{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,2]],"date-time":"2025-12-02T15:06:36Z","timestamp":1764687996771,"version":"3.37.3"},"reference-count":35,"publisher":"Georg Thieme Verlag KG","issue":"10","funder":[{"name":"Internal grant from N\u00eemes University Hospital dedicated to clinical research projects on cohorts."}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Thromb Haemost"],"published-print":{"date-parts":[[2022,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n          Background\u2003Few data are available on thrombotic outcomes during pregnancy and puerperium occurring after an initial provoked venous thromboembolic (VTE) event.<\/jats:p><jats:p>\n          Objectives\u2003To describe thrombotic outcomes during pregnancy after a first combined oral contraceptive (COC)-associated VTE and the factors associated with recurrence.<\/jats:p><jats:p>\n          Methods\u2003This was an international multicentric retrospective study on patients referred for thrombophilia screening from January 1, 2010 to January 1, 2021 following a first COC-associated VTE, including women with neither inherited thrombophilia nor antiphospholipid antibodies and focusing on those who had a subsequent pregnancy under the same thromboprophylaxis treatment. Thrombotic recurrences during pregnancy and puerperium as well as risk factors for recurrence were analyzed.<\/jats:p><jats:p>\n          Results\u2003We included 2,145 pregnant women. A total of 88 thrombotic events, 58 antenatal and 29 postnatal, occurred, mostly during the first trimester of pregnancy and the first 2 weeks of puerperium. Incidence rates were 49.6 (37\u201362) per 1,000 patient-years during pregnancy and 118.7 (78\u2013159) per 1,000 patient-years during puerperium. Focusing on pulmonary embolism, incidence rates were 1.68 (1\u20134) per 1,000 patient-years during pregnancy and 65.5 (35\u201397) per 1,000 patient-years during puerperium.<\/jats:p><jats:p>Risk factors for antenatal recurrences were maternal hypercholesterolemia and birth of a very small-for-gestational-age neonate. A risk factor for postnatal recurrence was the incidence of preeclampsia.<\/jats:p><jats:p>\n          Conclusion\u2003Our multicentric retrospective data show significant rates of VTE recurrence during pregnancy and puerperium in women with a previous VTE event associated with COC, despite a unique low-molecular-weight heparin-based thromboprophylaxis. These results may provide benchmarks and valuable information for designing future randomized controlled trials.<\/jats:p>","DOI":"10.1055\/a-1835-8808","type":"journal-article","created":{"date-parts":[[2022,4,26]],"date-time":"2022-04-26T22:48:20Z","timestamp":1651013300000},"page":"1779-1793","source":"Crossref","is-referenced-by-count":12,"title":["Pregnancy after Combined Oral Contraceptive-Associated Venous Thromboembolism: An International Retrospective Study of Outcomes"],"prefix":"10.1055","volume":"122","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9899-9910","authenticated-orcid":false,"given":"Jean-Christophe","family":"Gris","sequence":"additional","affiliation":[{"name":"Department of Haematology, CHU N\u00eemes, Univ Montpellier, N\u00eemes, France"},{"name":"Faculty of Pharmaceutical and Biological Sciences, Montpellier University, Montpellier, France"},{"name":"UMR UA11 INSERM IDESP, Montpellier University, Montpellier, France"},{"name":"Department of Obstetrics and Gynaecology, I.M. Sechenov First Moscow State Medical University, Moscow, Russian Federation"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4715-1725","authenticated-orcid":false,"given":"Chlo\u00e9","family":"Bourguignon","sequence":"additional","affiliation":[{"name":"Department of Haematology, CHU N\u00eemes, Univ Montpellier, N\u00eemes, France"},{"name":"UMR UA11 INSERM IDESP, Montpellier University, Montpellier, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8808-8841","authenticated-orcid":false,"given":"Sylvie","family":"Bouvier","sequence":"additional","affiliation":[{"name":"Department of Haematology, CHU N\u00eemes, Univ Montpellier, N\u00eemes, France"},{"name":"Faculty of Pharmaceutical and Biological Sciences, Montpellier University, Montpellier, France"},{"name":"UMR UA11 INSERM IDESP, Montpellier