{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T16:50:04Z","timestamp":1788195004664,"version":"build-2803163510"},"reference-count":80,"publisher":"Georg Thieme Verlag KG","issue":"09","license":[{"start":{"date-parts":[[2022,4,20]],"date-time":"2022-04-20T00:00:00Z","timestamp":1650412800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100012698","name":"Jack Brockhoff Foundation","doi-asserted-by":"crossref","award":["JBF 4867-2021"],"award-info":[{"award-number":["JBF 4867-2021"]}],"id":[{"id":"10.13039\/100012698","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"crossref","award":["APP1142938,APP1194329"],"award-info":[{"award-number":["APP1142938,APP1194329"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"crossref","award":["R01HL118567,R01HL127564,R01HL135242,R01HL142711,R01HL148050,R01HL148071,R01HL148565,R01HL151152,R01HL151283"],"award-info":[{"award-number":["R01HL118567,R01HL127564,R01HL135242,R01HL142711,R01HL148050,R01HL148071,R01HL148565,R01HL151152,R01HL151283"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"crossref","award":["R01DK125782"],"award-info":[{"award-number":["R01DK125782"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001674","name":"Fondation Leducq","doi-asserted-by":"crossref","award":["TNE-18CVD04"],"award-info":[{"award-number":["TNE-18CVD04"]}],"id":[{"id":"10.13039\/501100001674","id-type":"DOI","asserted-by":"crossref"}]},{"name":"CSL Behring","award":["Centenary Award"],"award-info":[{"award-number":["Centenary Award"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Thromb Haemost"],"published-print":{"date-parts":[[2022,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Hematopoiesis is the process of blood production, essential for the continued supply of immune cells and red blood cells. However, the proliferative nature of hematopoietic stem cells (HSCs) renders them susceptible to developing somatic mutations. HSCs carrying a mutation can gain a selective advantage over normal HSCs and result in hematological disorders. One such disorder is termed clonal hematopoiesis of indeterminate potential (CHIP), a premalignant state associated with aging, where the mutant HSCs are responsible for producing a small portion of mature immune cells in the circulation and subsequently in tissues. People with CHIP have been shown to have an increased risk of mortality due to cardiovascular disease (CVD). Why this occurs is under rigorous investigation, but the majority of the studies to date have suggested that increased atherosclerosis is due to heightened inflammatory cytokine release from mutant lesional macrophages. However, given CHIP is driven by several mutations, other hematopoietic lineages can be altered to promote CVD. In this review we explore the relationship between mutations in genes causing CHIP and atherothrombotic disorders, along with potential mechanisms of enhanced clonal outgrowth and potential therapies and strategies to slow CHIP progression.<\/jats:p>","DOI":"10.1055\/a-1830-2147","type":"journal-article","created":{"date-parts":[[2022,4,21]],"date-time":"2022-04-21T00:28:15Z","timestamp":1650500895000},"page":"1435-1442","source":"Crossref","is-referenced-by-count":4,"title":["Hematopoiesis of Indeterminate Potential and Atherothrombotic Risk"],"prefix":"10.1055","volume":"122","author":[{"given":"Andrew J.","family":"Murphy","sequence":"additional","affiliation":[{"name":"Haematopoiesis and Leukocyte Biology, Baker Heart and Diabetes Institute, Melbourne, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dragana","family":"Dragoljevic","sequence":"additional","affiliation":[{"name":"Haematopoiesis and Leukocyte Biology, Baker Heart and Diabetes Institute, Melbourne, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pradeep","family":"Natarajan","sequence":"additional","affiliation":[{"name":"Cardiology Division, Department of Medicine, Cardiovascular Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, United States"},{"name":"Department of Medical and Population Genetics and the Cardiovascular Disease Initiative, Broad Institute of Harvard and