{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T08:33:56Z","timestamp":1740126836036,"version":"3.37.3"},"reference-count":57,"publisher":"Georg Thieme Verlag KG","issue":"03","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Zentralbl Chir"],"published-print":{"date-parts":[[2022,6]]},"abstract":"<jats:title>Zusammenfassung<\/jats:title><jats:p>Neuroendokrine Neoplasien (NEN) bilden eine heterogene Gruppe maligner Tumoren, die \u00fcberwiegend dem gastro-entero-pankreatischen System (GEP) zuzuordnen sind. Hierbei sind D\u00fcnndarm und\n          Pankreas die h\u00e4ufigsten Organe f\u00fcr Prim\u00e4rtumoren, die Leber stellt den dominanten Metastasierungsort dar. Da viele Patient*innen lange asymptomatisch bleiben, f\u00fchren oftmals zuf\u00e4llig\n          diagnostizierte Lebermetastasen oder ein Ileus zur Diagnose. Die einzige kurative Therapieoption stellt die komplette Entfernung von Primarius und Metastasen dar. Besonders im Falle der\n          metastasierten Erkrankung sollten die vorhandenen Therapieoptionen immer im interdisziplin\u00e4ren Tumorboard mit Spezialisten*innen aus Gastroenterologie, (Leber-)Chirurgie, Radiologie,\n          Nuklearmedizin, Radiotherapie, Pathologie und Endokrinologie evaluiert werden. Durch die Kombination der verschiedenen Therapieverfahren kann auch f\u00fcr Patient*innen mit fortgeschrittener\n          Erkrankung eine jahrelange Prognose bei guter Lebensqualit\u00e4t erreicht werden. Wichtig f\u00fcr die Therapieentscheidung sind neben patientenindividuellen Faktoren der Differenzierungsgrad des\n          Tumors, dessen hormonelle Sekretion, das Metastasierungsmuster und der Erkrankungsverlauf. Die Behandlung von Lebermetastasen umfasst neben den unterschiedlichen chirurgischen Strategien die\n          lokal-ablativen radiologischen und nuklearmedizinischen Verfahren, die als Erg\u00e4nzung zu den systemischen Therapien zur Verf\u00fcgung stehen.<\/jats:p>","DOI":"10.1055\/a-1830-8442","type":"journal-article","created":{"date-parts":[[2022,6,15]],"date-time":"2022-06-15T22:40:32Z","timestamp":1655332832000},"page":"270-280","source":"Crossref","is-referenced-by-count":1,"title":["Differenzierte Therapiestrategie bei Lebermetastasen gastro-entero-pankreatischer Neuroendokriner Neoplasien"],"prefix":"10.1055","volume":"147","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3676-047X","authenticated-orcid":false,"given":"Martina T.","family":"Mogl","sequence":"additional","affiliation":[{"name":"Chirurgische Klinik Campus Charit\u00e9 Mitte | Campus Virchow-Klinikum, Charit\u00e9 Universit\u00e4tsmedizin Berlin, Berlin, 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