{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,7,4]],"date-time":"2022-07-04T23:11:20Z","timestamp":1656976280618},"reference-count":10,"publisher":"Georg Thieme Verlag KG","issue":"13","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dtsch Med Wochenschr"],"published-print":{"date-parts":[[2022,7]]},"abstract":"<jats:title>Zusammenfassung<\/jats:title><jats:p>\n          Zusammenfassung\u2002Die Langerhans-Zell-Histiozytose ist eine seltene inflammatorische Knochenmarks-Neoplasie, die h\u00e4ufig Knochen, Lunge, Haut und Hypophyse bef\u00e4llt. Aufgrund der vielf\u00e4ltigen Klinik wird die Diagnose meist sp\u00e4t gestellt.<\/jats:p><jats:p>\n          Anamnese\u2002Eine 54-j\u00e4hrige Patientin klagte \u00fcber Ohrenschmerzen rechts seit 5 Monaten. Wegen \u00e4hnlicher Beschwerden wurde vor 3 Jahren bereits eine Mastoidektomie durchgef\u00fchrt. Die Histologie ergab damals eine unspezifische Entz\u00fcndung. Neu aufgetreten war eine Polydipsie.<\/jats:p><jats:p>\n          Untersuchungen und Diagnose\u2002Die Computertomografie der Schl\u00e4fenbeine ergab Osteolysen im Mastoid. In der Magnetresonanztomografie und Knochenszintigrafie wurden diese Ver\u00e4nderungen als uncharakteristisch entz\u00fcndlich gewertet. Die Polydipsie erwies sich im Durstversuch als Symptom eines zentralen Diabetes insipidus. Schlie\u00dflich gelang durch die Remastoidektomie der histologische Nachweis einer Langerhans-Zell-Histiozytose.<\/jats:p><jats:p>\n          Therapie und Verlauf\u2002Die Patientin erhielt neben einer systemischen Chemotherapie mit Cytarabin noch Denosumab und Desmopressin.<\/jats:p><jats:p>\n          Folgerung\u2002Eine Langerhans-Zell-Histiozytose mit Befall von Sch\u00e4delknochen geht h\u00e4ufig mit einem Diabetes insipidus einher. Das Wissen um diese typische Konstellation kann zu einer rascheren Diagnosefindung f\u00fchren und so die Prognose verbessern.<\/jats:p>","DOI":"10.1055\/a-1869-0732","type":"journal-article","created":{"date-parts":[[2022,7,4]],"date-time":"2022-07-04T22:36:28Z","timestamp":1656974188000},"page":"855-857","source":"Crossref","is-referenced-by-count":0,"title":["Eine Patientin mit Ohrenschmerzen Polyurie und Polydipsie"],"prefix":"10.1055","volume":"147","author":[{"given":"Nora","family":"Bidner","sequence":"additional","affiliation":[{"name":"1. Medizinische Abteilung mit Diabetologie, Endokrinologie und Nephrologie und Karl Landsteiner Institut f\u00fcr Adipositas und Stoffwechselerkrankungen, Klinik Landstra\u00dfe, Wien"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christoph","family":"Schnack","sequence":"additional","affiliation":[{"name":"1. Medizinische Abteilung mit Diabetologie, Endokrinologie und Nephrologie und Karl Landsteiner Institut f\u00fcr Adipositas und Stoffwechselerkrankungen, Klinik Landstra\u00dfe, Wien"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Johanna M.","family":"Brix","sequence":"additional","affiliation":[{"name":"1. Medizinische Abteilung mit Diabetologie, Endokrinologie und Nephrologie und Karl Landsteiner Institut f\u00fcr Adipositas und Stoffwechselerkrankungen, Klinik Landstra\u00dfe, Wien"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bernhard","family":"Ludvik","sequence":"additional","affiliation":[{"name":"1. Medizinische Abteilung mit Diabetologie, Endokrinologie und Nephrologie und Karl Landsteiner Institut f\u00fcr Adipositas und Stoffwechselerkrankungen, Klinik Landstra\u00dfe, Wien"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2022,7,4]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.20425","article-title":"Risk factors for diabetes insipidus in Langerhans cell histiocytosis","author":"N Crois","year":"2006","journal-title":"Pediatr Blood Cancer"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2010-04-279083","article-title":"Recurrent BRAF mutations in Langerhans cell histiocytosis","author":"G Badalian-Very","year":"2010","journal-title":"Blood"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-pathol-020712-163959","article-title":"Pathogenesis of langerhans cell histiocytosis","author":"G Badalian-Very","year":"2013","journal-title":"Annu Rev Pathol Mech Dis"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2016-01-690636","article-title":"Revised classification of histiocytoses and neoplasms of the macrophage-dendritic cell lineages","author":"J F Emile","year":"2016","journal-title":"Blood"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2009.11.014","article-title":"Histiocytic Disorders: Recent Insights into Pathophysiology and Practical Guidelines","author":"A Filipovich","year":"2010","journal-title":"Biol Blood Marrow Transplant"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"883","DOI":"10.1046\/J.1365-2141.1999.01777.X","article-title":"Familial clustering of Langerhans cell histiocytosis","volume":"107","author":"M Aric\u00f2","year":"1999","journal-title":"Br J Haematol"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1186\/1750-1172-8-72","article-title":"Management of adult patients with Langerhans cell histiocytosis: Recommendations from an expert panel on behalf of Euro-Histio-Net","author":"M Girschikofsky","year":"2013","journal-title":"Orphanet J Rare Dis"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016\/S0959-8049(03)00672-5","article-title":"Langerhans cell histiocytosis in adults: Report from the International Registry of the Histiocyte Society","author":"M Aric\u00f2","year":"2003","journal-title":"Eur J Cancer"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2003.12.030","article-title":"Endocrine involvement in pediatric-onset Langerhans\u2019 cell histiocytosis: A population-based study","author":"J Donadieu","year":"2004","journal-title":"J\u00a0Pediatr"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1210\/jcem.85.4.6501","article-title":"Hypothalamo-pituitary abnormalities in adult patients with Langerhans cell histiocytosis: Clinical, endocrinological, and radiological features and response to treatment","author":"G A Kaltsas","year":"2000","journal-title":"J Clin Endocrinol Metab"}],"container-title":["DMW - Deutsche Medizinische Wochenschrift"],"original-title":[],"language":"de","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/a-1869-0732.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,7,4]],"date-time":"2022-07-04T22:37:35Z","timestamp":1656974255000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/a-1869-0732"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,7]]},"references-count":10,"journal-issue":{"issue":"13","published-online":{"date-parts":[[2022,7,4]]},"published-print":{"date-parts":[[2022,7]]}},"URL":"https:\/\/doi.org\/10.1055\/a-1869-0732","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["0012-0472","1439-4413"],"issn-type":[{"value":"0012-0472","type":"print"},{"value":"1439-4413","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,7]]}}}