{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T10:31:43Z","timestamp":1788517903200,"version":"build-2803163510"},"reference-count":17,"publisher":"Georg Thieme Verlag KG","issue":"09","license":[{"start":{"date-parts":[[2022,6,9]],"date-time":"2022-06-09T00:00:00Z","timestamp":1654732800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Endosc Int Open"],"published-print":{"date-parts":[[2022,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n          Background and study aims\u2002Dominant strictures (DS) occur in up to 60\u200a% of patients with primary sclerosing cholangitis (PSC). Data regarding the long-term effects of stenting vs. dilation remain limited. The aim of this study was to compare the two treatment modalities in terms of transplantation-free survival.<\/jats:p><jats:p>\n          Patients and methods\u2002This single-center, retrospective study examined patients with PSC and DS treated endoscopically with a minimum of 1 year follow-up.\u200aPatients were divided into two cohorts: 1) those who received dilation alone; and 2) those who received both dilation and stenting. The primary outcome was transplantation-free survival, defined as time after index ERCP to liver transplantation.<\/jats:p><jats:p>\n          Results\u2002In all, 169 patients (54 in dilation cohort, 115 in stenting cohort) were included. The stenting cohort had a significantly higher Mayo PSC Risk Score (1.8\u200a\u00b1\u200a1.1 vs. 0.9\u200a\u00b1\u200a1.2) and presented with cholangitis more frequently (22.6\u200a% vs. 1.9\u200a%). During a follow-up period of 1198 person-years, 69 (40.8\u200a%) patients received transplantation at a mean of 3.4 (\u00b1 2.9) years. There was no difference in transplantation rate in the stenting cohort [68 (95\u200a% CI 5.2\u20138.8) per 100 person-years] compared to the dilation cohort [3.7 (95\u200a% CI 2.1\u20136.0) per 100 person-years] and no difference in risk for transplantation (dilation cohort adjusted hazards ratio 0.67, 95\u200a% CI 0.33\u20131.32).<\/jats:p><jats:p>\n          Conclusions\u2002Despite a higher Mayo Risk Score in the stenting group, there was no difference in transplantation-free survival between patients managed with stenting vs. dilation alone. Stenting, therefore, may offer benefit in patients with advanced PSC and DS.<\/jats:p>","DOI":"10.1055\/a-1873-0961","type":"journal-article","created":{"date-parts":[[2022,6,9]],"date-time":"2022-06-09T22:57:08Z","timestamp":1654815428000},"page":"E1163-E1168","source":"Crossref","is-referenced-by-count":3,"title":["Benefit of endoscopic stenting for dominant strictures in patients with primary sclerosing cholangitis"],"prefix":"10.1055","volume":"10","author":[{"given":"Samuel","family":"Han","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Hepatology, and Nutrition. The Ohio State University Wexner Medical Center, Columbus, Ohio, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raj J.","family":"Shah","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology, University of Colorado Anschutz Medical Campus, Aurora, Colorado, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2022,9,14]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"1161","DOI":"10.1056\/NEJMra1506330","article-title":"Primary sclerosing cholangitis","volume":"375","author":"K N Lazaridis","year":"2016","journal-title":"N Engl J Med"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"1356","DOI":"10.1136\/gutjnl-2018-317993","article-title":"British Society of Gastroenterology and UK-PSC guidelines for the diagnosis and management of primary sclerosing cholangitis","volume":"68","author":"M H Chapman","year":"2019","journal-title":"Gut"},{"key":"ref3","first-page":"685","article-title":"Primary sclerosing cholangitis: clinical presentation, natural history and prognostic variables: an Italian multicentre study. The Italian PSC Study Group","volume":"8","author":"L Okolicsanyi","year":"1996","journal-title":"Europ J Gastroenterol Hepatol"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1111\/j.1572-0241.2006.00872.x","article-title":"Characterization, outcome, and prognosis in 273 patients with primary sclerosing cholangitis: A single center study","volume":"102","author":"J J Tischendorf","year":"2007","journal-title":"Am J Gastroenterol"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.1111\/j.1572-0241.2001.03690.x","article-title":"Balloon dilation compared to stenting of dominant strictures in primary sclerosing cholangitis","volume":"96","author":"M Kaya","year":"2001","journal-title":"Am J Gastroenterol"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"1265","DOI":"10.1016\/j.jhep.2017.02.013","article-title":"Role of endoscopy in primary sclerosing cholangitis: European Society of Gastrointestinal Endoscopy (ESGE) and European Association for the Study of the Liver (EASL) Clinical Guideline","volume":"66","author":"Anonymous","year":"2017","journal-title":"Journal of hepatology"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1016\/j.gie.2009.10.041","article-title":"Endoscopic dilation of dominant stenoses in primary sclerosing cholangitis: outcome after long-term treatment","volume":"71","author":"D N Gotthardt","year":"2010","journal-title":"Gastrointest Endosc"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"2403","DOI":"10.1111\/j.1572-0241.1999.01364.x","article-title":"Four years experience with short term stenting in primary sclerosing cholangitis","volume":"94","author":"C Y Ponsioen","year":"1999","journal-title":"Am J Gastroenterol"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/S0016-5107(98)70306-2","article-title":"Ten-year response to stenting in a patient with primary sclerosing cholangitis","volume":"47","author":"S E Silvis","year":"1998","journal-title":"Gastrointest Endosc"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1016\/S0016-5107(97)70123-8","article-title":"Lack of complications following short-term stent therapy for extrahepatic bile duct strictures in primary sclerosing cholangitis","volume":"46","author":"de Wit AW van Milligen","year":"1997","journal-title":"Gastrointest Endosc"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/S0016-5107(96)70167-0","article-title":"Endoscopic stent therapy for dominant extrahepatic bile duct strictures in primary sclerosing cholangitis","volume":"44","author":"AW van Milligen de Wit","year":"1996","journal-title":"Gastrointest Endosc"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"752","DOI":"10.1053\/j.gastro.2018.05.034","article-title":"No superiority of stents vs balloon dilatation for dominant strictures in patients with primary sclerosing cholangitis","volume":"155","author":"C Y Ponsioen","year":"2018","journal-title":"Gastroenterology"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"1643","DOI":"10.1002\/hep.510290607","article-title":"The relative role of the Child-Pugh classification and the Mayo natural history model in the assessment of survival in patients with primary sclerosing cholangitis","volume":"29","author":"W R Kim","year":"1999","journal-title":"Hepatology (Baltimore, Md)"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1016\/S0025-6196(11)64614-4","article-title":"A revised natural history model for primary sclerosing cholangitis","volume":"75","author":"W R Kim","year":"2000","journal-title":"Mayo Clinic Proceed"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1016\/j.gie.2014.11.019","article-title":"The role of ERCP in benign diseases of the biliary tract","volume":"81","author":"K V Chathadi","year":"2015","journal-title":"Gastrointest 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