{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T16:30:37Z","timestamp":1782837037638,"version":"3.54.5"},"reference-count":31,"publisher":"Georg Thieme Verlag KG","issue":"11","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int J Sports Med"],"published-print":{"date-parts":[[2022,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>This study evaluated the feasibility and efficacy of voluntary sustained\n                    hyperventilation during rapid ascent to high altitude for the prevention of\n                    acute mountain sickness (AMS). Study subjects (n=32) were volunteer\n                    participants in a 2-day expedition to Mount Leoneras (4954 m), starting at 2800m\n                    (base camp at 4120 m). Subjects were randomized to either: 1) an intervention\n                    group using the voluntary hyperventilation (VH) technique targeting an end-tidal\n                        CO2 (ETCO2)&lt;20 mmHg; or 2) a group using\n                    acetazolamide (AZ). During the expedition, respiratory rate (28\u00b120 vs.\n                    18\u00b15 breaths\/min, mean\u00b1SD, P&lt;0.01) and\n                        SpO2 (95%\u00b14% vs.\n                    89%\u00b15%, mean\u00b1SD, P&lt;0.01) were higher,\n                    and ETCO2 (17\u00b14 vs. 26\u00b14 mmHg, mean\u00b1SD,\n                    P&lt;0.01) was lower in the VH group compared to the AZ group \u2013 as\n                    repeatedly measured at equal fixed intervals during the ascent \u2013 showing\n                    the feasibility of the VH technique. Regarding efficacy, the incidence of 6\n                    (40%) subjects registering an LLS score\u22653 in the VH group was\n                    non-inferior to the 3 (18%) subjects in the acetazolamide group\n                    (P=0.16, power 28%). Voluntary increase in minute ventilation is\n                    a feasible technique, but \u2013 despite the underpowered non-inferiority in\n                    this small-scale proof-of-concept trial \u2013 it is not likely to be as\n                    effective as acetazolamide to prevent AMS.<\/jats:p>","DOI":"10.1055\/a-1832-0279","type":"journal-article","created":{"date-parts":[[2022,6,27]],"date-time":"2022-06-27T23:09:31Z","timestamp":1656371371000},"page":"971-977","source":"Crossref","is-referenced-by-count":2,"title":["Voluntary Increase of Minute Ventilation for Prevention of Acute\n                    Mountain Sickness"],"prefix":"10.1055","volume":"43","author":[{"given":"Sebastian","family":"Drago","sequence":"additional","affiliation":[{"name":"Orthopedic Surgery, Hospital del Trabajador, Santiago, Chile"},{"name":"Faculty of Medicine, Universidad de Los Andes, Santiago, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Campod\u00f3nico","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Universidad de Los Andes, Santiago, Chile"},{"name":"Grupo de rescate m\u00e9dico en monta\u00f1a (GREMM), Santiago,\n                    Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mario","family":"Sandoval","sequence":"additional","affiliation":[{"name":"Sport Medicine Department; Cl\u00ednica MEDS, Santiago,\n                    Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Remco","family":"Berendsen","sequence":"additional","affiliation":[{"name":"Anesthesia, Leiden University Medical Center, Leiden,\n                    Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geert Alexander","family":"Buijze","sequence":"additional","affiliation":[{"name":"Orthopaedic Surgery and Sports Medicine, Clinique\n                    G\u00e9n\u00e9rale, Annecy, France"},{"name":"Orthopaedic Surgery, Lapeyronie Hospital, Montpellier University\n                    Medical Center, Montpellier, France"},{"name":"Orthopaedic Surgery, Amsterdam University Medical Center, Amsterdam,\n                    Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2022,6,27]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1164\/rccm.201108-1396OC","article-title":"Physiological risk factors for severe high-altitude illness: a prospective\n                    cohort study","volume":"185","author":"J-P Richalet","year":"2012","journal-title":"Am J Respir Crit Care Med"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"e100642","DOI":"10.1371\/journal.pone.0100642","article-title":"Risk prediction score for severe high altitude illness: a cohort study","volume":"9","author":"F Canou\u00ef-Poitrine","year":"2014","journal-title":"PloS One"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"1407","DOI":"10.1152\/jappl.1986.60.4.1407","article-title":"Low acute hypoxic ventilatory response and hypoxic depression in acute altitude\n                    sickness","volume":"60","author":"L G Moore","year":"1986","journal-title":"J Appl Physiol (1985)"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1183\/09031936.06.00015805","article-title":"Hypoxic ventilatory response in successful extreme altitude climbers","volume":"27","author":"L Bernardi","year":"2006","journal-title":"Eur Respir J"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1007\/s00421-006-0373-8","article-title":"Reduced hypoxic ventilatory response with preserved blood oxygenation in yoga\n                    trainees and Himalayan Buddhist monks at altitude: evidence of a different\n                    adaptive strategy?","volume":"99","author":"L Bernardi","year":"2007","journal-title":"Eur J