{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,11,6]],"date-time":"2024-11-06T05:26:32Z","timestamp":1730870792586,"version":"3.28.0"},"reference-count":14,"publisher":"Georg Thieme Verlag KG","issue":"S 01","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am J Perinatol"],"published-print":{"date-parts":[[2024,5]]},"abstract":"<jats:p>\n            Objective\u2003This article aimed to evaluate pregnancy outcomes when a plan to perform fetal blood sampling (FBS) or delivery was based solely on the first abnormal middle cerebral artery peak velocity (MCA-PV) measurement compared with making a plan after a confirmatory test on a subsequent day.<\/jats:p><jats:p>\n            Study Design\u2003We performed a descriptive study of pregnancy outcomes including all patients in a single healthcare system with maternal red cell alloimmunization undergoing ultrasound between 2005 and 2017 who had at least one MCA-PV&gt;1.5 multiples of the median (MoM). We excluded patients with any sign of hydrops prior to the index visit or abnormal MCA-PV at&gt;35 weeks. The first exam with a MCA-PV&gt;1.5 MoM was deemed the index visit.<\/jats:p><jats:p>\n            Results\u2003Fifty patients were identified. Twenty-one patients underwent intervention (FBS or delivery) based on the first abnormal MCA-PV. Of those, 9 had moderate or severe anemia (positive predictive value [PPV]: 43%), while 12 had mild or no anemia. The other 29 patients underwent a confirmatory MCA test between 2 and 8 days later. Of these, 13 patients had an abnormal confirmatory test and 11 of these underwent FBS and 7 had moderate or severe anemia (PPV: 54%). Sixteen patients undergoing confirmatory MCA Doppler had a normal test on repeat and did not undergo FBS. Of those, none developed moderate or severe anemia.<\/jats:p><jats:p>\n            Conclusion\u2003A substantial number of patients (55%) had normal MCA-PV testing on repeat, allowing avoidance of invasive testing. Deferring FBS until the abnormal MCA-PV was confirmed was not associated with undetected moderate or severe anemia.<\/jats:p><jats:p>\n            Key Points\n          <\/jats:p>","DOI":"10.1055\/a-1877-9798","type":"journal-article","created":{"date-parts":[[2022,6,16]],"date-time":"2022-06-16T22:36:47Z","timestamp":1655419007000},"page":"e275-e281","source":"Crossref","is-referenced-by-count":0,"special_numbering":"S","title":["Confirmatory Middle Cerebral Artery Doppler Testing in Alloimmunized Patients with Suspected Fetal Anemia"],"prefix":"10.1055","volume":"41","author":[{"given":"Douglas S.","family":"Richards","sequence":"additional","affiliation":[{"name":"Division of Maternal Fetal Medicine, Intermountain Healthcare, Salt Lake City, Utah"},{"name":"Division of Maternal Fetal Medicine, University of Utah Health, Salt Lake City, Utah"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ashley E.","family":"Benson","sequence":"additional","affiliation":[{"name":"Division of Maternal Fetal Medicine, Intermountain Healthcare, Salt Lake City, Utah"},{"name":"Division of Maternal Fetal Medicine, University of Utah Health, Salt Lake City, Utah"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brett D.","family":"Einerson","sequence":"additional","affiliation":[{"name":"Division of Maternal Fetal Medicine, Intermountain Healthcare, Salt Lake City, Utah"},{"name":"Division of Maternal Fetal Medicine, University of Utah Health, Salt Lake City, Utah"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2022,9,2]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1016\/j.ajog.2015.01.059","article-title":"Society for Maternal-Fetal Medicine (SMFM) Clinical Guideline #8: the fetus at risk for anemia - diagnosis and management","volume":"212","author":"G Mari","year":"2015","journal-title":"Am J Obstet Gynecol"},{"issue":"05","key":"ref2","doi-asserted-by":"crossref","first-page":"1132","DOI":"10.1097\/AOG.0b013e31826d7dc1","article-title":"Management and prevention of red cell alloimmunization in pregnancy: a systematic review","volume":"120","author":"K J Moise Jr","year":"2012","journal-title":"Obstet Gynecol"},{"issue":"04","key":"ref3","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1159\/000328683","article-title":"Procedure-related complications and perinatal outcome after intrauterine transfusions in red cell alloimmunization in Stockholm","volume":"30","author":"E Tiblad","year":"2011","journal-title":"Fetal Diagn Ther"},{"key":"ref4","first-page":"170","article-title":"Society for Maternal Fetal Medicine (SMFM) Clinical guideline. 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