MIT, Cambridge, Massachusetts, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nan","family":"Wang","sequence":"additional","affiliation":[{"name":"Division of Molecular Medicine, Department of Medicine, Columbia University Medical Center, New York, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2022,6,18]]},"reference":[{"issue":"05","key":"ref1","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1038\/nri3433","article-title":"The ageing haematopoietic stem cell compartment","volume":"13","author":"H Geiger","year":"2013","journal-title":"Nat Rev Immunol"},{"issue":"14","key":"ref2","first-page":"1590","article-title":"Clonal hematopoiesis: mechanisms driving dominance of stem cell clones","volume":"136","author":"G A Challen","year":"2020","journal-title":"Blood"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1038\/s41586-018-0497-0","article-title":"Population dynamics of normal human blood inferred from somatic mutations","volume":"561","author":"H Lee-Six","year":"2018","journal-title":"Nature"},{"issue":"09","key":"ref4","doi-asserted-by":"crossref","first-page":"2308","DOI":"10.1016\/j.celrep.2018.11.014","article-title":"Somatic mutations reveal lineage relationships and age-related mutagenesis in human hematopoiesis","volume":"25","author":"F G Osorio","year":"2018","journal-title":"Cell Rep"},{"issue":"11","key":"ref5","doi-asserted-by":"crossref","first-page":"1179","DOI":"10.1038\/ng.2413","article-title":"Recurrent somatic TET2 mutations in normal elderly individuals with clonal hematopoiesis","volume":"44","author":"L Busque","year":"2012","journal-title":"Nat Genet"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1038\/nature13038","article-title":"Identification of pre-leukaemic haematopoietic stem cells in acute leukaemia","volume":"506","author":"L I Shlush","year":"2014","journal-title":"Nature"},{"issue":"02","key":"ref7","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1016\/j.cell.2012.06.023","article-title":"The origin and evolution of mutations in acute myeloid leukemia","volume":"150","author":"J S Welch","year":"2012","journal-title":"Cell"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"1449","DOI":"10.1126\/science.aay9333","article-title":"The evolutionary dynamics and fitness landscape of clonal hematopoiesis","volume":"367","author":"C J Watson","year":"2020","journal-title":"Science"},{"issue":"07","key":"ref9","doi-asserted-by":"crossref","first-page":"e001926","DOI":"10.1161\/CIRCGEN.118.001926","article-title":"Clonal hematopoiesis: somatic mutations in blood cells and atherosclerosis","volume":"11","author":"P Natarajan","year":"2018","journal-title":"Circ Genom Precis Med"},{"issue":"01","key":"ref10","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1182\/blood-2015-03-631747","article-title":"Clonal hematopoiesis of indeterminate potential and its distinction from myelodysplastic syndromes","volume":"126","author":"D P Steensma","year":"2015","journal-title":"Blood"},{"issue":"02","key":"ref11","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1161\/CIRCULATIONAHA.119.044362","article-title":"Genetic interleukin 6 signaling deficiency attenuates cardiovascular risk in clonal hematopoiesis","volume":"141","author":"A G Bick","year":"2020","journal-title":"Circulation"},{"issue":"26","key":"ref12","doi-asserted-by":"crossref","first-page":"2477","DOI":"10.1056\/NEJMoa1409405","article-title":"Clonal hematopoiesis and blood-cancer risk inferred from blood DNA sequence","volume":"371","author":"G Genovese","year":"2014","journal-title":"N Engl J Med"},{"issue":"26","key":"ref13","doi-asserted-by":"crossref","first-page":"2488","DOI":"10.1056\/NEJMoa1408617","article-title":"Age-related clonal hematopoiesis associated with adverse outcomes","volume":"371","author":"S Jaiswal","year":"2014","journal-title":"N Engl J Med"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"12484","DOI":"10.1038\/ncomms12484","article-title":"Clonal haematopoiesis harbouring AML-associated mutations is ubiquitous in healthy adults","volume":"7","author":"A L Young","year":"2016","journal-title":"Nat