Appl Physiol"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1089\/15270290260512846","article-title":"Hypoxic ventilatory response, ventilation, gas exchange, and fluid balance in\n                    acute mountain sickness","volume":"3","author":"P B\u00e4rtsch","year":"2002","journal-title":"High Alt Med Biol"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"S3","DOI":"10.1016\/j.wem.2019.04.006","article-title":"Wilderness Medical Society clinical practice guidelines for the prevention and\n                    treatment of acute altitude illness: 2019 update","volume":"30","author":"A M Luks","year":"2019","journal-title":"Wilderness Environ Med"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1152\/japplphysiol.00655.2019","article-title":"Acetazolamide does not alter endurance exercise performance at 3,500-m\n                    altitude","volume":"128","author":"K E Bradbury","year":"2020","journal-title":"J Appl Physiol (1985)"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"e000302","DOI":"10.1136\/bmjsem-2017-000302","article-title":"Acetazolamide reduces exercise capacity following a 5-day ascent to 4559 m in a\n                    randomised study","volume":"4","author":"A R Bradwell","year":"2018","journal-title":"BMJ Open Sport Exerc Med"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1016\/j.wem.2014.04.003","article-title":"Exercise limitation of acetazolamide at altitude (3459 m)","volume":"25","author":"A R Bradwell","year":"2014","journal-title":"Wilderness Environ Med"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1016\/j.wem.2018.06.011","article-title":"The effects of acetazolamide on exercise performance at sea level and in hypoxic\n                    environments: a review","volume":"29","author":"A M Posch","year":"2018","journal-title":"Wilderness Environ Med"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1016\/j.wem.2014.04.009","article-title":"Controlled hyperventilation after training may accelerate altitude\n                    acclimatization","volume":"25","author":"G A Buijze","year":"2014","journal-title":"Wilderness Environ Med"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"1313","DOI":"10.1152\/japplphysiol.01572.2005","article-title":"Mechanisms of action of acetazolamide in the prophylaxis and treatment of acute\n                    mountain sickness","volume":"102","author":"D E Leaf","year":"2007","journal-title":"J Appl Physiol (1985)"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1089\/ham.2006.7.17","article-title":"Acetazolamide 125 mg BD is not significantly different from 375 mg BD in the\n                    prevention of acute mountain sickness: the prophylactic acetazolamide dosage\n                    comparison for efficacy (PACE) trial","volume":"7","author":"B Basnyat","year":"2006","journal-title":"High Alt Med Biol"},{"key":"ref16","first-page":"377","article-title":"Psychophysical bases of perceived exertion","volume":"14","author":"G A Borg","year":"1982","journal-title":"Med Sci Sports Exerc"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1089\/ham.2017.0164","article-title":"The 2018 Lake Louise Acute Mountain Sickness Score","volume":"19","author":"R C Roach","year":"2018","journal-title":"High Alt Med Biol"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1111\/j.1708-8305.2012.00629.x","article-title":"Acetazolamide for the prevention of acute mountain sickness \u2013 a\n                    systematic review and meta-analysis","volume":"19","author":"N D Ritchie","year":"2012","journal-title":"J Travel 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Physiol"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1152\/japplphysiol.00443.2015","article-title":"Pharmacology of acute mountain sickness: old drugs and newer thinking","volume":"120","author":"E R Swenson","year":"2016","journal-title":"J Appl Physiol (1985)"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"L1002","DOI":"10.1152\/ajplung.00161.2006","article-title":"Inhibition of hypoxia-induced calcium responses in pulmonary arterial smooth\n                    muscle by acetazolamide is independent of carbonic anhydrase inhibition","volume":"292","author":"L A Shimoda","year":"2007","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"1151","DOI":"10.1159\/000354515","article-title":"Hypoxia-inducible factor-1\u03b1 dependent pathways mediate the\n                    renoprotective role of acetazolamide against renal ischemia-reperfusion\n                    injury","volume":"32","author":"Y An","year":"2013","journal-title":"Cell Physiol Biochem"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"964","DOI":"10.1056\/NEJM195512012532205","article-title":"Some observations on acclimatization to high altitude","volume":"253","author":"C S Houston","year":"1955","journal-title":"N Engl J Med"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.wem.2014.10.001","article-title":"Cerebral hemodynamics at altitude: effects of hyperventilation and\n                    acclimatization on cerebral blood flow and oxygenation","volume":"26","author":"M R Sanborn","year":"2015","journal-title":"Wilderness Environ Med"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1007\/s11325-015-1195-x","article-title":"Diagnosis and prediction of the occurrence of acute mountain sickness measuring\n                    oxygen saturation \u2013 independent of absolute 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