{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,25]],"date-time":"2025-11-25T16:18:44Z","timestamp":1764087524381,"version":"3.45.0"},"reference-count":46,"publisher":"Georg Thieme Verlag KG","issue":"03","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Tierarztl Prax Ausg K Kleintiere Heimtiere"],"published-print":{"date-parts":[[2022,6]]},"abstract":"<jats:title>Zusammenfassung<\/jats:title>\n                  <jats:p>Gegenstand und Ziel In der Studie soll evaluiert werden, ob die Dunkelfeld-Radiografie (DFR) zur Diagnostik der Gichterkrankung bei V\u00f6geln und Reptilien angewendet werden kann und ob das Tiermodell f\u00fcr die Etablierung des neuen nicht invasiven Verfahrens f\u00fcr die Gichtdiagnostik in der Humanmedizin geeignet ist.<\/jats:p>\n                  <jats:p>Material und Methoden Es wurden insgesamt 18 Gliedma\u00dfen von 11\u2005V\u00f6geln (7 verschiedene Spezies aus den Ordnungen der Papageienv\u00f6gel, Singv\u00f6gel, Greifv\u00f6gel, H\u00fchnerv\u00f6gel und Taubenv\u00f6gel) und 7\u2005Reptilien (4 verschiedene Spezies aus den Ordnungen der Schuppenkriechtiere und Schildkr\u00f6ten) mit und ohne Verdacht auf Gelenksgicht vergleichend an einem gitterbasierten Dunkelfeld-R\u00f6ntgen-Versuchsaufbau sowie mittels konventioneller R\u00f6ntgenuntersuchung gemessen. Jede Bilderfassung erzeugte ein Dunkelfeld- und ein konventionelles Absorptionsr\u00f6ntgenbild. Die Ergebnisse der einzelnen Scans wurden jeweils mit den Ergebnissen einer pathologischen Untersuchung und der Arthrozentese verglichen.<\/jats:p>\n                  <jats:p>Ergebnisse Bei 5 der untersuchten V\u00f6gel und bei 4 der untersuchten Reptilien wurde Gicht pathologisch-anatomisch nachgewiesen. Aus beiden Gruppen konnten bei jeweils 3\u2005Tieren mittels Arthrozentese Harns\u00e4urekristalle in den Gelenken gefunden werden. Im Dunkelfeldbild konnten die Kristalle in jeweils 2\u2005F\u00e4llen detektiert werden. Die nadelf\u00f6rmigen Harns\u00e4urekristalle hatten eine L\u00e4nge von 2,6\u2005\u03bcm bis 56\u2005\u03bcm.<\/jats:p>\n                  <jats:p>Schlussfolgerungen Es konnte gezeigt werden, dass die Harns\u00e4urekristalle ein deutliches Dunkelfeldsignal erzeugen, wohingegen die Kristallablagerungen in den konventionellen R\u00f6ntgenbildern nicht zu sehen waren.<\/jats:p>\n                  <jats:p>Klinische Relevanz Die gewonnenen Ergebnisse zeigen, dass am Tiermodell von V\u00f6geln und Reptilien eine Harns\u00e4urekristalldetektion mittels nicht invasiver bildgebender Dunkelfeld Bildgebung m\u00f6glich ist. Dies k\u00f6nnte die Gichtdiagnostik nicht nur in der Tiermedizin, sondern auch in der Humanmedizin erweitern und die Arthrozentese bei positivem DFR Befund abl\u00f6sen. Pr\u00e4klinische Scanner, welche den Dunkelfeld- und Phasenkontrast nutzen, existieren bereits f\u00fcr H\u00e4nde und Mammografie und werden im Humanbereich bereits klinisch erprobt.<\/jats:p>","DOI":"10.1055\/a-1843-7736","type":"journal-article","created":{"date-parts":[[2022,7,5]],"date-time":"2022-07-05T18:32:14Z","timestamp":1657045934000},"page":"185-196","source":"Crossref","is-referenced-by-count":0,"title":["Die Dunkelfeld-Radiografie \u2013 ein neuer Weg zur Diagnostik von Gichterkrankungen bei V\u00f6geln und Reptilien?"],"prefix":"10.1055","volume":"50","author":[{"given":"Nathalie","family":"Roiser","sequence":"additional","affiliation":[{"name":"Zentrum f\u00fcr klinische Tiermedizin, Klinik f\u00fcr V\u00f6gel, Kleins\u00e4uger, Reptilien und Zierfische, Tier\u00e4rztliche Fakult\u00e4t der Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Josef","family":"Scholz","sequence":"additional","affiliation":[{"name":"Lehrstuhl f\u00fcr Biomedizinische Physik, Fakult\u00e4t f\u00fcr Physik und Munich School of BioEngineering, Technische Universit\u00e4t M\u00fcnchen"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Melanie A.","family":"Kimm","sequence":"additional","affiliation":[{"name":"Institut f\u00fcr diagnostische und interventionelle Radiologie, Technische Universit\u00e4t M\u00fcnchen, Klinikum rechts der Isar"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jana","family":"Andrejewski","sequence":"additional","affiliation":[{"name":"Lehrstuhl f\u00fcr Biomedizinische Physik, Fakult\u00e4t f\u00fcr Physik und Munich School of BioEngineering, Technische Universit\u00e4t M\u00fcnchen"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christine","family":"Baumgartner","sequence":"additional","affiliation":[{"name":"Zentrum f\u00fcr pr\u00e4klinische Forschung, Technische Universit\u00e4t M\u00fcnchen"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eva","family":"Braig","sequence":"additional","affiliation":[{"name":"Lehrstuhl f\u00fcr Biomedizinische Physik, Fakult\u00e4t f\u00fcr Physik und Munich School of BioEngineering, Technische Universit\u00e4t M\u00fcnchen"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julia","family":"Herzen","sequence":"additional","affiliation":[{"name":"Lehrstuhl f\u00fcr Biomedizinische Physik, Fakult\u00e4t f\u00fcr Physik und Munich School of BioEngineering, Technische Universit\u00e4t M\u00fcnchen"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniela","family":"Pfeiffer","sequence":"additional","affiliation":[{"name":"Institut f\u00fcr diagnostische und interventionelle Radiologie, Technische Universit\u00e4t M\u00fcnchen, Klinikum rechts der Isar"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R\u00fcdiger","family":"Korbel","sequence":"additional","affiliation":[{"name":"Zentrum f\u00fcr klinische Tiermedizin, Klinik f\u00fcr V\u00f6gel, Kleins\u00e4uger, Reptilien und Zierfische, Tier\u00e4rztliche Fakult\u00e4t der Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2022,7,5]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"649","DOI":"10.1038\/nrrheum.2015.91","article-title":"Global epidemiology of gout: prevalence, incidence and risk factors. 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