{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,24]],"date-time":"2026-01-24T03:52:53Z","timestamp":1769226773616,"version":"3.49.0"},"reference-count":55,"publisher":"Georg Thieme Verlag KG","issue":"04","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Laryngorhinootologie"],"published-print":{"date-parts":[[2023,4]]},"abstract":"<jats:title>Zusammenfassung<\/jats:title><jats:p>Eine Beteiligung des \u00d6sophagus bei der Hauterkrankung Lichen planus wurde erstmals 1982 beschrieben und fast 30 Jahre lang als eine Rarit\u00e4t angesehen. Untersuchungen der letzten 10 Jahre aber zeigen, dass diese Erkrankung weniger selten ist als angenommen. Es ist sogar anzunehmen, dass der \u00f6sophageale Lichen planus (Esophageal Lichen planus, ELP) h\u00e4ufiger ist als die Eosinophile \u00d6sophagitis (EoE). Die \u00d6sophagusbeteiligung betrifft meist Frauen im mittleren Alter. Das Hauptsymptom ist eine Dysphagie. Endoskopisch erkennt man in der Speiser\u00f6hre eine charakteristische Schleimhautabl\u00f6sung, eine Trachealisierung, und gelegentlich Hyperkeratosen und bei langem Bestehen auch Stenosen. Wegweisend ist die Histologie mit einer subepithelialen Abl\u00f6sung sowie einem bandf\u00f6rmigen Infiltrat aus T-Lymphozyten, dem Nachweis von apoptotischen Keratinozyten (Civatte Bodies) und Dyskeratosen. Die direkte Immunfluoreszenz zeigt Fibrinogen-Ablagerungen entlang der Basalmembran. Eine etablierte Therapie gibt es bisher nicht. Die Behandlung mit topischen Steroiden ist in 2\/3 der F\u00e4lle wirksam. Eine Therapie wie beim klassischen Lichen planus scheint unwirksam zu sein. Bei symptomatischen Stenosen kann eine Dilatation indiziert sein. Der ELP reiht sich in die Gruppe der \u201eneuen\u201c immunologisch vermittelten Erkrankungen des \u00d6sophagus ein.<\/jats:p>","DOI":"10.1055\/a-1861-7187","type":"journal-article","created":{"date-parts":[[2023,4,11]],"date-time":"2023-04-11T22:30:30Z","timestamp":1681252230000},"page":"272-281","source":"Crossref","is-referenced-by-count":2,"title":["Der Lichen planus des \u00d6sophagus \u2013 Eine untersch\u00e4tzte Erkrankung"],"prefix":"10.1055","volume":"102","author":[{"given":"Carmen","family":"Monasterio","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Innere Medizin II, Universit\u00e4tsklinikum Freiburg, Medizinische Fakult\u00e4t, Albert-Ludwigs-Universit\u00e4t Freiburg, 79106 Freiburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Annegrit","family":"Decker","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Innere Medizin II, Universit\u00e4tsklinikum Freiburg, Medizinische Fakult\u00e4t, 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