{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T20:34:27Z","timestamp":1785530067725,"version":"3.56.0"},"reference-count":32,"publisher":"Georg Thieme Verlag KG","issue":"09","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Horm Metab Res"],"published-print":{"date-parts":[[2022,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Polycystic ovarian syndrome (PCOS) is a heterogenous condition accounting for\n                    serious health complications. The present study was conducted to assess the\n                    early clinical, biochemical, and radiological features in obese, non-obese young\n                    women with PCOS as compared to non-PCOS women. The study was conducted on 120\n                    young women (18\u201322 years) with 80 having features of PCOS [40 obese\n                    (BMI\u226525\u2009kg\/m2) and 40 non-obese\n                    (BMI&lt;25\u2009kg\/m2) PCOS] as cases and 40 without PCOS as\n                    controls in a rural tertiary care center of Northern India over one year\n                    (2017\u20132018). After enrolment of cases and control, the anthropometric\n                    measurements, early clinical symptoms, and biochemical and ultrasonographic\n                    features were compared between the groups. Statistical analysis was done using\n                    SPSS software version 22.0 (p-value&lt;0.05). A significant difference in\n                    anthropometric measurements were observed between obese and non-obese PCOS\n                    cases. Clinical features like acne, acanthosis nigricans, and hirsutism were\n                    more prevalent in obese PCOS as compared to non-obese and controls. On\n                    ultrasound, PCOS cases had a significantly increased number of peripherally\n                    arranged ovarian follicles, and ovarian volume. The LH: FSH ratio was\n                    significantly higher in cases as compared to controls. The levels of serum LH\n                    (10.04\u00b11.60 vs. 8.93\u00b12.40 mIU\/ml) and total testosterone\n                    (2.71\u00b10.39 vs. 2.21\u00b10.39\u2009pg\/ml) were higher in\n                    obese PCOS as compared to non-obese PCOS cases. In conclusion, clinical,\n                    biochemical, and radiological features can be used in the early diagnosis of\n                    PCOS. Obesity is an independent risk factor for PCOS and is associated with an\n                    increased risk of complications.<\/jats:p>","DOI":"10.1055\/a-1880-1264","type":"journal-article","created":{"date-parts":[[2022,7,20]],"date-time":"2022-07-20T22:47:50Z","timestamp":1658357270000},"page":"620-624","source":"Crossref","is-referenced-by-count":9,"title":["Early Clinical, Biochemical and Radiological Features in Obese and\n                    Non-Obese Young Women with Polycystic Ovarian Syndrome: A Comparative\n                    Study"],"prefix":"10.1055","volume":"54","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5970-6935","authenticated-orcid":false,"given":"Naina","family":"Kumar","sequence":"additional","affiliation":[{"name":"Obstetrics and Gynecology, All India Institute of Medical Sciences\n                    \u2013 Bibinagar, Hyderabad, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Himani","family":"Agarwal","sequence":"additional","affiliation":[{"name":"Obstetrics and Gynecology, Maharishi Markandeshwar Institute of Medical\n                    Sciences and Research, Ambala, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2022,7,20]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.3126\/nje.v11i3.38460","article-title":"Polycystic ovary syndrome among Indian adolescent girls \u2013 a systematic\n                    review and metanalysis","volume":"11","author":"M Sharma","year":"2021","journal-title":"Nepal J Epidemiol"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"12264","DOI":"10.18535\/jmscr\/v4i11.119","article-title":"Awareness about PCOS and the likelihood of its symptoms in adolescent girls in a\n                    semi-urban set-up: a cross sectional study","volume":"4","author":"P Rajkumari","year":"2016","journal-title":"J Med Sci Clin Res"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"96351","DOI":"10.18632\/oncotarget.19180","article-title":"The prevalence of polycystic ovary syndrome in reproductive-aged women of\n                    different ethnicity: a systematic review and meta-analysis","volume":"8","author":"T Ding","year":"2017","journal-title":"Oncotarget"},{"key":"ref4","first-page":"533","article-title":"The prevalence of polycystic ovary syndrome in adolescents: a systematic review\n                    and meta-analysis","volume":"17","author":"MS G Naz","year":"2019","journal-title":"Int J Reprod Biomed"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"1545","DOI":"10.1210\/js.2019-00078","article-title":"Polycystic ovary syndrome: pathophysiology, presentation, and treatment with\n                    emphasis on adolescent girls","volume":"3","author":"S F Witchel","year":"2019","journal-title":"J Endocr Soc"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.5772\/intechopen.89961","volume-title":"Clinical features of PCOS. 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and their differential response to\n                    clomiphene","volume":"23","author":"G Sachdeva","year":"2019","journal-title":"Indian J Endocrinol Metab"},{"key":"ref24","first-page":"317","article-title":"Acanthosis nigricansin PCOS Patients and its relation with type 2 diabetes\n                    mellitus and body mass at a tertiary care hospital in Southern India","volume":"7","author":"G Shivaprakas","year":"2013","journal-title":"J Clin Diagn Res"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"419","DOI":"10.4103\/0019-5154.160505","article-title":"Correlation of skin changes with hormonal changes in polycystic ovarian\n                    syndrome: a cross-sectional clinical study","volume":"60","author":"B V Gowri","year":"2015","journal-title":"Indian J Dermatol"},{"key":"ref26","first-page":"260","article-title":"Insulin resistance and adverse metabolic profile in overweight\/obese and\n                    normal weight of young women with polycystic 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Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/a-1880-1264.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,9,7]],"date-time":"2022-09-07T23:36:43Z","timestamp":1662593803000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/a-1880-1264"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,7,20]]},"references-count":32,"journal-issue":{"issue":"09","published-online":{"date-parts":[[2022,9,7]]},"published-print":{"date-parts":[[2022,9]]}},"URL":"https:\/\/doi.org\/10.1055\/a-1880-1264","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["0018-5043","1439-4286"],"issn-type":[{"value":"0018-5043","type":"print"},{"value":"1439-4286","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,7,20]]}}}