{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,22]],"date-time":"2026-03-22T05:11:56Z","timestamp":1774156316759,"version":"3.50.1"},"reference-count":30,"publisher":"Georg Thieme Verlag KG","issue":"09","funder":[{"name":"Basic Research Project of Natural Science Fund of Shaanxi Province","award":["2016JQ8026"],"award-info":[{"award-number":["2016JQ8026"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Horm Metab Res"],"published-print":{"date-parts":[[2022,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>In in vitro fertilization (IVF), it is meaningful to find novel biomarkers predicting ovarian response in advance. The aim of the study was to identify serum metabolomics predicting ovarian response after controlled ovarian stimulation (COS). Blood samples collected at the start of pituitary downregulation and on the fifth day after COS using Liquid chromatography-tandem mass spectrometry (LC-MS\/MS) methods were analyzed to quantify metabolites. Demographic data were calculated with SPSS version 22.0 software. Multivariate statistics were used to analyze metabolomics dataset. A receiver operating characteristic (ROC) curve was used to evaluate the diagnostic model. Analyses revealed 50 different metabolomics between the pre- and post-COS groups. Compared with baseline, amino acids increased significantly following COS. At baseline, acetylglycine was more abundant in FOI&lt;1 group, while glycine and lipids increased in FOI\u22651 group. After COS, glycine, N-acetyl-L-alanine, D-alanine, and 2-aminomuconic acid were higher in those with FOI\u22651, but L-glutamine was abundant in FOI&lt;1. ROC curves indicated that combination of glycine, acetylglycine, and lipids predicts different responses to COS (AUC=0.866). Serum metabolism might reflect the response to ovarian stimulation. Higher glycine and PC may be a good predictor for response to COS.<\/jats:p>","DOI":"10.1055\/a-1882-3967","type":"journal-article","created":{"date-parts":[[2022,6,22]],"date-time":"2022-06-22T22:43:55Z","timestamp":1655937835000},"page":"625-632","source":"Crossref","is-referenced-by-count":3,"title":["Serum Metabolomic Signature Predicts Ovarian Response to Controlled Stimulation"],"prefix":"10.1055","volume":"54","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0413-9045","authenticated-orcid":false,"given":"Xin","family":"Mu","sequence":"first","affiliation":[{"name":"Center for Translational Medicine, Xi'an Jiaotong University Medical College First Affiliated Hospital, Xi'an, China"},{"name":"Assistant Reproductive Center, Northwest Women and Children's Hospital, Xi'an, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mei-li","family":"Pei","sequence":"first","affiliation":[{"name":"Department of Gynecology and Obstetrics, Xi'an Jiaotong University Medical College First Affiliated Hospital, Xi'an, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Feng","family":"Zhu","sequence":"additional","affiliation":[{"name":"Center for Translational Medicine, Xi'an Jiaotong University Medical College First Affiliated Hospital, Xi'an, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan Zi","family":"Shi","sequence":"additional","affiliation":[{"name":"Assistant Reproductive Center, Northwest Women and Children's Hospital, Xi'an, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peijun","family":"Liu","sequence":"additional","affiliation":[{"name":"Center for Translational Medicine, Xi'an Jiaotong University Medical College First Affiliated Hospital, Xi'an, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2022,9,7]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"959","DOI":"10.3906\/sag-1905-179","article-title":"Ovarian stimulation modalities in poor responders","volume":"49","author":"Z S Ozkan","year":"2019","journal-title":"Turk J Med Sci"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"S46","DOI":"10.1080\/1464727022000199921","article-title":"Poor ovarian response to gonadotrophin stimulation the role of adjuvant treatments","volume":"5","author":"SD Keay","year":"2002","journal-title":"Hum Fertil (Camb)"},{"key":"ref3","first-page":"352098","article-title":"Management of poor responders in IVF: is there anything new?","author":"F Ubaldi","year":"2014","journal-title":"Biomed Res Int"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1093\/humupd\/dmt037","article-title":"Individualization of controlled ovarian stimulation in IVF using ovarian reserve markers: from theory to practice","volume":"20","author":"A La Marca","year":"2014","journal-title":"Hum Reprod Update"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1093\/humrep\/deq361","article-title":"Serum anti-Mullerian hormone levels are negatively related to Follicular Output RaTe (FORT) in normo-cycling women undergoing controlled ovarian hyperstimulation","volume":"26","author":"V K Genro","year":"2011","journal-title":"Hum Reprod"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"589","DOI":"10.3389\/fendo.2018.00589","article-title":"Understanding ovarian hypo-response to exogenous gonadotropin in ovarian stimulation and its new proposed marker \u2013 the follicle-to-oocyte (FOI) index","volume":"9","author":"C Alviggi","year":"2018","journal-title":"Front Endocrinol (Lausanne)"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1080\/19396368.2018.1478469","article-title":"Metabolomics