{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T02:41:39Z","timestamp":1784256099275,"version":"3.55.0"},"reference-count":36,"publisher":"Georg Thieme Verlag KG","issue":"07","funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["81970678"],"award-info":[{"award-number":["81970678"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Horm Metab Res"],"published-print":{"date-parts":[[2022,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The aim of the work was to investigate the bone mineral density (BMD) in\n                    middle-aged male patients with both childhood-onset (CO) and adulthood-onset\n                    (AO) adult growth hormone deficiency (AGHD). In this retrospective\n                    cross-sectional study in a major medical center in China, dual X-ray\n                    absorptiometry was performed in 50 male AGHD patients (average age was\n                    35.2\u00b19.8 years) and 50 age- and BMI-matched non-athletic healthy men.\n                    BMD was compared between AGHD patients and controls. Compared with healthy\n                    controls, AGHD group had significantly decreased IGF-1 (p1&lt;0.001) and\n                    IGF-1 SDS (p1&lt;0.001). Serum testosterone levels were significantly lower\n                    in AGHD patients (p1&lt;0.001), mainly in AO AGHD patients\n                    (p3&lt;0.001). The BMD of the femoral neck, trochanter, femoral shaft,\n                    total hip, and lumbar spine were significantly lower in all AGHD patients\n                    compared with healthy controls (all p1&lt;0.05), especially in CO AGHD\n                    patients (all p2&lt;0.05). Multiple stepwise linear regression indicated\n                    AGHD was negatively correlated with BMD at each site (\u03b2&lt;0,\n                    p&lt;0.05). Additionally, serum testosterone level was an independent\n                    influencing factor of BMD of the femoral neck (\u03b2=0.256,\n                    p=0.018) and lumbar spine (\u03b2=0.219, p=0.040).\n                    BMD was significantly reduced in AGHD patients, especially in CO AGHD patients.\n                    Our data suggested that the status of growth hormone deficiency and testosterone\n                    level were important for maintaining of bone mineral density in middle-aged male\n                    patients with AGHD.<\/jats:p>","DOI":"10.1055\/a-1850-7461","type":"journal-article","created":{"date-parts":[[2022,5,12]],"date-time":"2022-05-12T22:43:20Z","timestamp":1652395400000},"page":"450-457","source":"Crossref","is-referenced-by-count":3,"title":["Reduced Bone Mineral Density in Middle-Aged Male Patients with Adult\n                    Growth Hormone Deficiency"],"prefix":"10.1055","volume":"54","author":[{"given":"Shanshan","family":"Liu","sequence":"additional","affiliation":[{"name":"Endocrinology, Peking Union Medical College Hospital, Dongcheng-qu,\n                    China"},{"name":"Graduate School, Hebei North University, Zhangjiakou,\n                    China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongbo","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Peking Union Medical College Hospital,\n                    Dongcheng-qu, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanyuan","family":"Xu","sequence":"additional","affiliation":[{"name":"Endocrinology, Peking Union Medical College Hospital, Beijing,\n                    China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhibo","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Peking Union Medical College Hospital,\n                    Dongcheng-qu, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xi","family":"Bai","sequence":"additional","affiliation":[{"name":"Endocrinology, Peking Union Medical College Hospital Department of\n                    Endocrinology, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linjie","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Peking Union Medical College Hospital,\n                    Dongcheng-qu, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lian","family":"Duan","sequence":"additional","affiliation":[{"name":"Endocrinology, Peking Union Medical College Hospital, Beijing,\n                    China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fengying","family":"Gong","sequence":"additional","affiliation":[{"name":"Endocrinology, Peking Union Medical College Hospital, Dongcheng-qu,\n                    China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huijuan","family":"Zhu","sequence":"additional","affiliation":[{"name":"Endocrinology Dept., Peking Union Medical College Hospital,\n                    Dongcheng-qu, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Pan","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Peking Union Medical College Hospital,\n                    Dongcheng-qu, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2022,7,14]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"1191","DOI":"10.4158\/GL-2019-0405","article-title":"American association of clinical endocrinologists and American college of\n                    endocrinology guidelines for management of growth hormone deficiency in adults\n                    and patients transitioning from pediatric to adult care","volume":"25","author":"KC J Yuen","year":"2019","journal-title":"Endocr Pract"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1530\/eje.1.02191","article-title":"Incidence of GH deficiency - 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