{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T07:18:54Z","timestamp":1792739934393,"version":"4.5.0"},"reference-count":19,"publisher":"Georg Thieme Verlag KG","issue":"S 01","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am J Perinatol"],"published-print":{"date-parts":[[2024,5]]},"abstract":"<jats:p>\n            Objective\u2003This study aimed to determine whether a trial of labor after cesarean section (TOLAC) with a macrosomic neonate is associated with adverse outcomes.<\/jats:p><jats:p>\n            Study Design\u2003A retrospective cohort study was conducted in a population motivated for TOLAC. Women attempting TOLAC with a neonatal birth weight &gt;4,000\u2009g were compared with women attempting TOLAC with neonatal birth weights between 3,500 and 4,000\u2009g. The primary outcome was TOLAC success. Secondary outcomes included mode of delivery, uterine rupture, postpartum hemorrhage (PPH), shoulder dystocia, obstetric anal sphincter injury (OASI), Apgar's score &lt;7 at 5\u2009minutes, and umbilical artery pH &lt;7.1. Data were analyzed using Fisher's exact test and Chi\u2010square test.<\/jats:p><jats:p>\n            Results\u2003Overall, 375 women who underwent TOLAC with a neonate weighing &gt;4,000\u2009g comprised the study group. One thousand seven hundred and eighty-three women attempting TOLAC with a neonate weighing 3,500 to 4,000\u2009g comprised the control group. There were no clinically significant differences between the groups for maternal age, gestational age, parity, and vaginal birth after cesarean (VBAC) rate. There were no significant differences in the rates of successful TOLAC (94 vs. 92.3%, p\u2009=\u20090.2, odds ratio [OR]\u2009=\u20090.8, 95% confidence interval [CI]: 0.5, 1.2), operative vaginal delivery (7.4 vs. 5.3%, p\u2009=\u20090.18, OR\u2009=\u20090.7, 95% CI: 0.4, 1.1), uterine rupture (0.4 vs. 0%, p\u2009=\u20090.6), PPH (3.2 vs. 2.3%, p\u2009=\u20090.36, OR\u2009=\u20091.4, 95% CI: 0.7, 2.7), OASI (0.8 vs. 0.2%, p\u2009=\u20090.1, OR\u2009=\u20093.6, 95% CI: 0.8, 1.6), Apgar's score &lt;7 at 5\u2009minutes (0 vs. 0.4%, p\u2009=\u20090.37), and umbilical artery pH &lt;7.1 (0.5 vs. 0.7%, p\u2009=\u20091.0, OR\u2009=\u20090.73, 95% CI: 0.2, 3.2). Women with a neonate weighing &gt;4,000\u2009g had a significantly increased risk of shoulder dystocia (4 vs. 0.4%, p\u2009&lt;\u20090.05, OR\u2009=\u20099.2 95% CI: 3.9, 22)<\/jats:p><jats:p>\n            Conclusion\u2003Women attempting TOLAC with a macrosomic neonate are not at increased risk for failed TOLAC, operative vaginal delivery, uterine rupture, PPH, or OASI but are at risk of shoulder dystocia. This information may aid in prenatal counseling for women considering TOLAC with a macrosomic fetus.<\/jats:p><jats:p>\n            Key Points\n          <\/jats:p>","DOI":"10.1055\/a-1884-1221","type":"journal-article","created":{"date-parts":[[2022,6,24]],"date-time":"2022-06-24T23:13:41Z","timestamp":1656112421000},"page":"e400-e405","source":"Crossref","is-referenced-by-count":5,"special_numbering":"S","title":["A Trial of Labor after Cesarean Section with a Macrosomic Neonate. Is It Safe?"],"prefix":"10.1055","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5304-2296","authenticated-orcid":false,"given":"Miriam","family":"Lopian","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Mayanei Hayeshua Medical Center, Bnei Brak, Israel"},{"name":"Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lior","family":"Kashani-Ligumski","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Mayanei Hayeshua Medical Center, Bnei Brak, Israel"},{"name":"Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronnie","family":"Cohen","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Mayanei Hayeshua Medical Center, Bnei Brak, Israel"},{"name":"Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacky","family":"Herzlich","sequence":"additional","affiliation":[{"name":"Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel"},{"name":"Department of Neonatology, Lis Hospital for Women, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sharon","family":"Perlman","sequence":"additional","affiliation":[{"name":"Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel"},{"name":"Prenatal Ultrasound Unit The Helen Schneider Hospital for Women, Rabin Medical Center, Beilinson Campus, Petach Tikva, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2022,9,16]]},"reference":[{"issue":"06","key":"ref1","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1007\/s00404-008-0630-7","article-title":"The influence of macrosomia on the duration of labor, the mode of 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Apropos of 355 cases [in French]","volume":"29","author":"A Aboulfalah","year":"2000","journal-title":"J Gynecol Obstet Biol Reprod (Paris)"},{"issue":"02","key":"ref15","doi-asserted-by":"crossref","first-page":"e110","DOI":"10.1097\/AOG.0000000000003078","article-title":"ACOG practice bulletin no. 205: vaginal birth after cesarean delivery","volume":"133","author":"ACOG Practice Bulletin No","year":"2019","journal-title":"Obstet Gynecol"},{"issue":"01","key":"ref17","doi-asserted-by":"crossref","first-page":"89","DOI":"10.3109\/14767058.2013.806474","article-title":"Clinical accuracy of estimated fetal weight in term pregnancies in a teaching hospital","volume":"27","author":"K R Goetzinger","year":"2014","journal-title":"J Matern Fetal Neonatal Med"},{"issue":"05","key":"ref18","doi-asserted-by":"crossref","first-page":"546.e1","DOI":"10.1016\/j.ajog.2021.07.019","article-title":"Normal labor curve in twin gestation","volume":"225","author":"H Hochler","year":"2021","journal-title":"Am J Obstet Gynecol"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1097\/AOG.0b013e31816102b9","article-title":"Labor outcomes with increasing number of prior vaginal births after cesarean delivery","volume":"111","author":"B M Mercer","year":"2008","journal-title":"Obstet Gynecol"},{"issue":"04","key":"ref20","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1111\/j.1600-0412.2011.01354.x","article-title":"Risk of shoulder dystocia: associations with parity and offspring birthweight. A population study of 1 914 544 deliveries","volume":"91","author":"E A Overland","year":"2012","journal-title":"Acta Obstet Gynecol Scand"}],"container-title":["American Journal of Perinatology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/a-1884-1221.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,5]],"date-time":"2024-11-05T13:11:09Z","timestamp":1730812269000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/a-1884-1221"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,6,24]]},"references-count":19,"journal-issue":{"issue":"S 01","published-online":{"date-parts":[[2024,5,13]]},"published-print":{"date-parts":[[2024,5]]}},"URL":"https:\/\/doi.org\/10.1055\/a-1884-1221","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["0735-1631","1098-8785"],"issn-type":[{"value":"0735-1631","type":"print"},{"value":"1098-8785","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2022,6,24]]},"published":{"date-parts":[[2022,6,24]]}}}