{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T18:21:43Z","timestamp":1787682103052,"version":"build-2784847793"},"reference-count":50,"publisher":"Georg Thieme Verlag KG","issue":"06","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pharmacopsychiatry"],"published-print":{"date-parts":[[2022,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Introduction An increasing number of studies are examining the link\n                    between the endocannabinoidome and major depressive disorder (MDD). We conducted\n                    an exploratory analysis of this system to identify potential markers of\n                    treatment outcomes.<\/jats:p>\n                  <jats:p>Methods The dataset of the Canadian Biomarker Integration Network in\n                    Depression-1 study, consisting of 180 patients with MDD treated for eight weeks\n                    with escitalopram followed by eight weeks with escitalopram alone or augmented\n                    with aripiprazole was analyzed. Association between response Montgomery-Asberg\n                    Depression Rating Scale (MADRS; score reduction\u226550%) or\n                    remission (MADRS score\u226410) at weeks 8 and 16 and single nucleotide\n                    polymorphisms (SNPs), methylation, and mRNA levels of 33 endocannabinoid markers\n                    were examined. A standard genome-wide association studies protocol was used for\n                    identifying SNPs, and logistic regression was used to assess methylation and\n                    mRNA levels.<\/jats:p>\n                  <jats:p>Results Lower methylation of CpG islands of the diacylglycerol lipase\n                    alpha gene (DAGLA) was associated with non-remission at week 16\n                        (DAGLA; OR=0.337, p&lt;0.003, q=0.050).\n                    Methylation of DAGLA was correlated with improvement in Clinical Global\n                    Impression (p=0.026), Quick Inventory of Depressive Symptomatology\n                    (p=0.010), and Snaith-Hamilton Pleasure scales (p=0.028). We did\n                    not find any association between SNPs or mRNA levels and treatment outcomes.<\/jats:p>\n                  <jats:p>Discussion Methylation of DAGLA is a promising candidate as a\n                    marker of treatment outcomes for MDD and needs to be explored further.<\/jats:p>","DOI":"10.1055\/a-1872-0844","type":"journal-article","created":{"date-parts":[[2022,7,6]],"date-time":"2022-07-06T18:44:17Z","timestamp":1657133057000},"page":"297-303","source":"Crossref","is-referenced-by-count":5,"title":["Identification of Endocannabinoid Predictors of Treatment Outcomes in\n                    Major Depressive Disorder: A Secondary Analysis of the First Canadian Biomarker\n                    Integration Network in Depression (CAN-BIND 1) Study"],"prefix":"10.1055","volume":"55","author":[{"given":"Helena K.","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Temerty Faculty of Medicine, University of\n                    Toronto, Toronto, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gwyneth","family":"Zai","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Temerty Faculty of Medicine, University of\n                    Toronto, Toronto, Canada"},{"name":"Campbell Family Mental Health Research Institute, Centre for Addiction\n                    and Mental Health, Toronto, Canada"},{"name":"Institute of Medical Science, Faculty of Medicine, University of\n                    Toronto, Toronto, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel J.","family":"M\u00fcller","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Temerty Faculty of Medicine, University of\n                    Toronto, Toronto, Canada"},{"name":"Campbell Family Mental Health Research Institute, Centre for Addiction\n                    and Mental Health, Toronto, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammad I.","family":"Husain","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Temerty Faculty of Medicine, University of\n                    Toronto, Toronto, Canada"},{"name":"Campbell Family Mental Health Research Institute, Centre for Addiction\n                    and Mental Health, Toronto, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raymond W.","family":"Lam","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, University of British Columbia, Vancouver,\n                    Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benicio N.","family":"Frey","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Behavioural Neurosciences, McMaster\n                    University, Hamilton, Canada"},{"name":"Mood Disorders Program and Women\u2019s Health Concerns Clinic, St.\n                    Joseph\u2019s Healthcare, Hamilton, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudio N.","family":"Soares","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Queen\u2019s university School of\n                    Medicine, Kingston, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sagar V.","family":"Parikh","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, University of Michigan, Ann Arbor, United\n                    States of America"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roumen","family":"Milev","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Queen\u2019s university School of\n                    Medicine, Kingston, Canada"},{"name":"Department of Psychiatry, Providence care, Kingston,\n                    Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jane A.","family":"Foster","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Behavioural Neurosciences, McMaster\n                    University, Hamilton, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gustavo","family":"Turecki","sequence":"additional","affiliation":[{"name":"Douglas Institute, Department of Psychiatry, McGill University,\n                    Montreal, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Faranak","family":"Farzan","sequence":"additional","affiliation":[{"name":"eBrain Lab, School of Mechatronic Systems Engineering, Simon Fraser\n                    University, Surrey, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benoit H.","family":"Mulsant","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Temerty Faculty of Medicine, University of\n                    Toronto, Toronto, Canada"},{"name":"Campbell Family Mental Health Research Institute, Centre for Addiction\n                    and Mental Health, Toronto, Canada"},{"name":"Institute of Medical Science, Faculty of Medicine, University of\n                    Toronto, Toronto, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sidney H.","family":"Kennedy","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Temerty Faculty of Medicine, University of\n                    Toronto, Toronto, Canada"},{"name":"Institute of Medical Science, Faculty of Medicine, University of\n                    Toronto, Toronto, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shreejoy J.","family":"Tripathy","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Temerty Faculty of Medicine, University of\n                    Toronto, Toronto, Canada"},{"name":"Campbell Family Mental Health Research Institute, Centre for Addiction\n                    and Mental Health, Toronto, Canada"},{"name":"Institute of Medical Science, Faculty of Medicine, University of\n                    Toronto, Toronto, Canada"},{"name":"Krembil Center for Neuroinformatics, Centre for Addiction and Mental\n                    Health, Toronto, Canada"},{"name":"Department of Physiology, University of Toronto, Toronto,\n                    Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Kloiber","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Temerty Faculty of Medicine, University of\n                    Toronto, Toronto, Canada"},{"name":"Campbell Family Mental Health Research Institute, Centre for Addiction\n                    and Mental Health, Toronto, Canada"},{"name":"Institute of Medical Science, Faculty of Medicine, University of\n                    Toronto, Toronto, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2022,7,6]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"1517","DOI":"10.1001\/jama.2017.3826","article-title":"Depression is the leading cause of disability around the world","volume":"317","author":"M J Friedrich","year":"2017","journal-title":"JAMA"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"1905","DOI":"10.1176\/ajp.2006.163.11.1905","article-title":"Acute and longer-term outcomes in depressed outpatients requiring one or several\n                    treatment steps: a STAR*D report","volume":"163","author":"A J Rush","year":"2006","journal-title":"Am J Psychiatry"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1176\/appi.ajp.163.1.28","article-title":"Evaluation of outcomes with citalopram for depression using measurement-based\n                    care in STAR*D: Implications for clinical 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Neurophysiol"}],"container-title":["Pharmacopsychiatry"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/a-1872-0844.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,25]],"date-time":"2025-11-25T21:46:51Z","timestamp":1764107211000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/a-1872-0844"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,7,6]]},"references-count":50,"journal-issue":{"issue":"06","published-online":{"date-parts":[[2022,11,8]]},"published-print":{"date-parts":[[2022,11]]}},"URL":"https:\/\/doi.org\/10.1055\/a-1872-0844","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["0176-3679","1439-0795"],"issn-type":[{"value":"0176-3679","type":"print"},{"value":"1439-0795","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,7,6]]}}}