{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T07:07:45Z","timestamp":1785222465963,"version":"3.55.0"},"reference-count":29,"publisher":"Georg Thieme Verlag KG","issue":"04","license":[{"start":{"date-parts":[[2023,2,2]],"date-time":"2023-02-02T00:00:00Z","timestamp":1675296000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100017531","name":"Medical and Health Research Project of Zhejiang Province","doi-asserted-by":"crossref","award":["2021KY703"],"award-info":[{"award-number":["2021KY703"]}],"id":[{"id":"10.13039\/501100017531","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100004731","name":"Natural Science Foundation of Zhejiang Province","doi-asserted-by":"crossref","award":["LQ20H180011"],"award-info":[{"award-number":["LQ20H180011"]}],"id":[{"id":"10.13039\/501100004731","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ultraschall Med"],"published-print":{"date-parts":[[2023,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n            Objectives Preoperative differentiation between benign parotid tumors (BPT) and malignant parotid tumors (MPT) is crucial for treatment decisions. The purpose of this study was to investigate the benefits of combining contrast-enhanced ultrasound (CEUS) and strain elastography (SE) for preoperative differentiation between BPT and MPT.<\/jats:p><jats:p>\n            Methods A total of 115 patients with BPT (n=72) or MPT (n=43) who underwent ultrasound (US), SE, and CEUS were enrolled. US and CEUS features and the elasticity score were evaluated. Receiver operating characteristic curve (ROC) analysis was used to assess the diagnostic performance of SE, CEUS, and SE + CEUS with respect to identifying MPT from BPT.<\/jats:p><jats:p>\n            Results Solitary presentation, larger diameter, irregular shape, ill-defined margin, heterogeneous echogenicity, and calcification on US and higher elasticity score on SE had a significant association with malignancy. MPT also presented an unclear margin, larger size after enhancement, and \u201cfast-in and fast-out\u201d pattern on CEUS. The combination of SE and CEUS was effective for differentiating MPT from BPT (AUC: 0.88, 0.80\u20130.95), with a sensitivity of 86.0%, specificity of 88.9%, and accuracy of 87.8%, which were significantly higher than the values for SE (AUC: 0.75, 0.66\u20130.85) and CEUS (AUC: 0.82, 0.73\u20130.91) alone.<\/jats:p><jats:p>\n            Conclusion The combination of CEUS and SE is valuable for distinguishing MPT from BPT.<\/jats:p>","DOI":"10.1055\/a-1866-4633","type":"journal-article","created":{"date-parts":[[2023,2,2]],"date-time":"2023-02-02T23:44:50Z","timestamp":1675381490000},"page":"419-427","source":"Crossref","is-referenced-by-count":7,"title":["Contrast-Enhanced Ultrasound and Strain Elastography for Differentiating Benign and Malignant Parotid Tumors"],"prefix":"10.1055","volume":"44","author":[{"given":"Liuhong","family":"Shi","sequence":"additional","affiliation":[{"name":"Department of Ultrasound in Medicine, Zhejiang University School of Medicine Second Affiliated Hospital, Hangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dingting","family":"Wu","sequence":"additional","affiliation":[{"name":"Nutrition Division, The Fourth Affiliated Hospital Zhejiang University School of Medicine, Yiwu, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xu","family":"Yang","sequence":"additional","affiliation":[{"name":"Pathology, Zhejiang University School of Medicine First Affiliated Hospital, Hangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caoxin","family":"Yan","sequence":"additional","affiliation":[{"name":"Department of Ultrasound in Medicine, Zhejiang University School of Medicine Second Affiliated Hospital, Hangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pintong","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Ultrasound in Medicine, Zhejiang University School of Medicine Second Affiliated Hospital, 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