analysis of follicular fluid in women with ovarian endometriosis undergoing in vitro fertilization","volume":"65","author":"A Karaer","year":"2019","journal-title":"Syst Biol Reprod Med"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"80472","DOI":"10.18632\/oncotarget.19058","article-title":"Follicular metabolic changes and effects on oocyte quality in polycystic ovary syndrome patients","volume":"8","author":"Y Zhang","year":"2017","journal-title":"Oncotarget"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"986997","DOI":"10.1002\/mrd.23415","article-title":"Relationship between the metabolic and lipid profile in follicular fluid of women undergoing in vitro fertilization","volume":"87","author":"S Luti","year":"2020","journal-title":"Mol Reprod Dev"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1186\/1741-7015-10-153","article-title":"Metabolic profiles characterizing different phenotypes of polycystic ovary syndrome: plasma metabolomics analysis","volume":"10","author":"Y Zhao","year":"2012","journal-title":"BMC Med"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"181","DOI":"10.3389\/fendo.2020.00181","article-title":"Follicular output rate and follicle-to-oocyte index of low prognosis patients according to POSEIDON criteria: a retrospective cohort study of 32,128 treatment cycles","volume":"11","author":"L Chen","year":"2020","journal-title":"Front Endocrinol (Lausanne)"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"1066","DOI":"10.1093\/humrep\/der479","article-title":"Antral follicle responsiveness to follicle-stimulating hormone administration assessed by the Follicular Output RaTe (FORT) may predict in vitro fertilization-embryo transfer outcome","volume":"27","author":"V Gallot","year":"2012","journal-title":"Hum Reprod"},{"key":"ref13","first-page":"323","article-title":"Serum metabolites as predictive molecular markers of ovarian response to controlled stimulation: a pilot study","volume":"23","author":"E Borges","year":"2019","journal-title":"JBRA Assist Reprod"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"1716701","DOI":"10.1155\/2017\/1716701","article-title":"Multifarious beneficial effect of nonessential amino acid, glycine: a review","author":"M A Razak","year":"2017","journal-title":"Oxid Med Cell Longev"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"1594","DOI":"10.1210\/jc.2004-0317","article-title":"Low serine hydroxymethyltransferase activity in the human placenta has important implications for fetal glycine supply","volume":"90","author":"R M Lewis","year":"2005","journal-title":"J Clin Endocrinol Metab"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"833","DOI":"10.2337\/dc15-2251","article-title":"Metabolomics in prediabetes and diabetes: a systematic review and meta-analysis","volume":"39","author":"M Guasch-Ferre","year":"2016","journal-title":"Diabetes Care"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1007\/s00726-017-2508-0","article-title":"Insulin resistance and glycine metabolism in humans","volume":"50","author":"M Adeva-Andany","year":"2018","journal-title":"Amino Acids"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1186\/s12986-018-0325-4","article-title":"Association of serum glycine levels with metabolic syndrome in an elderly Chinese population","volume":"15","author":"X Li","year":"2018","journal-title":"Nutr Metab (Lond)"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1530\/REP-09-0345","article-title":"The pivotal role of glucose metabolism in determining oocyte developmental competence","volume":"139","author":"M L Sutton-McDowall","year":"2010","journal-title":"Reproduction"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1262\/jrd.2019-102","article-title":"Energy metabolism of follicular environment during oocyte growth and maturation","volume":"66","author":"E Warzych","year":"2020","journal-title":"J Reprod Dev"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"8152","DOI":"10.1002\/jcp.27603","article-title":"Insulin resistance: review of the underlying molecular mechanisms","volume":"234","author":"H Yaribeygi","year":"2019","journal-title":"J Cell Physiol"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1038\/nature13478","article-title":"The role of hepatic lipids in hepatic insulin resistance and type 2 diabetes","volume":"510","author":"R J 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Cataldi","year":"2013","journal-title":"Hum Fertil (Camb)"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1007\/s10815-014-0375-0","article-title":"Follicular fluid lipid fingerprinting from women with PCOS and hyper response during IVF treatment","volume":"32","author":"F B Cordeiro","year":"2015","journal-title":"J Assist Reprod Genet"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"1289","DOI":"10.1007\/s10815-012-9859-y","article-title":"The follicular microenviroment as a predictor of pregnancy: MALDI-TOF MS lipid profile in cumulus cells","volume":"29","author":"D A Montani","year":"2012","journal-title":"J Assist Reprod Genet"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1007\/s11306-018-1350-z","article-title":"Hyper response to ovarian stimulation affects the follicular fluid metabolomic profile of women undergoing IVF similarly to polycystic ovary syndrome","volume":"14","author":"F B 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