University, Montpellier, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2064-4527","authenticated-orcid":false,"given":"Eva","family":"Nouvellon","sequence":"additional","affiliation":[{"name":"Department of Haematology, CHU N\u00eemes, Univ Montpellier, N\u00eemes, France"},{"name":"UMR UA11 INSERM IDESP, Montpellier University, Montpellier, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1853-2721","authenticated-orcid":false,"given":"Jeremy","family":"Laurent","sequence":"additional","affiliation":[{"name":"Department of Haematology, CHU N\u00eemes, Univ Montpellier, N\u00eemes, France"},{"name":"Department of Vascular Medicine, University Hospital, Montpellier, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8527-7783","authenticated-orcid":false,"given":"Antonia","family":"Perez-Martin","sequence":"additional","affiliation":[{"name":"UMR UA11 INSERM IDESP, Montpellier University, Montpellier, France"},{"name":"Department of Vascular Medicine, University Hospital, Montpellier, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3648-0304","authenticated-orcid":false,"given":"Eve","family":"Mousty","sequence":"additional","affiliation":[{"name":"Department of Gynaecology and Obstetrics, CHU N\u00eemes, Univ Montpellier, N\u00eemes, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9459-5698","authenticated-orcid":false,"given":"Mariya","family":"Nikolaeva","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology, Altai State Medical University, Barnaul, Russian Federation"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0725-9686","authenticated-orcid":false,"given":"Jamilya","family":"Khizroeva","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology, I.M. Sechenov First Moscow State Medical University, Moscow, Russian Federation"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8404-1042","authenticated-orcid":false,"given":"Victoria","family":"Bitsadze","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology, I.M. Sechenov First Moscow State Medical University, Moscow, Russian Federation"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7415-4633","authenticated-orcid":false,"given":"Alexander","family":"Makatsariya","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology, I.M. 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A national cohort study","volume":"106","author":"R A Virkus","year":"2011","journal-title":"Thromb Haemost"},{"issue":"03","key":"ref34","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1111\/j.1365-2141.2011.08956.x","article-title":"Risk of first venous thromboembolism in and around pregnancy: a population-based cohort study","volume":"156","author":"A A Sultan","year":"2012","journal-title":"Br J Haematol"},{"issue":"03","key":"ref35","doi-asserted-by":"crossref","first-page":"245","DOI":"10.5937\/jomb0-27106","article-title":"Influence of lipid metabolism disorders on venous thrombosis risk","volume":"40","author":"I Spasi\u0107","year":"2021","journal-title":"J Med Biochem"},{"issue":"17","key":"ref36","doi-asserted-by":"crossref","first-page":"1471","DOI":"10.1161\/CIRCULATIONAHA.114.012749","article-title":"Association between newborn birth weight and the risk of postpartum maternal venous thromboembolism: a population-based case-control study","volume":"131","author":"M Blondon","year":"2015","journal-title":"Circulation"},{"issue":"11","key":"ref37","doi-asserted-by":"crossref","first-page":"3055","DOI":"10.3390\/cells10113055","article-title":"Vascular Dysfunction in Preeclampsia","volume":"10","author":"M A Opichka","year":"2021","journal-title":"Cells"}],"container-title":["Thrombosis and Haemostasis"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/a-1835-8808.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,9,27]],"date-time":"2022-09-27T00:00:22Z","timestamp":1664236822000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/a-1835-8808"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,4,26]]},"references-count":35,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2022,9,26]]},"published-print":{"date-parts":[[2022,10]]}},"URL":"https:\/\/doi.org\/10.1055\/a-1835-8808","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["0340-6245","2567-689X"],"issn-type":[{"type":"print","value":"0340-6245"},{"type":"electronic","value":"2567-689X"}],"subject":[],"published-other":{"date-parts":[[2022,4,26]]},"published":{"date-parts":[[2022,4,26]]}}}