Commun"},{"issue":"03","key":"ref15","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1038\/s41569-019-0247-5","article-title":"Clonal haematopoiesis: connecting ageing and inflammation in cardiovascular disease","volume":"17","author":"S Jaiswal","year":"2020","journal-title":"Nat Rev Cardiol"},{"issue":"08","key":"ref16","doi-asserted-by":"crossref","first-page":"13","DOI":"10.3390\/cancers13081968","article-title":"Myelodysplasia syndrome, clonal hematopoiesis and cardiovascular disease","volume":"13","author":"C B Veiga","year":"2021","journal-title":"Cancers (Basel)"},{"issue":"05","key":"ref17","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1016\/j.stem.2007.10.003","article-title":"Hematopoietic fingerprints: an expression database of stem cells and their progeny","volume":"1","author":"S M Chambers","year":"2007","journal-title":"Cell Stem Cell"},{"issue":"04","key":"ref18","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1038\/s41588-020-0595-4","article-title":"DNA methylation disruption reshapes the hematopoietic differentiation landscape","volume":"52","author":"F Izzo","year":"2020","journal-title":"Nat Genet"},{"issue":"09","key":"ref19","doi-asserted-by":"crossref","first-page":"1014","DOI":"10.1038\/ng.3610","article-title":"DNMT3A and TET2 compete and cooperate to repress lineage-specific transcription factors in hematopoietic stem cells","volume":"48","author":"X Zhang","year":"2016","journal-title":"Nat Genet"},{"issue":"01","key":"ref20","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1001\/jamacardio.2018.3965","article-title":"Association of mutations contributing to clonal hematopoiesis with prognosis in chronic ischemic heart failure","volume":"4","author":"L Dorsheimer","year":"2019","journal-title":"JAMA Cardiol"},{"issue":"02","key":"ref21","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1056\/NEJMoa1701719","article-title":"Clonal hematopoiesis and risk of atherosclerotic cardiovascular disease","volume":"377","author":"S Jaiswal","year":"2017","journal-title":"N Engl J Med"},{"issue":"14","key":"ref22","doi-asserted-by":"crossref","first-page":"1747","DOI":"10.1016\/j.jacc.2021.02.028","article-title":"Clonal hematopoiesis and risk of progression of heart failure with reduced left ventricular ejection fraction","volume":"77","author":"D A Pascual-Figal","year":"2021","journal-title":"J Am Coll Cardiol"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"842","DOI":"10.1126\/science.aag1381","article-title":"Clonal hematopoiesis associated with TET2 deficiency accelerates atherosclerosis development in mice","volume":"355","author":"J J Fuster","year":"2017","journal-title":"Science"},{"issue":"10","key":"ref24","doi-asserted-by":"crossref","first-page":"1170","DOI":"10.1001\/jamacardio.2020.2468","article-title":"Association of clonal hematopoiesis of indeterminate potential with inflammatory gene expression in patients with severe degenerative aortic valve stenosis or chronic postischemic heart failure","volume":"5","author":"W T Abplanalp","year":"2020","journal-title":"JAMA Cardiol"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1038\/s41586-020-2819-2","article-title":"Inherited causes of clonal haematopoiesis in 97,691 whole genomes","volume":"586","author":"A G Bick","year":"2020","journal-title":"Nature"},{"issue":"05","key":"ref26","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1182\/blood.2019001113","article-title":"Prevalence and phenotypes of JAK2 V617F and calreticulin mutations in a Danish general population","volume":"134","author":"S Cordua","year":"2019","journal-title":"Blood"},{"issue":"04","key":"ref27","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1016\/j.jacc.2019.05.045","article-title":"Clonal hematopoiesis of indeterminate potential reshapes age-related CVD: JACC review topic of the week","volume":"74","author":"S A Khetarpal","year":"2019","journal-title":"J Am Coll Cardiol"},{"issue":"12","key":"ref28","doi-asserted-by":"crossref","first-page":"1758","DOI":"10.1038\/ng.3977","article-title":"Exome-wide association study of plasma lipids in >300,000 individuals","volume":"49","author":"D J Liu","year":"2017","journal-title":"Nat