{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T20:11:38Z","timestamp":1792181498047,"version":"4.4.0"},"reference-count":23,"publisher":"Georg Thieme Verlag KG","issue":"11","funder":[{"name":"National Institute for Health Research School for Primary Care Research"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Thromb Haemost"],"published-print":{"date-parts":[[2022,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n          Background\u2003Patients with ischemic stroke are considered a very high risk population for subsequent cardiovascular events and guidelines recommend intensive preventive strategies. However, there is no clear recommendation that patients with hemorrhagic stroke should also be regarded as a very high cardiovascular risk population.<\/jats:p><jats:p>\n          Objective\u2003To compare the risk of subsequent cardiovascular morbidity\/mortality between patients with incident hemorrhagic and ischemic stroke.<\/jats:p><jats:p>\n          Methods\u2003Patients aged \u226518 years with incident hemorrhagic or ischemic stroke between 1998 and 2017 and no prior history of serious vascular event were identified from UK Clinical Practice Research Datalink (CPRD GOLD) linked to Hospital Episode Statistics data.<\/jats:p><jats:p>\n          Results\u2003The cohort included 32,091 patients with an overall follow-up of 381,237 person-years (median: 11.8 years). After adjusting for potential confounders, patients with incident hemorrhagic stroke had no significantly different risk of subsequent cardiovascular morbidity compared with patients with incident ischemic stroke\u2014coronary heart disease (CHD; hazard ratio [HR]: 0.86, 95% confidence interval [CI]: 0.56\u20131.32), recurrent stroke (HR: 0.92, 95% CI: 0.83\u20131.02), peripheral vascular disease (PVD; HR: 1.15, 95% CI:0.56\u20132.38), or heart failure (HR: 1.03, 95% CI: 0.61\u20131.74). Patients with incident hemorrhagic stroke had significantly higher risk of subsequent cardiovascular disease (CVD)-related mortality (HR: 2.35, 95% CI: 2.04\u20132.72) and all-cause mortality (HR: 2.16, 95% CI: 1.94\u20132.41). Propensity-score matched analysis of 1,039 patients with hemorrhagic stroke and 1,039 with ischemic stroke showed similar risk in subsequent cardiovascular morbidity\u2014CHD (stratified HR [sHR]: 0.92, 95% CI: 0.55\u20131.54), recurrent stroke (sHR: 0.93, 95% CI: 0.82\u20131.02), PVD (sHR: 1.04 95% CI: 0.45\u20132.41), or heart failure (sHR: 0.71, 95% CI: 0.39\u20131.27).<\/jats:p><jats:p>\n          Conclusion\u2003The risk of subsequent cardiovascular events is similar between patients with incident hemorrhagic and ischemic stroke. Patients with previous hemorrhagic stroke should be regarded as a population at very high risk for subsequent CVD.<\/jats:p>","DOI":"10.1055\/a-1873-9092","type":"journal-article","created":{"date-parts":[[2022,6,11]],"date-time":"2022-06-11T00:13:30Z","timestamp":1654906410000},"page":"1921-1931","source":"Crossref","is-referenced-by-count":15,"title":["Comparison of Risk of Serious Cardiovascular Events after Hemorrhagic versus Ischemic Stroke: A Population-Based Study"],"prefix":"10.1055","volume":"122","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4529-8237","authenticated-orcid":false,"given":"Ralph K.","family":"Akyea","sequence":"additional","affiliation":[{"name":"Primary Care Stratified Medicine, School of Medicine, University of Nottingham, Nottingham, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7735-9474","authenticated-orcid":false,"given":"Georgios","family":"Georgiopoulos","sequence":"additional","affiliation":[{"name":"Cardiovascular Imaging, School of Biomedical Engineering and Imaging Sciences, St. Thomas Hospital, King's College London, London, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara","family":"Iyen","sequence":"additional","affiliation":[{"name":"Primary Care Stratified Medicine, School of Medicine, University of Nottingham, Nottingham, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joe","family":"Kai","sequence":"additional","affiliation":[{"name":"Primary Care Stratified Medicine, School of Medicine, University of Nottingham, Nottingham, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nadeem","family":"Qureshi","sequence":"additional","affiliation":[{"name":"Primary Care Stratified Medicine, School of Medicine, University of Nottingham, Nottingham, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George","family":"Ntaios","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Faculty of Medicine, School of Health Sciences, University of Thessaly, Larissa, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2022,9,8]]},"reference":[{"issue":"01","key":"ref1","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1093\/eurheartj\/ehz455","article-title":"2019 ESC\/EAS Guidelines for the management of dyslipidaemias: lipid modification to reduce cardiovascular risk","volume":"41","author":"F Mach","year":"2020","journal-title":"Eur Heart 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