{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T08:34:43Z","timestamp":1740126883512,"version":"3.37.3"},"reference-count":19,"publisher":"Georg Thieme Verlag KG","issue":"05","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Z Geburtshilfe Neonatol"],"published-print":{"date-parts":[[2022,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n          Objective In our study, we aimed to examine the effect of therapeutic\n                    hypothermia treatment on C-reactive protein (CRP) and interleukin-6 (IL-6) in\n                    infants with hypoxic ischemic encephalopathy (HIE).<\/jats:p><jats:p>\n          Methods The data of the patients with the diagnosis of HIE we followed up\n                    in our unit between 2017 and 2018 were analyzed retrospectively. Patients who\n                    died during follow-up and patients with proven septicemia at the time of\n                    examination were excluded from the study. The routine CRP and IL-6 values\n                    \u200b\u200bof the patients included in the study were compared before and\n                    after hypothermia treatment.<\/jats:p><jats:p>\n          Results Therapeutic hypothermia treatment applied for 72\u2009hours was\n                    found to cause a statistically significant increase in CRP after treatment when\n                    compared with the values \u200b\u200bmeasured before treatment (0.6\n                    (0.2\u20131.9) before and median (P25\u201375), and after treatment 7.5\n                    (4\u201318) and median (P25\u201375) mg\/L, p=0.00). While\n                    IL-6 was found to be high in the early period due to the effect of hypoxia, it\n                    was found to be low after hypothermia treatment (80.5 (40\u2013200) median\n                    (P25\u201375) \u2013 32 (18\u201350) median (P25\u201375)\n                    pg\/ml, p=0.131). While the white blood cell count was high\n                    before hypothermia treatment due to hypoxia, it was found to be low after\n                    treatment (24600 (19600\u201330100) median (P25\u201375) \u201311300\n                    (8800\u201314200) median (P25\u201375)\/\u00b5L,\n                    p=0.001).<\/jats:p><jats:p>\n          Conclusion White blood cells and IL-6 can be found to be high due to\n                    hypoxia without infection, and CRP can be found to be high after therapeutic\n                    hypothermia treatment without infection. The effect of hypoxia and hypothermia\n                    should be considered when evaluating acute phase reactants.<\/jats:p>","DOI":"10.1055\/a-1846-1545","type":"journal-article","created":{"date-parts":[[2022,8,22]],"date-time":"2022-08-22T23:03:15Z","timestamp":1661209395000},"page":"319-324","source":"Crossref","is-referenced-by-count":0,"title":["Effect of Therapeutic Hypothermia Treatment on Acute Phase\n                    Reactants"],"prefix":"10.1055","volume":"226","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2113-5591","authenticated-orcid":false,"given":"Sarkhan","family":"Elbayiyev","sequence":"additional","affiliation":[{"name":"Division of Neonatology, Ankara City Hospital, University of Health\n                    Sciences, Ankara, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4831-8950","authenticated-orcid":false,"given":"G\u00fcls\u00fcm Kad\u0131o\u011flu","family":"\u015eim\u015fek","sequence":"additional","affiliation":[{"name":"Division of Neonatology, Ankara City Hospital, University of Health\n                    Sciences, Ankara, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7846-7634","authenticated-orcid":false,"given":"\u00d6mer","family":"Ertekin","sequence":"additional","affiliation":[{"name":"Division of Neonatology, Ankara City Hospital, University of Health\n                    Sciences, Ankara, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2999-059X","authenticated-orcid":false,"given":"\u015eehribanu","family":"I\u015f\u0131k","sequence":"additional","affiliation":[{"name":"Division of Neonatology, Ankara City Hospital, University of Health\n                    Sciences, Ankara, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3177-9411","authenticated-orcid":false,"given":"Hayriye G\u00f6zde","family":"Kanmaz Kutman","sequence":"additional","affiliation":[{"name":"Division of Neonatology, Ankara City Hospital, University of Health\n                    