Genet"},{"issue":"11","key":"ref29","doi-asserted-by":"crossref","first-page":"e35","DOI":"10.1161\/CIRCRESAHA.118.313283","article-title":"Macrophage inflammation, erythrophagocytosis, and accelerated atherosclerosis in Jak V617F mice","volume":"123","author":"W Wang","year":"2018","journal-title":"Circ Res"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1038\/s41586-021-03341-5","article-title":"The AIM2 inflammasome exacerbates atherosclerosis in clonal haematopoiesis","volume":"592","author":"T P Fidler","year":"2021","journal-title":"Nature"},{"issue":"10","key":"ref31","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1038\/s41577-021-00580-5","article-title":"Immune-based therapies in cardiovascular and metabolic diseases: past, present and future","volume":"21","author":"A J Murphy","year":"2021","journal-title":"Nat Rev Immunol"},{"issue":"12","key":"ref32","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.1056\/NEJMoa1707914","article-title":"Antiinflammatory therapy with canakinumab for atherosclerotic disease","volume":"377","author":"P M Ridker","year":"2017","journal-title":"N Engl J Med"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1038\/nature04516","article-title":"Gout-associated uric acid crystals activate the NALP3 inflammasome","volume":"440","author":"F Martinon","year":"2006","journal-title":"Nature"},{"issue":"05","key":"ref34","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1038\/ni.2550","article-title":"Microtubule-driven spatial arrangement of mitochondria promotes activation of the NLRP3 inflammasome","volume":"14","author":"T Misawa","year":"2013","journal-title":"Nat Immunol"},{"issue":"26","key":"ref35","doi-asserted-by":"crossref","first-page":"2497","DOI":"10.1056\/NEJMoa1912388","article-title":"Efficacy and safety of low-dose colchicine after myocardial infarction","volume":"381","author":"J C Tardif","year":"2019","journal-title":"N Engl J Med"},{"issue":"26","key":"ref36","doi-asserted-by":"crossref","first-page":"2562","DOI":"10.1056\/NEJMe1914378","article-title":"Inflammation as a treatment target after acute myocardial infarction","volume":"381","author":"L K Newby","year":"2019","journal-title":"N Engl J Med"},{"issue":"05","key":"ref37","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1001\/jamacardio.2022.0386","article-title":"TET2-driven clonal hematopoiesis and response to canakinumab: an exploratory analysis of the CANTOS randomized clinical trial","volume":"7","author":"E C Svensson","year":"2022","journal-title":"JAMA Cardiol"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"1214","DOI":"10.1016\/S0140-6736(12)60110-X","article-title":"The interleukin-6 receptor as a target for prevention of coronary heart disease: a Mendelian randomisation analysis","volume":"379","author":"Interleukin-6 Receptor Mendelian Randomisation Analysis (IL6R MR) Consortium","year":"2012","journal-title":"Lancet"},{"issue":"09","key":"ref39","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1001\/jamacardio.2018.2287","article-title":"Association of interleukin 6 receptor variant with cardiovascular disease effects of interleukin 6 receptor blocking therapy: a phenome-wide association study","volume":"3","author":"T Cai","year":"2018","journal-title":"JAMA Cardiol"},{"issue":"08","key":"ref40","doi-asserted-by":"crossref","first-page":"2020","DOI":"10.3324\/haematol.2019.235994","article-title":"Clonal hematopoietic mutations linked to platelet traits and the risk of thrombosis or bleeding","volume":"105","author":"A Veninga","year":"2020","journal-title":"Haematologica"},{"issue":"01","key":"ref41","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/j.thromres.2013.05.003","article-title":"ADP-induced platelet aggregation and thrombin generation are increased in Essential Thrombocythemia and Polycythemia Vera","volume":"132","author":"M Panova-Noeva","year":"2013","journal-title":"Thromb Res"},{"issue":"04","key":"ref42","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1002\/ajh.21974","article-title":"Platelet-induced thrombin generation by the calibrated automated thrombogram assay is increased in patients