{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,24]],"date-time":"2026-01-24T14:23:16Z","timestamp":1769264596433,"version":"3.49.0"},"reference-count":35,"publisher":"Georg Thieme Verlag KG","issue":"12","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Endoscopy"],"published-print":{"date-parts":[[2022,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n          Background\u2002The risk of advanced pathology increases with polyp size, as does the potential for mismanagement when optical diagnosis is used. This study aimed to evaluate the proportion of patients who would be assigned inadequate surveillance intervals when different size cutoffs are adopted for use of optical diagnosis.<\/jats:p><jats:p>\n          Methods\u2002In a post hoc analysis of three prospective studies, the use of optical diagnosis was evaluated for three polyp size groups: 1\u20133, 1\u20135, and 1\u201310\u200amm. The primary outcome was the proportion of patients in whom advanced adenomas were found and optical diagnosis resulted in delayed surveillance. Secondary outcomes included agreements between surveillance intervals based on high confidence optical diagnosis and pathology outcomes, reduction in histopathological examinations, and proportion of patients who could receive an immediate surveillance recommendation.<\/jats:p><jats:p>\n          Results\u2002We included 3374 patients (7291 polyps \u2264\u200a10\u200amm) undergoing complete colonoscopies (median age 66.0 years, 75.2\u200a% male, 29.6\u200a% for screening). The percentage of patients with advanced adenomas and either 2- or 7-year delayed surveillance intervals (n\u200a=\u200a79) was 3.8\u200a%, 15.2\u200a%, and 25.3\u200a% for size cutoffs of 1\u20133, 1\u20135, and 1\u201310\u200amm polyps, respectively (P\u200a&lt;\u200a0.001). Surveillance interval agreements between pathology and optical diagnosis for the three groups were 97.2\u200a%, 95.5\u200a%, and 94.2\u200a%, respectively. Total reductions in pathology examinations for the three groups were 33.5\u200a%, 62.3\u200a%, and 78.2\u200a%, respectively.<\/jats:p><jats:p>\n          Conclusion\u2002A 3-mm cutoff for clinical implementation of optical diagnosis resulted in a very low risk of delayed management of advanced neoplasia while showing high surveillance interval agreement with pathology and a one-third reduction in overall requirement for pathology examinations.<\/jats:p>","DOI":"10.1055\/a-1843-9535","type":"journal-article","created":{"date-parts":[[2022,6,3]],"date-time":"2022-06-03T23:06:35Z","timestamp":1654297595000},"page":"1182-1190","source":"Crossref","is-referenced-by-count":6,"title":["What size cutoff level should be used to implement optical polyp diagnosis?"],"prefix":"10.1055","volume":"54","author":[{"given":"Mahsa","family":"Taghiakbari","sequence":"additional","affiliation":[{"name":"University of Montreal, Montreal, Quebec, Canada"},{"name":"University of Montreal Hospital Research Center (CRCHUM), Montreal, Quebec, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heiko","family":"Pohl","sequence":"additional","affiliation":[{"name":"Dartmouth Geisel School of Medicine, Hanover, New Hampshire, United States"},{"name":"VA Medical Center, Whiter River Junction, Vermont, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0649-0691","authenticated-orcid":false,"given":"Roupen","family":"Djinbachian","sequence":"additional","affiliation":[{"name":"University of Montreal Hospital Research Center (CRCHUM), Montreal, Quebec, Canada"},{"name":"Division of Internal Medicine, University of Montreal Hospital Center (CHUM), Montreal, Quebec, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joseph C.","family":"Anderson","sequence":"additional","affiliation":[{"name":"Dartmouth Geisel School of Medicine, Hanover, New Hampshire, United States"},{"name":"VA Medical Center, Whiter River Junction, Vermont, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Danny","family":"Metellus","sequence":"additional","affiliation":[{"name":"University of Montreal Hospital Research Center (CRCHUM), Montreal, Quebec, Canada"},{"name":"Division of Internal Medicine, University of Montreal Hospital Center (CHUM), Montreal, Quebec, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alan N.","family":"Barkun","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, McGill University Health Center, McGill University, Montreal, Quebec, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mickael","family":"Bouin","sequence":"additional","affiliation":[{"name":"University of Montreal Hospital Research Center (CRCHUM), Montreal, Quebec, Canada"},{"name":"Division of Gastroenterology, University of Montreal Hospital Center (CHUM), Montreal, Quebec, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6125-0068","authenticated-orcid":false,"given":"Daniel","family":"von Renteln","sequence":"additional","affiliation":[{"name":"University of Montreal Hospital Research Center (CRCHUM), Montreal, Quebec, Canada"},{"name":"Division of Gastroenterology, University of Montreal Hospital Center (CHUM), Montreal, Quebec, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2022,6,3]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"1022","DOI":"10.1016\/j.gie.2012.01.020","article-title":"Prevalence of advanced histological features in diminutive and small colon polyps","volume":"75","author":"N Gupta","year":"2012","journal-title":"Gastrointest Endosc"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"1100","DOI":"10.1053\/j.gastro.2008.06.083","article-title":"Polyp size and advanced histology in 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Dig"}],"container-title":["Endoscopy"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/a-1843-9535.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,11,30]],"date-time":"2022-11-30T02:49:34Z","timestamp":1669776574000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/a-1843-9535"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,6,3]]},"references-count":35,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2022,11,29]]},"published-print":{"date-parts":[[2022,12]]}},"URL":"https:\/\/doi.org\/10.1055\/a-1843-9535","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["0013-726X","1438-8812"],"issn-type":[{"value":"0013-726X","type":"print"},{"value":"1438-8812","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,6,3]]}}}