{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T07:51:27Z","timestamp":1769586687734,"version":"3.49.0"},"reference-count":24,"publisher":"Georg Thieme Verlag KG","issue":"06","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dtsch Med Wochenschr"],"published-print":{"date-parts":[[2023,3]]},"abstract":"<jats:title>Was ist neu?<\/jats:title><jats:p>\n          Periprothetische Infektionen: Diagnostik, Prothesenerhalt und\n        Therapiel\u00e4nge. Nach einer neuen Studie kann bei Vorliegen einer h\u00e4matogenen\n      periprothetischen Infektion und weiteren einliegenden Gelenkprothesen, die in der klinischen\n      Untersuchung unauff\u00e4llig sind, auf weitere invasive oder bildgebende Diagnostik verzichtet\n      werden. Periprothetische Infektionen, die sp\u00e4t auftreten (&gt; 3 Monate nach Implantation)\n      haben ein schlechteres Outcome. Neue Studien versuchen Faktoren zu identifizieren, wann der\n      Prothesenerhalt weiterhin eine Option ist. Eine neue randomisierte Landmarkstudie aus\n      Frankreich konnte keine Nichtunterlegenheit f\u00fcr 6 versus 12 Wochen Therapiel\u00e4nge zeigen. Somit\n      ist anzunehmen, dass dies aktuell der Standard f\u00fcr alle OP-Modalit\u00e4ten (Erhalt oder Wechsel)\n      wird. W\u00fcnschenswert w\u00e4ren weitere Studien zu dem Thema, die v.a. mehr Patienten mit sp\u00e4tem\n      Prothesenwechsel betrachten.<\/jats:p><jats:p>\n          Spondylodiszitis: Inzidenz und Erregerprofil. Die\n      Spondylodiszitis ist eine eher seltene Knocheninfektion, deren Inzidenz in den vergangenen\n      Jahren aber weiter stark gestiegen ist (erneut fast verdoppelt in 10 Jahren). Betroffen sind\n      weiterhin vor allem \u00e4ltere Personen, M\u00e4nner und komorbide Patienten. Eine retrospektive Studie\n      aus Korea von Kim et al. gibt Aufschluss \u00fcber die Erregerverteilung in verschiedenen\n      Altersgruppen sowie mit verschiedenen Komorbidit\u00e4ten. Damit hilft sie bei der Einsch\u00e4tzung des\n      verursachenden Erregers und der Auswahl der empirischen Therapie, wenn die\n      Erregeridentifizierung vor Therapiestart nicht gelingt. S. aureus ist am h\u00e4ufigsten \u00fcber alle\n      Altersgruppen, aber mit Zunahme von Enterokokken und v.a. gram-negativen Erregern bei\n      \u00c4lteren.<\/jats:p><jats:p>\n          Diabetische Fu\u00dfinfektion: Leitlinien, Diagnostik und Therapiel\u00e4nge.\n      Die Leitlinien der \u201eInternational Working Group on the Diabetic Foot\u201c (IWGDF) wurden\n      mit leicht ver\u00e4nderter Klassifikation aktualisiert, au\u00dferdem hat die Deutsche Diabetes\n      Gesellschaft neue Handlungsempfehlungen publiziert. Die empirische Therapie richtet sich\n      weiterhin nach der Schwere der Infektion und weiteren Risikofaktoren (wie Vortherapien,\n      Isch\u00e4mie). Die mikrobiologische Diagnostik aus Gewebeproben wird gegen\u00fcber Abstrichen als\n      \u00fcberlegen beschrieben. Nach einer randomisierten Pilotstudie scheinen 3 Wochen Therapiedauer\n      bei Osteomyelitis nach Debridement 6 Wochen nicht unterlegen zu sein. Gr\u00f6\u00dfere randomisierte\n      Studien zu dem Thema rekrutieren aktuell.<\/jats:p>","DOI":"10.1055\/a-1853-4777","type":"journal-article","created":{"date-parts":[[2023,3,6]],"date-time":"2023-03-06T23:32:46Z","timestamp":1678145566000},"page":"313-317","source":"Crossref","is-referenced-by-count":2,"title":["Update Knocheninfektionen"],"prefix":"10.1055","volume":"148","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6711-6516","authenticated-orcid":false,"given":"Charlotte","family":"Meyer-Schwickerath","sequence":"additional","affiliation":[{"name":"Klinik I f\u00fcr Innere Medizin, Universit\u00e4t zu K\u00f6ln, Medizinische Fakult\u00e4t und Uniklinik K\u00f6ln, K\u00f6ln"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2048-7296","authenticated-orcid":false,"given":"Dorothee","family":"Jochimsen","sequence":"additional","affiliation":[{"name":"Klinik I f\u00fcr Innere Medizin, Universit\u00e4t zu K\u00f6ln, Medizinische 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