with essential thrombocythemia and polycythemia vera","volume":"86","author":"M Panova-Noeva","year":"2011","journal-title":"Am J Hematol"},{"issue":"22","key":"ref43","doi-asserted-by":"crossref","first-page":"2168","DOI":"10.1056\/NEJMra1406186","article-title":"Myeloproliferative neoplasms","volume":"376","author":"J L Spivak","year":"2017","journal-title":"N Engl J Med"},{"issue":"436","key":"ref44","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1126\/scitranslmed.aan8292","article-title":"Increased neutrophil extracellular trap formation promotes thrombosis in myeloproliferative neoplasms","volume":"10","author":"O Wolach","year":"2018","journal-title":"Sci Transl Med"},{"issue":"11","key":"ref45","doi-asserted-by":"crossref","first-page":"2067","DOI":"10.1038\/sj.leu.2404379","article-title":"JAK2V617F mutational frequency in polycythemia vera: 100%, >90%, less?","volume":"20","author":"S Verstovsek","year":"2006","journal-title":"Leukemia"},{"issue":"05","key":"ref46","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1055\/s-2003-44552","article-title":"Hyperviscosity in polycythemia vera and other red cell abnormalities","volume":"29","author":"H C Kwaan","year":"2003","journal-title":"Semin Thromb Hemost"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"1532","DOI":"10.1126\/science.1092385","article-title":"Neutrophil extracellular traps kill bacteria","volume":"303","author":"V Brinkmann","year":"2004","journal-title":"Science"},{"issue":"21","key":"ref48","doi-asserted-by":"crossref","first-page":"8674","DOI":"10.1073\/pnas.1301059110","article-title":"Neutrophil histone modification by peptidylarginine deiminase 4 is critical for deep vein thrombosis in mice","volume":"110","author":"K Martinod","year":"2013","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"08","key":"ref49","doi-asserted-by":"crossref","first-page":"2032","DOI":"10.1161\/ATVBAHA.113.301627","article-title":"Elevated levels of circulating DNA and chromatin are independently associated with severe coronary atherosclerosis and a prothrombotic state","volume":"33","author":"J I Borissoff","year":"2013","journal-title":"Arterioscler Thromb Vasc Biol"},{"issue":"10","key":"ref50","doi-asserted-by":"crossref","first-page":"1517","DOI":"10.3324\/haematol.2012.082560","article-title":"Increased reactive oxygen species production and p47phox phosphorylation in neutrophils from myeloproliferative disorders patients with JAK2 (V617F) mutation","volume":"98","author":"M Hurtado-Nedelec","year":"2013","journal-title":"Haematologica"},{"issue":"04","key":"ref51","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1007\/s11239-016-1398-4","article-title":"Persistent neutrophilia is a marker for an increased risk of venous thrombosis","volume":"42","author":"M Kushnir","year":"2016","journal-title":"J Thromb Thrombolysis"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"38738","DOI":"10.1038\/srep38738","article-title":"Neutrophil extracellular trap formation and circulating nucleosomes in patients with chronic myeloproliferative neoplasms","volume":"6","author":"C P Marin Oyarz\u00fan","year":"2016","journal-title":"Sci Rep"},{"issue":"23","key":"ref53","doi-asserted-by":"crossref","first-page":"3787","DOI":"10.1182\/blood-2013-06-501452","article-title":"JAK2V617F leads to intrinsic changes in platelet formation and reactivity in a knock-in mouse model of essential thrombocythemia","volume":"122","author":"C M Hobbs","year":"2013","journal-title":"Blood"},{"issue":"07","key":"ref54","doi-asserted-by":"crossref","first-page":"1136","DOI":"10.1182\/blood-2013-10-530832","article-title":"Hemostatic disorders in a JAK2V617F-driven mouse model of myeloproliferative neoplasm","volume":"124","author":"L Lamrani","year":"2014","journal-title":"Blood"},{"issue":"06","key":"ref55","doi-asserted-by":"crossref","first-page":"2295","DOI":"10.1073\/pnas.1312148111","article-title":"JAK2V617F-positive endothelial cells contribute to clotting abnormalities in myeloproliferative neoplasms","volume":"111","author":"S L Etheridge","year":"2014","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"08","key":"ref56","first-page":"2832","article-title":"Lnk