{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T03:32:37Z","timestamp":1788838357384,"version":"build-2803163510"},"reference-count":44,"publisher":"Georg Thieme Verlag KG","issue":"07","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Drug Res (Stuttg)"],"published-print":{"date-parts":[[2022,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n          Background There are studies, which suggest that some diazocine\n                    derivatives can exert effects on the cardiovascular system; however, these\n                    effects are not very clear.<\/jats:p><jats:p>\n          Objective The aim of this research was to evaluate the biological activity\n                    of a diazocine derivative against heart failure translated as area infarct.<\/jats:p><jats:p>\n          Methods Biological activity produced by diazocine derivatives against\n                    heart failure was determinate using an ischemia\/reperfusion injury\n                    model. Besides, to characterize the molecular mechanism of effect exerted by\n                    diazocine derivative on left ventricular pressure (LVP) was determinate in an\n                    isolated rat heart model using nifedipine, PINAME TXA2, and\n                    quinalizarin as controls.<\/jats:p><jats:p>\n          Results The results showed that diazocine derivative decrease the infarct\n                    area and increase the LVP. However, the effect produced by diazocine derivative\n                    on LVP was inhibited in the presence of quinalizarin.<\/jats:p><jats:p>\n          Conclusions The results indicate that biological activity produced by\n                    diazocine derivative on left ventricular pressure is through protein CK2\n                    activation; this phenomenon could be translated as a decrease in both infarct\n                    area and heart failure.<\/jats:p>","DOI":"10.1055\/a-1840-3199","type":"journal-article","created":{"date-parts":[[2022,6,20]],"date-time":"2022-06-20T23:01:12Z","timestamp":1655766072000},"page":"404-411","source":"Crossref","is-referenced-by-count":8,"title":["Evaluation of Biological Activity of a Diazocine Derivative against\n                    Heart Failure Using an Ischemia-Reperfusion Injury Model"],"prefix":"10.1055","volume":"72","author":[{"given":"Figueroa-Valverde","family":"Lauro","sequence":"additional","affiliation":[{"name":"Laboratory of Pharmaco-Chemistry, Faculty of Chemical Biological\n                    Sciences, University Autonomous of Campeche, Campeche,\n                    M\u00e9xico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosas-Nexticapa","family":"Marcela","sequence":"additional","affiliation":[{"name":"Facultad de Nutrici\u00f3n, Universidad Veracruzana, M\u00e9dicos\n                    y Odontologos s\/n, Unidad del Bosque, Veracruz,\n                    M\u00e9xico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L\u00f3pez-Ramos","family":"Maria","sequence":"additional","affiliation":[{"name":"Laboratory of Pharmaco-Chemistry, Faculty of Chemical Biological\n                    Sciences, University Autonomous of Campeche, Campeche,\n                    M\u00e9xico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alvarez-Ramirez","family":"Magdalena","sequence":"additional","affiliation":[{"name":"Facultad de Nutrici\u00f3n, Universidad Veracruzana, M\u00e9dicos\n                    y Odontologos s\/n, Unidad del Bosque, Veracruz,\n                    M\u00e9xico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mateu-Armad Maria","family":"Virginia","sequence":"additional","affiliation":[{"name":"Facultad de Nutrici\u00f3n, Universidad Veracruzana, M\u00e9dicos\n                    y Odontologos s\/n, Unidad del Bosque, Veracruz,\n                    M\u00e9xico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D\u00edaz-Cedillo","family":"Francisco","sequence":"additional","affiliation":[{"name":"Escuela Nacional de Ciencias Biol\u00f3gicas del Instituto\n                    Polit\u00e9cnico Nacional, Santo Tomas, M\u00e9xico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Garcimarrero-Espino","family":"Alejandra","sequence":"additional","affiliation":[{"name":"Facultad de Nutrici\u00f3n, Universidad Veracruzana, M\u00e9dicos\n                    y Odontologos s\/n, Unidad del Bosque, Veracruz,\n                    M\u00e9xico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lopez Gutierrez","family":"Tomas","sequence":"additional","affiliation":[{"name":"Facultad de Nutrici\u00f3n, Universidad Veracruzana, M\u00e9dicos\n                    y Odontologos s\/n, Unidad del Bosque, Veracruz,\n                    M\u00e9xico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melgarejo-Gutierrez","family":"Montserrat","sequence":"additional","affiliation":[{"name":"Facultad de Medicina Universidad Veracruzana, M\u00e9dicos y\n                    Odontologos s\/n, Unidad del Bosque, Veracruz,\n                    M\u00e9xico"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2022,6,20]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"15235","DOI":"10.1039\/D0CC05699E","article-title":"Synthesis of heterocyclic compounds through nucleophilic 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