{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T08:34:18Z","timestamp":1740126858189,"version":"3.37.3"},"reference-count":11,"publisher":"Georg Thieme Verlag KG","issue":"07","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Klin Monbl Augenheilkd"],"published-print":{"date-parts":[[2023,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>This case illustrates clinical, histopathological, immunohistochemical, and molecular pathological diagnostic testing of smoldering myeloma with atypical ophthalmic manifestations. In our\n          case, the choroidal lesion presented as a solitary manifestation of a systemic disease. Choroidal lesions of monoclonal plasma cells are extremely rare and should be included in the\n          differential diagnosis of amelanotic choroidal lesions, even if the histopathological examination of the primary lesion is not informative. Clinical course, immunohistochemistry, and\n          molecular pathology are essential components of the diagnostic pathway.<\/jats:p>","DOI":"10.1055\/a-1838-5027","type":"journal-article","created":{"date-parts":[[2022,7,28]],"date-time":"2022-07-28T22:50:19Z","timestamp":1659048619000},"page":"887-890","source":"Crossref","is-referenced-by-count":0,"title":["Choroidal Manifestation of Smoldering Myeloma: Case Report"],"prefix":"10.1055","volume":"240","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8675-7001","authenticated-orcid":false,"given":"Ekaterina","family":"Sokolenko","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, University Hospital Essen, University of Duisburg-Essen, Essen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patricia","family":"Johansson","sequence":"additional","affiliation":[{"name":"Institute of Cell Biology (Cancer Research), Faculty of Medicine, University of Duisburg-Essen, Essen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Saskia","family":"Ting","sequence":"additional","affiliation":[{"name":"Institute of Pathology, University Hospital Essen, University of Duisburg-Essen, Essen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nikolaos E.","family":"Bechrakis","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, University Hospital Essen, University of Duisburg-Essen, Essen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7868-5167","authenticated-orcid":false,"given":"Miltiadis","family":"Fiorentzis","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, University Hospital Essen, University of Duisburg-Essen, Essen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2022,7,28]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1007\/BF00176888","article-title":"Plasmacytoma of the eye and orbit","volume":"20","author":"J R Adkins","year":"1997","journal-title":"Int Ophthalmol"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"e155","DOI":"10.1111\/aos.12928","article-title":"Bilateral choroidal lesions as first sign of recurrence in multiple myeloma \u2013 histopathological findings and treatment in response to bevacizumab","volume":"95","author":"C Brockmann","year":"2017","journal-title":"Acta Ophthalmol"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1097\/00006982-200312000-00021","article-title":"Presumed malignant plasmacytoma of the choroid as the first manifestation of multiple myeloma","volume":"23","author":"A E Morgan","year":"2003","journal-title":"Retina"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/S0002-9394(00)00706-6","article-title":"Extramedullary plasmacytoma confined to the choroid","volume":"131","author":"S G Honavar","year":"2001","journal-title":"Am J Ophthalmol"},{"key":"ref5","first-page":"27","article-title":"The Diagnosis and Treatment of Multiple Myeloma","volume":"113","author":"C Gerecke","year":"2016","journal-title":"Dtsch Arztebl Int"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"bcr2012006486","DOI":"10.1136\/bcr-2012-006486","article-title":"Ophthalmic manifestations of atypical IgD multiple myeloma","volume":"2012","author":"M R Edmunds","year":"2012","journal-title":"BMJ Case Rep"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1016\/j.optm.2010.10.009","article-title":"Ocular manifestations of multiple myeloma: three cases and a review of the literature","volume":"82","author":"K J Chin","year":"2011","journal-title":"Optometry"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/0039-6257(81)90065-5","article-title":"Ocular manifestations of multiple myeloma, Waldenstr\u00f6m\u02bcs macroglobulinemia and benign monoclonal gammopathy","volume":"26","author":"J Orellana","year":"1981","journal-title":"Surv Ophthalmol"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1177\/2474126419893175","article-title":"Unilateral Multiple Extramedullary Plasmacytoma of the Choroid and Conjunctiva: A Case Report","author":"S Mohamed","year":"2019","journal-title":"J Vitreoret Dis"},{"key":"ref10","first-page":"585","volume-title":"Syndromes and special presentations associated with multiple myeloma","author":"D E Bergsagel","year":"1996","edition":"3rd ed."},{"key":"ref11","doi-asserted-by":"crossref","first-page":"1195","DOI":"10.1007\/s00417-008-0804-9","article-title":"Choroidal plasmacytoma in a patient with multiple myeloma. Diagnosis by fine-needle aspiration biopsy","volume":"246","author":"M Palamar","year":"2008","journal-title":"Graefes Arch Clin Exp Ophthalmol"}],"container-title":["Klinische Monatsbl\u00e4tter f\u00fcr Augenheilkunde"],"original-title":[],"language":"de","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/a-1838-5027.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,5]],"date-time":"2024-11-05T16:25:22Z","timestamp":1730823922000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/a-1838-5027"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,7,28]]},"references-count":11,"journal-issue":{"issue":"07","published-online":{"date-parts":[[2023,7,19]]},"published-print":{"date-parts":[[2023,7]]}},"URL":"https:\/\/doi.org\/10.1055\/a-1838-5027","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["0023-2165","1439-3999"],"issn-type":[{"type":"print","value":"0023-2165"},{"type":"electronic","value":"1439-3999"}],"subject":[],"published":{"date-parts":[[2022,7,28]]}}}