controls mouse hematopoietic stem cell self-renewal and quiescence through direct interactions with JAK2","volume":"118","author":"A Bersenev","year":"2008","journal-title":"J Clin Invest"},{"issue":"06","key":"ref57","doi-asserted-by":"crossref","first-page":"e91","DOI":"10.1161\/CIRCRESAHA.116.308955","article-title":"LNK\/SH2B3 loss of function promotes atherosclerosis and thrombosis","volume":"119","author":"W Wang","year":"2016","journal-title":"Circ Res"},{"issue":"24","key":"ref58","doi-asserted-by":"crossref","first-page":"1940","DOI":"10.1161\/CIRCULATIONAHA.121.056414","article-title":"Oxidized phospholipids promote NETosis and arterial thrombosis in LNK(SH2B3) deficiency","volume":"144","author":"H Dou","year":"2021","journal-title":"Circulation"},{"issue":"01","key":"ref59","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1038\/ng.2480","article-title":"Large-scale association analysis identifies new risk loci for coronary artery disease","volume":"45","author":"P Deloukas","year":"2013","journal-title":"Nat Genet"},{"issue":"08","key":"ref60","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1182\/blood-2015-06-652941","article-title":"Germ line variants predispose to both JAK2 V617F clonal hematopoiesis and myeloproliferative neoplasms","volume":"128","author":"D A Hinds","year":"2016","journal-title":"Blood"},{"issue":"04","key":"ref61","doi-asserted-by":"crossref","first-page":"e003003","DOI":"10.1161\/CIRCGEN.120.003003","article-title":"Multiple somatic mutations for clonal hematopoiesis are associated with increased mortality in patients with chronic heart failure","volume":"13","author":"S Cremer","year":"2020","journal-title":"Circ Genom Precis Med"},{"issue":"01","key":"ref62","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.jacc.2021.04.085","article-title":"Supplemental association of clonal hematopoiesis with incident heart failure","volume":"78","author":"B Yu","year":"2021","journal-title":"J Am Coll Cardiol"},{"issue":"06","key":"ref63","doi-asserted-by":"crossref","first-page":"1006","DOI":"10.1038\/s41591-021-01357-y","article-title":"HIV is associated with an increased risk of age-related clonal hematopoiesis among older adults","volume":"27","author":"N J Dharan","year":"2021","journal-title":"Nat Med"},{"issue":"05","key":"ref64","doi-asserted-by":"crossref","first-page":"1348","DOI":"10.1016\/j.cell.2021.01.049","article-title":"Increased stem cell proliferation in atherosclerosis accelerates clonal hematopoiesis","volume":"184","author":"A Heyde","year":"2021","journal-title":"Cell"},{"issue":"21","key":"ref66","doi-asserted-by":"crossref","first-page":"4845","DOI":"10.1182\/blood-2011-06-362830","article-title":"Increased incidence of non-Hodgkin lymphoma, leukemia, and myeloma in patients with diabetes mellitus type 2: a meta-analysis of observational studies","volume":"119","author":"J J Castillo","year":"2012","journal-title":"Blood"},{"issue":"07","key":"ref67","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1111\/j.1464-5491.2010.03011.x","article-title":"Cancer risk among patients hospitalized for Type 1 diabetes mellitus: a population-based cohort study in Sweden","volume":"27","author":"X Shu","year":"2010","journal-title":"Diabet Med"},{"issue":"01","key":"ref68","first-page":"131","article-title":"Hyperglycemia cooperates with Tet2 heterozygosity to induce leukemia driven by proinflammatory cytokine-induced lncRNA Morrbid","volume":"131","author":"Z Cai","year":"2021","journal-title":"J Clin Invest"},{"issue":"04","key":"ref69","doi-asserted-by":"crossref","first-page":"108326","DOI":"10.1016\/j.celrep.2020.108326","article-title":"TET2-loss-of-function-driven clonal hematopoiesis exacerbates experimental insulin resistance in aging and obesity","volume":"33","author":"J J Fuster","year":"2020","journal-title":"Cell Rep"},{"issue":"09","key":"ref70","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1001\/jamacardio.2021.1678","article-title":"Association of diet quality with prevalence of clonal hematopoiesis and adverse cardiovascular