{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T13:02:52Z","timestamp":1760101372876,"version":"3.37.3"},"reference-count":22,"publisher":"Georg Thieme Verlag KG","issue":"S 01","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am J Perinatol"],"published-print":{"date-parts":[[2024,5]]},"abstract":"<jats:p>\n            Objective\u2003Mydriatic eye drops used for retinopathy of prematurity (ROP) examination can cause systemic effects, and there are case reports of serious adverse effects in the literature. In this prospective study, we aimed to evaluate the early hemodynamic effects of mydriatic eye drops to understand the possible mechanisms of adverse effects.<\/jats:p><jats:p>\n            Study Design\u2003Between December 2018 and March 2019, preterm babies less than 32 gestational weeks and who underwent ophthalmologic examination in our unit were included. The vital signs (heart rate, respiratory rate, oxygen saturation [SpO2], and blood pressure values), cerebral and mesenteric tissue saturation by near-infrared spectroscopy (NIRS), and left ventricular functions of infants were recorded before and after applying mydriatic eye drops (2.5% phenylephrine and 0.5% tropicamide). The data were compared statistically. Strict adherence to prevent systemic absorption of the eye drops was applied.<\/jats:p><jats:p>\n            Results\u2003Thirty-two mydriasis procedures were evaluated in 26 patients. The mean gestational age was 28.5\u2009\u00b1\u20091.7 weeks, and the mean birth weight was 943\u2009\u00b1\u2009233\u2009g. There were no significant differences in terms of vital signs of infants including heart rate, blood pressure, and oxygen saturation [SpO2] levels before and after eye-drop application. In addition, NIRS values showed no significant differences between before and after measurements. No significant differences were detected at echocardiographic evaluation performed before and after mydriatic administration. No adverse reaction was observed in the study population during the study.<\/jats:p><jats:p>\n            Conclusion\u2003This is the first study that evaluated the early hemodynamic effects of mydriatic eye drops used for ROP screening by vital signs, NIRS, and echocardiographic evaluation. Mydriatic eye drops have no significant effect on early hemodynamic parameters including vital signs, NIRS, and echocardiographic findings in preterm infants. We suggest that a cautious approach for avoiding the systemic absorption of these agents may prevent the possible early systemic effects in this high-risk population.<\/jats:p><jats:p>\n            Key Points\n          <\/jats:p>","DOI":"10.1055\/a-1877-7868","type":"journal-article","created":{"date-parts":[[2022,6,17]],"date-time":"2022-06-17T22:53:48Z","timestamp":1655506428000},"page":"e324-e330","source":"Crossref","is-referenced-by-count":1,"special_numbering":"S","title":["Early Hemodynamic Effects of Mydriatic Eye Drops in Preterm Infants"],"prefix":"10.1055","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1429-3206","authenticated-orcid":false,"given":"Emre","family":"Dincer","sequence":"additional","affiliation":[{"name":"Division of Neonatology, University of Health Sciences, Zeynep Kamil Maternity and Children's Training and Research Hospital, Istanbul, T\u00fcrkiye"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ilker","family":"Gonen","sequence":"additional","affiliation":[{"name":"Department of Neonatology, Istanbul Basaksehir Cam and Sakura City Hospital, Istanbul, T\u00fcrkiye"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4012-3278","authenticated-orcid":false,"given":"Helen A.","family":"Bornaun","sequence":"additional","affiliation":[{"name":"Department of Pediatric Cardiology, University of Health Sciences, Kanuni Sultan S\u00fcleyman Research and Training Hospital, Istanbul, T\u00fcrkiye"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Beril","family":"Yasa","sequence":"additional","affiliation":[{"name":"Department of Neonatology, Istanbul Kanuni Sultan Suleyman Training and Research Hospital, Istanbul, T\u00fcrkiye"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aslan","family":"Babayigit","sequence":"additional","affiliation":[{"name":"Department of Neonatology, University of Health Sciences, Kanuni Sultan S\u00fcleyman Research and Training Hospital, Istanbul, T\u00fcrkiye"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ozge","family":"Kurum","sequence":"additional","affiliation":[{"name":"Department of Neonatology, Kanuni Sultan Suleyman Training and Research Hospital, \u0130stanbul, T\u00fcrkiye"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sad\u0131k E.","family":"Bayramo\u011flu","sequence":"additional","affiliation":[{"name":"Department of Ophtalmology, University of Health Sciences, Kanuni Sultan S\u00fcleyman Research and Training Hospital, Istanbul, T\u00fcrkiye, Istanbul, T\u00fcrkiye"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Merih","family":"Cetinkaya","sequence":"additional","affiliation":[{"name":"Department of Neonatology, Istanbul Basaksehir Cam and Sakura City Hospital, Istanbul, T\u00fcrkiye"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2022,9,2]]},"reference":[{"issue":"S 01","key":"ref1","first-page":"S151","article-title":"Turkish Neonatal and Turkish Ophthalmology Societies consensus guideline on the retinopathy of prematurity","volume":"53","author":"E Ko\u00e7","year":"2018","journal-title":"Turk Pediatri Ars"},{"issue":"12","key":"ref2","doi-asserted-by":"crossref","first-page":"1711","DOI":"10.1136\/bjophthalmol-2017-311789","article-title":"Incidence, risk factors and severity of retinopathy of prematurity in Turkey (TR-ROP study): a prospective, multicentre study in 69 neonatal intensive care units","volume":"102","author":"A Y 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