\n            Results\u2003The median (Q1, Q3) percent decrease in UO (figures rounded off to integers) was greater in the \u201cPDA-closed\u201d versus \u201cPDA-open\u201d group: from baseline to 0 to 24\u2009hours [\u221245% (\u221255%, +0.04%) vs. \u221215% (\u221228%, +49%)]; baseline to 24 to 48\u2009hours [\u221241% (\u221253%, +14%) vs. \u22123% (\u221225%, +62%), p\u2009=\u20090.03] and baseline to 48 to 72\u2009hours [\u221233% (\u221249%, +32%) vs. +21% (\u22127%, +98%), p\u2009=\u20090.02]. Decrease in UO preceded PDA closure. The \u201cPDA-closed\u201d group had significantly greater weight loss, despite a greater decrease in UO. A decrease in UO of 27 and 17% by 24 to 48\u2009hours and 48 to 72\u2009hours, respectively, best predicted PDA closure.<\/jats:p><jats:p>\n            Conclusion\u2003A decrease in UO after treating hsPDA with a prostaglandin inhibitor is associated with successful closure of PDA.<\/jats:p><jats:p>\n            Key Points\n          <\/jats:p>","DOI":"10.1055\/a-1827-7674","type":"journal-article","created":{"date-parts":[[2022,4,18]],"date-time":"2022-04-18T23:16:01Z","timestamp":1650323761000},"page":"e53-e59","source":"Crossref","is-referenced-by-count":0,"special_numbering":"S","title":["Relationship between Decrease in Urine Output following Treatment with Prostaglandin Inhibitors and PDA Closure"],"prefix":"10.1055","volume":"41","author":[{"given":"Malika","family":"Goel","sequence":"additional","affiliation":[{"name":"Division of Neonatology, Department of Pediatrics, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5595-8289","authenticated-orcid":false,"given":"Sourabh","family":"Dutta","sequence":"additional","affiliation":[{"name":"Division of Neonatology, Department of Pediatrics, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shiv Sajan","family":"Saini","sequence":"additional","affiliation":[{"name":"Division of Neonatology, Department of Pediatrics, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Venkataseshan","family":"Sundaram","sequence":"additional","affiliation":[{"name":"Division of Neonatology, Department of Pediatrics, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh, India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2022,5,31]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"147","DOI":"10.3389\/fped.2017.00147","article-title":"Echocardiographic evaluation of patent ductus arteriosus in preterm infants","volume":"5","author":"R Arlettaz","year":"2017","journal-title":"Front Pediatr"},{"issue":"S 01","key":"ref2","doi-asserted-by":"crossref","first-page":"S14","DOI":"10.1038\/sj.jp.7211465","article-title":"Patent ductus arteriosus: pathophysiology and management","volume":"26","author":"E R Hermes-DeSantis","year":"2006","journal-title":"J Perinatol"},{"issue":"12","key":"ref3","doi-asserted-by":"crossref","first-page":"1221","DOI":"10.1001\/jama.2018.1896","article-title":"Association of placebo, indomethacin, ibuprofen, and acetaminophen with closure of hemodynamically significant patent ductus arteriosus in preterm infants: a systematic review and meta-analysis","volume":"319","author":"S Mitra","year":"2018","journal-title":"JAMA"},{"issue":"02","key":"ref4","doi-asserted-by":"crossref","first-page":"106","DOI":"10.2174\/1574886309999141030142847","article-title":"Safety of therapeutics used in management of patent ductus arteriosus in preterm infants","volume":"10","author":"M Y Oncel","year":"2015","journal-title":"Curr Drug Saf"},{"issue":"11","key":"ref5","doi-asserted-by":"crossref","first-page":"e77888","DOI":"10.1371\/journal.pone.0077888","article-title":"Comparison of oral paracetamol versus ibuprofen in premature infants with patent ductus arteriosus: a randomized controlled trial","volume":"8","author":"D Dang","year":"2013","journal-title":"PLoS One"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.jpeds.2016.04.066","article-title":"Paracetamol accelerates closure of the ductus arteriosus after premature birth: a randomized trial","volume":"177","author":"P H\u00e4rkin","year":"2016","journal-title":"J Pediatr"},{"key":"ref7","first-page":"CD010061","article-title":"Paracetamol (acetaminophen) for patent ductus arteriosus in preterm or low birth weight infants","volume":"4","author":"A Ohlsson","year":"2018","journal-title":"Cochrane Database Syst Rev"},{"key":"ref8","first-page":"335","article-title":"Comparison of the efficacy of ibuprofen and indomethacin in the treatment of patent ductus arteriosus in prematurely born infants","volume":"9","author":"E Adamska","year":"2005","journal-title":"Med Wieku Rozwoj"},{"issue":"02","key":"ref9","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1007\/s00431-016-2830-7","article-title":"Comparative study of the efficacy and safety of paracetamol, ibuprofen, and indomethacin in closure of patent ductus arteriosus in preterm neonates","volume":"176","author":"A E El-Mashad","year":"2017","journal-title":"Eur J Pediatr"},{"issue":"09","key":"ref10","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1038\/jp.2015.33","article-title":"Predictors of successful closure of patent ductus arteriosus with indomethacin","volume":"35","author":"M F Ahamed","year":"2015","journal-title":"J Perinatol"},{"issue":"09","key":"ref11","first-page":"763","article-title":"Predictors of failed closure of patent ductus arteriosus with indomethacin","volume":"47","author":"N Y Boo","year":"2006","journal-title":"Singapore Med J"},{"issue":"06","key":"ref12","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1016\/j.jpeds.2007.05.007","article-title":"Risk factors for persistent ductus arteriosus patency during indomethacin treatment","volume":"151","author":"N Chorne","year":"2007","journal-title":"J Pediatr"},{"issue":"02","key":"ref13","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1067\/S0022-3476(03)00303-2","article-title":"Indomethacin responsiveness of patent ductus arteriosus and renal abnormalities in preterm infants treated with indomethacin","volume":"143","author":"K Itabashi","year":"2003","journal-title":"J Pediatr"},{"issue":"01","key":"ref14","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.jtcvs.2007.07.027","article-title":"The effect of ductal diameter on surgical and medical closure of patent ductus arteriosus in preterm neonates: size matters","volume":"135","author":"S Tschuppert","year":"2008","journal-title":"J Thorac Cardiovasc Surg"},{"issue":"07","key":"ref15","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1007\/s00431-016-2731-9","article-title":"Intravenous paracetamol for PDA closure in the preterm: a single-center experience","volume":"175","author":"E Valerio","year":"2016","journal-title":"Eur J Pediatr"},{"issue":"02","key":"ref16","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1007\/s12519-008-0017-7","article-title":"Factors affecting successful closure of hemodynamically significant patent ductus arteriosus with indomethacin in extremely low birth weight infants","volume":"4","author":"C Z Yang","year":"2008","journal-title":"World J Pediatr"},{"issue":"04","key":"ref17","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1111\/jpc.15266","article-title":"Association between changes in urine output and successful indomethacin treatment for patent ductus arteriosus in preterm neonates","volume":"57","author":"D Louis","year":"2021","journal-title":"J Paediatr Child Health"}],"container-title":["American Journal of 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