Sciences, Ankara, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9307-3003","authenticated-orcid":false,"given":"Fuat Emre","family":"Canpolat","sequence":"additional","affiliation":[{"name":"Division of Neonatology, Ankara City Hospital, University of Health\n                    Sciences, Ankara, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2022,8,22]]},"reference":[{"key":"ref1","first-page":"Cd003311","article-title":"Cooling for newborns with hypoxic ischemic encephalopathy","volume":"2013","author":"S E 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Perinatol"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"1401","DOI":"10.1055\/s-0036-1583192","article-title":"Temporal relationship between serum levels of interleukin-6 and C-reactive\n                    protein in therapeutic hypothermia for neonatal hypoxic-ischemic\n                    encephalopathy","volume":"33","author":"J Saito","year":"2016","journal-title":"Am J Perinatol"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1016\/j.pediatrneurol.2010.05.009","article-title":"Whole body hypothermia and oxidative stress in babies with hypoxic-ischemic\n                    brain injury","volume":"43","author":"S Perrone","year":"2010","journal-title":"Pediatr Neurol"},{"key":"ref13","first-page":"667","article-title":"Effect of therapeutic hypothermia on C-reactive protein levels in patients with\n                    perinatal asphyxia","volume":"32","author":"N Okumu\u015f","year":"2015","journal-title":"Am J Perinatol"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"F458","DOI":"10.1136\/archdischild-2013-305763","article-title":"Therapeutic hypothermia delays the C-reactive protein response and suppresses\n                    white blood cell and platelet count in infants with neonatal encephalopathy","volume":"99","author":"E Chakkarapani","year":"2014","journal-title":"Arch Dis Child Fetal Neonatal Ed"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"1016","DOI":"10.1093\/clinchem\/47.6.1016","article-title":"Serial measurements of C-reactive protein and interleukin-6 in the immediate\n                    postnatal period: reference intervals and analysis of maternal and perinatal\n                    confounders","volume":"47","author":"C Chiesa","year":"2001","journal-title":"Clin Chem"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"F163","DOI":"10.1136\/archdischild-2016-312506","article-title":"C-reactive protein in healthy term newborns during the first 48 hours of\n                    life","volume":"103","author":"S Perrone","year":"2018","journal-title":"Arch Dis Child Fetal Neonatal Ed"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"786","DOI":"10.1097\/PCC.0b013e3182975cc9","article-title":"Altered circulating leukocytes and their chemokines in a clinical trial of\n                    therapeutic hypothermia for neonatal hypoxic ischemic\n                    encephalopathy\u2009*","volume":"14","author":"D D Jenkins","year":"2013","journal-title":"Pediatr Crit Care Med"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"e759","DOI":"10.1097\/MPH.0000000000001648","article-title":"Therapeutic hypothermia and leukocytosis in newborns: an unusual\n                    association","volume":"42","author":"D U De Rose","year":"2020","journal-title":"J Pediatr Hematol Oncol"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1159\/000329818","article-title":"Effect of therapeutic hypothermia in neonates with hypoxic-ischemic\n                    encephalopathy on platelet function","volume":"101","author":"R D Christensen","year":"2012","journal-title":"Neonatology"}],"container-title":["Zeitschrift f\u00fcr Geburtshilfe und Neonatologie"],"original-title":[],"language":"de","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/a-1846-1545.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,10,13]],"date-time":"2022-10-13T23:18:35Z","timestamp":1665703115000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/a-1846-1545"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,8,22]]},"references-count":19,"journal-issue":{"issue":"05","published-online":{"date-parts":[[2022,10,13]]},"published-print":{"date-parts":[[2022,10]]}},"URL":"https:\/\/doi.org\/10.1055\/a-1846-1545","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["0948-2393","1439-1651"],"issn-type":[{"type":"print","value":"0948-2393"},{"type":"electronic","value":"1439-1651"}],"subject":[],"published":{"date-parts":[[2022,8,22]]}}}