{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:47:30Z","timestamp":1788223650578,"version":"build-2803163510"},"reference-count":17,"publisher":"Georg Thieme Verlag KG","issue":"01","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Drug Res (Stuttg)"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Cardiac dysfunction such as cirrhotic cardiomyopathy is more common in liver\n                    cirrhosis related disorders including primary biliary cholangitis or biliary\n                    cirrhosis and primary sclerosing cholangitis. Bile duct ligation (BDL) is an\n                    effective model of biliary cholestasis, producing oxidative damage and fibrosis.\n                    This research was designed to evaluate the effect of Lupeol and Naringin and its\n                    combination on bile duct ligation induced cardiac injury in rats. For\n                    pharmacological evaluation, rats were randomly divided into seven groups;\n                    intrahepatic cholestasis induced by ligation of the bile duct might lead to\n                    cirrhotic cardiomyopathy. The results were analyzed by physical, biochemical and\n                    histological examination. The Lupeol (100\u2009mg\/kg, p.o.), Naringin\n                    (100\u2009mg\/kg, p.o.) and its combination (100\u2009mg\/kg\n                    each) treated group significantly improved physical infarct size, biochemical\n                    (Nitrite, SOD, CAT, and GSH) and histological (heart tissue- mitochondrial\n                    function\/integrity and fibrosis) alterations occurs due to BDL-ligation.\n                    This study was concluded that oral administration of Lupeol, Naringin, and its\n                    combination has a curative potential against BDL-induced cardiac injury in rats\n                    by reducing oxidative stress and inflammatory reactions, resulting in reduced\n                    heart necrosis\/myocardial infarction and increased myocardial activity.\n                    It also inhibits cardiac damage in the rat heart, these effects may be linked to\n                    the NO level (eNOS) is increased and the inactivation of the NF-kB-p65\n                    expression pathways.This study also provides new insights into the development\n                    of lupeol and Naringin combination that can be used as supportive therapy for\n                    cardiovascular diseases.<\/jats:p>","DOI":"10.1055\/a-1879-2944","type":"journal-article","created":{"date-parts":[[2022,9,23]],"date-time":"2022-09-23T03:57:37Z","timestamp":1663905457000},"page":"23-29","source":"Crossref","is-referenced-by-count":7,"title":["Synergetic Effect of Lupeol and Naringin Against Bile Duct Ligation\n                    Induced Cardiac Injury in Rats via Modulating Nitrite Level (eNos) and NF-kB\n                    \/p65 Expression"],"prefix":"10.1055","volume":"73","author":[{"given":"Firoj","family":"Alam","sequence":"additional","affiliation":[{"name":"Kunwar Haribansh Singh College of Pharmacy, Jaunpur, (U.P.),\n                    India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anil Kumar","family":"Kharya","sequence":"additional","affiliation":[{"name":"Kunwar Haribansh Singh College of Pharmacy, Jaunpur, (U.P.),\n                    India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ritesh Kumar","family":"Srivastav","sequence":"additional","affiliation":[{"name":"Kamla Nehru Institute of Management & Technology, Sultanpur\n                    (U.P.), India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juber","family":"Akhtar","sequence":"additional","affiliation":[{"name":"Faculty of Pharmacy Integral University, Lucknow (U.P.),\n                    India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad Irfan","family":"Khan","sequence":"additional","affiliation":[{"name":"Faculty of Pharmacy Integral University, Lucknow (U.P.),\n                    India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad","family":"Ahmad","sequence":"additional","affiliation":[{"name":"Faculty of Pharmacy Integral University, Lucknow (U.P.),\n                    India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2022,9,22]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1161\/01.CIR.0000052939.59093.45","article-title":"Markers of inflammation and cardiovascular disease: application to clinical and\n                    public health practice: a statement for healthcare professionals from the\n                    Centers for Disease Control and Prevention and the American Heart\n                    Association","volume":"107","author":"TA Pearson","year":"2003","journal-title":"Circulation"},{"key":"ref2","first-page":"505","article-title":"H. 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endotoxin-induced oxidative, inflammatory, and apoptotic\n                    responses in H9c2 cardiomyocytes","volume":"22","author":"S Zhang","year":"2018","journal-title":"Eur Rev Med Pharmacol Sci"}],"container-title":["Drug 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