events","volume":"6","author":"R Bhattacharya","year":"2021","journal-title":"JAMA Cardiol"},{"issue":"05","key":"ref71","doi-asserted-by":"crossref","first-page":"e018789","DOI":"10.1161\/JAHA.120.018789","article-title":"Healthy lifestyle and clonal hematopoiesis of indeterminate potential: results from the women's health initiative","volume":"10","author":"B Haring","year":"2021","journal-title":"J Am Heart Assoc"},{"issue":"07","key":"ref72","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1016\/j.tem.2020.02.005","article-title":"Interplay between clonal hematopoiesis of indeterminate potential and metabolism","volume":"31","author":"M KS Lee","year":"2020","journal-title":"Trends Endocrinol Metab"},{"issue":"05","key":"ref73","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1016\/j.cmet.2014.03.029","article-title":"Adipose tissue macrophages promote myelopoiesis and monocytosis in obesity","volume":"19","author":"P R Nagareddy","year":"2014","journal-title":"Cell Metab"},{"issue":"05","key":"ref74","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1016\/j.cmet.2013.04.001","article-title":"Hyperglycemia promotes myelopoiesis and impairs the resolution of atherosclerosis","volume":"17","author":"P R Nagareddy","year":"2013","journal-title":"Cell Metab"},{"key":"ref75","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1038\/s41586-018-0350-5","article-title":"Glucose-regulated phosphorylation of TET2 by AMPK reveals a pathway linking diabetes to cancer","volume":"559","author":"D Wu","year":"2018","journal-title":"Nature"},{"issue":"01","key":"ref76","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41375-020-0954-2","article-title":"Fedratinib, a newly approved treatment for patients with myeloproliferative neoplasm-associated myelofibrosis","volume":"35","author":"M Talpaz","year":"2021","journal-title":"Leukemia"},{"issue":"02","key":"ref77","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1007\/s10557-020-06943-9","article-title":"Inhibition of JAK2 suppresses myelopoiesis and atherosclerosis in Apoe-\/- mice","volume":"34","author":"Y Tang","year":"2020","journal-title":"Cardiovasc Drugs Ther"},{"issue":"16","key":"ref78","doi-asserted-by":"crossref","first-page":"1509","DOI":"10.1056\/NEJMoa1805819","article-title":"Effect of aspirin on cardiovascular events and bleeding in the healthy elderly","volume":"379","author":"J J McNeil","year":"2018","journal-title":"N Engl J Med"},{"issue":"08","key":"ref79","doi-asserted-by":"crossref","first-page":"926","DOI":"10.3324\/haematol.2016.146654","article-title":"Antiplatelet therapy versus observation in low-risk essential thrombocythemia with a CALR mutation","volume":"101","author":"A Alvarez-Larr\u00e1n","year":"2016","journal-title":"Haematologica"},{"key":"ref80","doi-asserted-by":"crossref","first-page":"1373","DOI":"10.3389\/fimmu.2019.01373","article-title":"Platelets as mediators of thromboinflammation in chronic myeloproliferative neoplasms","volume":"10","author":"C P Marin Oyarz\u00fan","year":"2019","journal-title":"Front Immunol"},{"issue":"08","key":"ref81","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1038\/nri.2016.63","article-title":"Innate sensing of oxidation-specific epitopes in health and disease","volume":"16","author":"C J Binder","year":"2016","journal-title":"Nat Rev Immunol"}],"container-title":["Thrombosis and Haemostasis"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/a-1830-2147.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,8,28]],"date-time":"2022-08-28T22:55:43Z","timestamp":1661727343000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/a-1830-2147"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,4,20]]},"references-count":80,"journal-issue":{"issue":"09","published-online":{"date-parts":[[2022,8,28]]},"published-print":{"date-parts":[[2022,9]]}},"URL":"https:\/\/doi.org\/10.1055\/a-1830-2147","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["0340-6245","2567-689X"],"issn-type":[{"value":"0340-6245","type":"print"},{"value":"2567-689X","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2022,4,20]]},"published":{"date-parts":[[2022,4,20]]}}}