{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T08:33:53Z","timestamp":1740126833060,"version":"3.37.3"},"reference-count":26,"publisher":"Georg Thieme Verlag KG","issue":"S 01","funder":[{"name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","award":["[HD21410, HD27869, HD27915, HD27917, HD34116, HD34"],"award-info":[{"award-number":["[HD21410, HD27869, HD27915, HD27917, HD34116, HD34"]}]},{"DOI":"10.13039\/100000097","name":"National Center for Research Resources","doi-asserted-by":"crossref","award":["UL1 RR024989; 5UL1 RR025764"],"award-info":[{"award-number":["UL1 RR024989; 5UL1 RR025764"]}],"id":[{"id":"10.13039\/100000097","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am J Perinatol"],"published-print":{"date-parts":[[2024,5]]},"abstract":"<jats:p>\n            Objective\u2003This study aimed to assess the association of maternal body mass index (BMI) with a composite of severe maternal outcomes.<\/jats:p><jats:p>\n            Study Design\u2003Secondary analysis of a cohort of deliveries on randomly selected days at 25 hospitals from 2008 to 2011. Data on comorbid conditions, intrapartum events, and postpartum course were collected. The reference group (REF, BMI: 18.5\u201329.9kg\/m2), obese (OB; BMI: 30\u201339.9kg\/m2), morbidly obese (MO; BMI: 40\u201349.9kg\/m2), and super morbidly obese (SMO; BMI \u2265 50kg\/m2) women were compared. The composite of severe maternal outcomes was defined as death, intensive care unit (ICU) admission, ventilator use, deep venous thrombosis\/pulmonary embolus (DVT\/PE), sepsis, hemorrhage, disseminated intravascular coagulation (DIC), unplanned operative procedure, or stroke. Patients in the REF group were matched 1:1 with those in all other obesity groups based on propensity score using the baseline characteristics of age, race\/ethnicity, previous cesarean, preexisting diabetes, chronic hypertension, parity, cigarette use, and insurance status. Multivariable Poisson's regression was used to estimate adjusted relative risks (aRRs) and 95% confidence intervals (CIs) for the association between BMI and the composite outcome. Because cesarean delivery may be in the causal pathway between obesity and adverse maternal outcomes, models were then adjusted for mode of delivery to evaluate potential mediation.<\/jats:p><jats:p>\n            Results\u2003A total of 52,162 pregnant patients are included in the analysis. Risk of composite maternal outcomes was increased for SMO compared with REF but not for OB and MO [OB: aRR=1.06, 95% CI: 0.99\u20131.14; MO: aRR=1.10, 95% CI: 0.97\u20131.25; SMO: aRR=1.32, 95% CI: 1.02\u20131.70]. However, in the mediation analysis, cesarean appears to mediate 46% (95% CI: 31\u201350%) of the risk of severe morbidity for SMO compared with REF.<\/jats:p><jats:p>\n            Conclusion\u2003Super morbid obesity is significantly associated with increased serious maternal morbidity and mortality; however, cesarean appears to mediate this association. Obesity and morbid obesity are not associated with maternal morbidity and mortality.<\/jats:p><jats:p>\n            Key Points\n          <\/jats:p>","DOI":"10.1055\/a-1877-8918","type":"journal-article","created":{"date-parts":[[2022,6,16]],"date-time":"2022-06-16T22:36:47Z","timestamp":1655419007000},"page":"e204-e211","source":"Crossref","is-referenced-by-count":0,"special_numbering":"S","title":["Association of Maternal Body Mass Index and Maternal Morbidity And Mortality"],"prefix":"10.1055","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4643-8871","authenticated-orcid":false,"given":"Mara J.","family":"Dinsmoor","sequence":"additional","affiliation":[{"name":"Departments of Obstetrics and Gynecology of Northwestern University, Chicago, Illinois"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lynda G.","family":"Ugwu","sequence":"additional","affiliation":[{"name":"George Washington University Biostatistics Center, Washington, District of Columbia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jennifer L.","family":"Bailit","sequence":"additional","affiliation":[{"name":"Departments of Obstetrics and Gynecology, MetroHealth Medical Center-Case Western Reserve University, Cleveland, Ohio"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Uma M.","family":"Reddy","sequence":"additional","affiliation":[{"name":"The Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, Maryland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ronald J.","family":"Wapner","sequence":"additional","affiliation":[{"name":"Departments of Obstetrics and Gynecology, Columbia University, New York, New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9455-3973","authenticated-orcid":false,"given":"Michael W.","family":"Varner","sequence":"additional","affiliation":[{"name":"Departments of Obstetrics and Gynecology, University of Utah Health Sciences Center, Salt Lake City, Utah"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":"Jr.","given":"John M.","family":"Thorp","sequence":"additional","affiliation":[{"name":"Departments of Obstetrics and Gynecology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steve N.","family":"Caritis","sequence":"additional","affiliation":[{"name":"Departments of Obstetrics and Gynecology, University of Pittsburgh, Pittsburgh, Pennsylvania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mona","family":"Prasad","sequence":"additional","affiliation":[{"name":"Departments of Obstetrics and Gynecology, The Ohio State University, Columbus, Ohio"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alan T.N.","family":"Tita","sequence":"additional","affiliation":[{"name":"Departments of Obstetrics and Gynecology, University of Alabama at Birmingham, Birmingham, Alabama"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"George R.","family":"Saade","sequence":"additional","affiliation":[{"name":"Departments of Obstetrics and Gynecology, University of Texas Medical Branch, Galveston, Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoram","family":"Sorokin","sequence":"additional","affiliation":[{"name":"Departments of Obstetrics and Gynecology, Wayne State University, Detroit, Michigan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dwight J.","family":"Rouse","sequence":"additional","affiliation":[{"name":"Departments of Obstetrics and Gynecology, Brown University, Providence, Rhode Island"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sean C.","family":"Blackwell","sequence":"additional","affiliation":[{"name":"Departments of Obstetrics and Gynecology, University of Texas Health Science Center at Houston, McGovern Medical School-Children's Memorial Hermann Hospital, Houston, Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jorge E.","family":"Tolosa","sequence":"additional","affiliation":[{"name":"Departments of Obstetrics and Gynecology, Oregon Health and Science University, Portland, Oregon"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"for the Eunice Kennedy Shriver National Institute of Child Health Human Development Maternal-Fetal Medicine Units (MFMU) Network*","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2022,9,2]]},"reference":[{"issue":"03","key":"ref1","first-page":"120","article-title":"Obesity - United States, 1999-2010","volume":"62","author":"A L May","year":"2013","journal-title":"MMWR Suppl"},{"issue":"01","key":"ref2","first-page":"73","article-title":"Obesity - United States, 1988-2008","volume":"60","author":"D S Freedman","year":"2011","journal-title":"MMWR 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