{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T17:01:50Z","timestamp":1793034110869,"version":"4.5.0"},"reference-count":113,"publisher":"Georg Thieme Verlag KG","issue":"03","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Semin Liver Dis"],"published-print":{"date-parts":[[2022,8]]},"abstract":"<jats:p>The map and global disease burden of chronic liver diseases are markedly changing, with nonalcoholic fatty liver disease (NAFLD) becoming the most common cause of liver diseases coinciding with the current epidemics of obesity, type 2 diabetes, and metabolic syndrome. Understanding the incidence and prevalence of NAFLD is critical because of its linkage to a significant economic burden of hospitalization and changing patterns in consequences, such as liver transplantation. Moreover, the long-term average health care expenses of NAFLD patients have exceeded those of other liver diseases. To lessen the imminent burden of NAFLD, immediate actions to raise worldwide awareness and address metabolic risk factors are required. This review summarizes key data about the global disease burden of NAFLD, modifiable and nonmodifiable risk factors, and current preventive approaches.<\/jats:p>","DOI":"10.1055\/a-1862-9088","type":"journal-article","created":{"date-parts":[[2022,5,26]],"date-time":"2022-05-26T22:39:30Z","timestamp":1653604770000},"page":"401-412","source":"Crossref","is-referenced-by-count":60,"title":["Nonalcoholic Fatty Liver Disease: Current Global Burden"],"prefix":"10.1055","volume":"42","author":[{"given":"Mohamed","family":"El-Kassas","sequence":"additional","affiliation":[{"name":"Endemic Medicine Department, Faculty of Medicine, Helwan University, Cairo, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joaqu\u00edn","family":"Cabezas","sequence":"additional","affiliation":[{"name":"Gastroenterology and Hepatology Department, University Hospital Marques de Valdecilla, Santander, Spain"},{"name":"Department of Gastroenterology and Hepatology, Research Institute Valdecilla (IDIVAL), Santander, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paula Iruzubieta","family":"Coz","sequence":"additional","affiliation":[{"name":"Gastroenterology and Hepatology Department, University Hospital Marques de Valdecilla, Santander, Spain"},{"name":"Department of Gastroenterology and Hepatology, Research Institute Valdecilla (IDIVAL), Santander, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming-Hua","family":"Zheng","sequence":"additional","affiliation":[{"name":"NAFLD Research Center, Department of Hepatology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China"},{"name":"Key Laboratory of Diagnosis and Treatment for the Development of Chronic Liver Disease in Zhejiang Province, Wenzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan Pablo","family":"Arab","sequence":"additional","affiliation":[{"name":"Departamento de Gastroenterolog\u00eda, Escuela de Medicina, Pontificia Universidad Cat\u00f3lica de Chile, Santiago, Chile"},{"name":"Division of Gastroenterology, Department of Medicine, Schulich School of Medicine, Western University & London Health Sciences Centre, London, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abeer","family":"Awad","sequence":"additional","affiliation":[{"name":"Internal Medicine Department, Faculty of Medicine, Cairo University, Cairo, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2022,8,24]]},"reference":[{"issue":"10","key":"ref1","doi-asserted-by":"crossref","first-page":"1103","DOI":"10.1097\/MEG.0000000000001235","article-title":"Nonalcoholic fatty liver disease: current concepts, epidemiology and management strategies","volume":"30","author":"D Tomic","year":"2018","journal-title":"Eur J Gastroenterol Hepatol"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"154413","DOI":"10.1016\/j.metabol.2020.154413","article-title":"Commentary: nonalcoholic or metabolic dysfunction-associated fatty liver disease? 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Lin","year":"2020","journal-title":"Liver Int"},{"issue":"03","key":"ref6","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1016\/j.jhep.2018.10.033","article-title":"Non-alcoholic fatty liver disease - a global public health perspective","volume":"70","author":"Z M Younossi","year":"2019","journal-title":"J Hepatol"},{"issue":"04","key":"ref7","doi-asserted-by":"crossref","first-page":"896","DOI":"10.1016\/j.jhep.2018.05.036","article-title":"Modeling NAFLD disease burden in China, France, Germany, Italy, Japan, Spain, United Kingdom, and United States for the period 2016-2030","volume":"69","author":"C Estes","year":"2018","journal-title":"J Hepatol"},{"issue":"01","key":"ref8","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1002\/hep.28431","article-title":"Global epidemiology of nonalcoholic fatty liver disease-Meta-analytic assessment of prevalence, incidence, and outcomes","volume":"64","author":"Z M 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Dassanayake","year":"2009","journal-title":"J Gastroenterol Hepatol"},{"issue":"01","key":"ref59","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1186\/s12916-019-1321-x","article-title":"Risks and clinical predictors of cirrhosis and hepatocellular carcinoma diagnoses in adults with diagnosed NAFLD: real-world study of 18 million patients in four European cohorts","volume":"17","author":"M Alexander","year":"2019","journal-title":"BMC Med"},{"issue":"13","key":"ref60","doi-asserted-by":"crossref","first-page":"e0214","DOI":"10.1097\/MD.0000000000010214","article-title":"Components of metabolic syndrome increase the risk of mortality in nonalcoholic fatty liver disease (NAFLD)","volume":"97","author":"P Golabi","year":"2018","journal-title":"Medicine (Baltimore)"},{"key":"ref61","doi-asserted-by":"crossref","first-page":"679","DOI":"10.2147\/CLEP.S144368","article-title":"Clinical course of nonalcoholic fatty liver disease: an assessment of severity, progression, and 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2010 in Japan: a multicenter large retrospective study","volume":"47","author":"Y Eguchi","year":"2012","journal-title":"J Gastroenterol"},{"issue":"05","key":"ref65","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1016\/S2468-1253(19)30039-1","article-title":"Prevalence, incidence, and outcome of non-alcoholic fatty liver disease in Asia, 1999-2019: a systematic review and meta-analysis","volume":"4","author":"J Li","year":"2019","journal-title":"Lancet Gastroenterol Hepatol"},{"issue":"01","key":"ref66","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1111\/joim.13069","article-title":"Prevalence, characteristics and mortality outcomes of obese, nonobese and lean NAFLD in the United States, 1999-2016","volume":"288","author":"B Zou","year":"2020","journal-title":"J Intern Med"},{"issue":"08","key":"ref67","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1016\/S2468-1253(20)30077-7","article-title":"Global prevalence, incidence, and outcomes of non-obese or 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