{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T08:33:34Z","timestamp":1740126814332,"version":"3.37.3"},"reference-count":31,"publisher":"Georg Thieme Verlag KG","issue":"05","funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["81903509"],"award-info":[{"award-number":["81903509"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Planta Med"],"published-print":{"date-parts":[[2023,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Eurya chinensis has been recorded as a folk medicine traditionally used for treatment of a variety of symptoms. However, the phytochemical and pharmacological investigations of this plant are still scarce. A novel phenolic glycoside named Euryachincoside (ECS) was isolated by chromatographic separation from E. chinensis, and its chemical structure was identified by analysis of HRMS and NMR data. Its anti-hepatic fibrosis effects were evaluated in both HSC-T6 (rat hepatic stellate cells) and carbon tetrachloride (CCl4)-induced mice with Silybin (SLB) as the positive control. In an in vitro study, ECS showed little cytotoxicity and inhibited transforming growth factor-beta (TGF-\u03b2)-induced Collagen I (Col1) along with alpha-smooth muscle actin (\u03b1-SMA) expressions in HSC-T6. An in vivo study suggested ECS significantly ameliorated hepatic injury, secretions of inflammatory cytokines, and collagen depositions. Moreover, ECS markedly mediated Smad2\/3, nuclear factor kappa B (NF-\u03baB) and nuclear factor erythroid 2-related factor 2 (Nrf2) signaling pathways both in vitro and vivo. These present findings confirmed that ECS is a novel phenolic glycoside from E. chinensis with promising curative effects on hepatic fibrosis, and its mechanisms may include decreasing extracellular matrix accumulation, reducing inflammation and attenuating free radicals via Smad2\/3, NF-\u03baB and Nrf2 signaling pathways, which may shed light on the exploration of more effective phenolic glycoside-based anti-fibrotic agents.<\/jats:p>","DOI":"10.1055\/a-1828-2671","type":"journal-article","created":{"date-parts":[[2022,4,19]],"date-time":"2022-04-19T23:47:30Z","timestamp":1650412050000},"page":"516-525","source":"Crossref","is-referenced-by-count":1,"title":["Euryachincoside, a Novel Phenolic Glycoside with Anti-Hepatic Fibrosis Activity from Eurya chinensis"],"prefix":"10.1055","volume":"89","author":[{"given":"Bai-Lin","family":"Li","sequence":"first","affiliation":[{"name":"School of Pharmaceutical Science, Guangzhou University of Chinese Medicine, Guangzhou, P.\u200aR. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hui-Jun","family":"Liang","sequence":"first","affiliation":[{"name":"School of Pharmaceutical Science, Guangzhou University of Chinese Medicine, Guangzhou, P.\u200aR. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qian-Ran","family":"Li","sequence":"additional","affiliation":[{"name":"School of Pharmaceutical Science, Guangzhou University of Chinese Medicine, Guangzhou, P.\u200aR. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qian","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Pharmaceutical Science, Guangzhou University of Chinese Medicine, Guangzhou, P.\u200aR. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhuo-Yi","family":"Ao","sequence":"additional","affiliation":[{"name":"School of Pharmaceutical Science, Guangzhou University of Chinese Medicine, Guangzhou, P.\u200aR. 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