{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,9,30]],"date-time":"2022-09-30T05:02:52Z","timestamp":1664514172226},"reference-count":9,"publisher":"Georg Thieme Verlag KG","issue":"10","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Laryngorhinootologie"],"published-print":{"date-parts":[[2022,10]]},"abstract":"<jats:title>Zusammenfassung<\/jats:title><jats:p>Anaphylaktische Reaktionen nach Impfungen sind selten. Zwei F\u00e4lle von Reaktionen nach der Pfizer-BioNTech-Covid-19-Vakzine, BNT162b2, wurden aus dem UK berichtet, weitere 19 aus den USA. Als m\u00f6glicher Ausl\u00f6ser wurde Polyethylenglycol (PEG) angeschuldigt. Pegylierung ist ein \u00fcblicher Vorgang in der Impfstoffherstellung, um die Substanzen vor schnellem immunologischem Abbau zu sch\u00fctzen. PEG ist ein Polyether (Synonyme z. B. Laureth-9, Polidocanol, Thesit, Macrogol) und findet sich in Kosmetika, K\u00f6rperpflegeprodukten, Nahrungsmitteln, Liposomen und Nanopartikeln als Drug-Delivery-Systeme f\u00fcr Medikamente und als osmotisches Laxans vor Gastro-\/Koloskopien. IgM-Antik\u00f6rper auf PEG werden bei 70% der Bev\u00f6lkerung nachgewiesen. Bei 2 F\u00e4llen von Soforttyp-Reaktionen auf PEG fanden sich IgE-Antik\u00f6per, bei anderen Medikamentengaben mit PEG geht man von pseudoallergischen Reaktionen \u00fcber die Komplement-Aktivierungs-related Pseudoallergie (CARPA) aus. In Relation zum weit verbreiteten Einsatz von PEG sind die Impfreaktionen sehr selten und aktuell kein Grund, Allergiker oder Menschen mit Anaphylaxien bei entsprechenden Vorsichtsma\u00dfnahmen auf bekannte Ausl\u00f6ser auszuschlie\u00dfen. Aufgrund der Meldepflicht (Gesundheitsamt und Arzneimittelkommission der deutschen \u00c4rzteschaft) ist bald mit weiteren Erkenntnissen zu rechnen.<\/jats:p>","DOI":"10.1055\/a-1861-7047","type":"journal-article","created":{"date-parts":[[2022,9,29]],"date-time":"2022-09-29T22:41:41Z","timestamp":1664491301000},"page":"784-786","source":"Crossref","is-referenced-by-count":0,"title":["Polyethylenglycol \u2013 Freund oder Feind?"],"prefix":"10.1055","volume":"101","author":[{"given":"Christiane","family":"Bayerl","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Dermatologie und Allergologie, Hauttumorzentrum Wiesbaden, Helios Dr. Horst Schmidt Kliniken Wiesbaden, Wiesbaden, Deutschland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthias","family":"Herbst","sequence":"additional","affiliation":[{"name":"Haut\u00e4rzte im Merckhaus, Darmstadt"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2022,9,29]]},"reference":[{"key":"ref2","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1007\/s15012-019-3186-2","article-title":"Ein Mythos wird entmystifiziert","volume":"35","author":"T Ankermann","year":"2019","journal-title":"Hautnah dermatol"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"50","DOI":"10.7774\/cevr.2014.3.1.50","article-title":"Vaccine allergies","volume":"3","author":"EH Chung","year":"2014","journal-title":"Clin Exp Vaccine Res"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1186\/s13223-016-0172-7","article-title":"Polyethylene gylcol as a cause of anaphylaxis","volume":"12","author":"K Wylon","year":"2016","journal-title":"Allergy Asthma Clin Immunol"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"1533","DOI":"10.1016\/j.jaip.2018.12.003","article-title":"Immediate hypersensitivity to polyethylene gylcols and polysorbates: more common than we have recognized","volume":"7","author":"CB Stone","year":"2019","journal-title":"J Allergy Clin Immunol Pract"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"531","DOI":"10.1111\/ped.12131","article-title":"Anaphylactic reaction to polyethylene \u2013 glycol conjugated \u2013 asparaginase: Premedication and desensitization may not be sufficient","volume":"55","author":"EM Sahiner","year":"2013","journal-title":"Pediatr Int"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1186\/s13223-019-0327-4","article-title":"Immediate hypersensitivity to polyethylene glycols in unrelated products: when standardization in the nomeclature of the components of drugs, cosmetics, and food becomes necessary","volume":"15","author":"VJ Cerda","year":"2019","journal-title":"Allergy Asthma Clin Immunol"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1016\/j.addr.2020.07.024","article-title":"Anit-PEG antibodies; properties, formation, testing and role in advers immune reactions to PEGylated nano-biopharmaceuticals","volume":"154\u2013155","author":"G Kozma","year":"2020","journal-title":"Adv Drug Deliv Rev"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"222","DOI":"10.3389\/fimmu.2020.00222","article-title":"Engineered nanomatarials and type I allergic hypersensitivity reactions","volume":"11","author":"NB Alsaleh","year":"2020","journal-title":"Front Immunol"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"100472","DOI":"10.1016\/j.waojou.2020.100472","article-title":"Position Paper","volume":"13","author":"V Corodona","year":"2020","journal-title":"Wold allergy organization anaphylaxis guidance"}],"container-title":["Laryngo-Rhino-Otologie"],"original-title":[],"language":"de","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/a-1861-7047.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,9,29]],"date-time":"2022-09-29T22:41:55Z","timestamp":1664491315000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/a-1861-7047"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,9,29]]},"references-count":9,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2022,9,29]]},"published-print":{"date-parts":[[2022,10]]}},"URL":"https:\/\/doi.org\/10.1055\/a-1861-7047","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["0935-8943","1438-8685"],"issn-type":[{"value":"0935-8943","type":"print"},{"value":"1438-8685","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,9,29]]}}}