{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,2]],"date-time":"2026-11-02T19:15:52Z","timestamp":1793646952221,"version":"4.5.1"},"reference-count":27,"publisher":"Georg Thieme Verlag KG","issue":"02","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Endoscopy"],"published-print":{"date-parts":[[2023,2]]},"abstract":"<jats:p>Background\u2002The long-term outcomes of esophageal peroral endoscopic myotomy (POEM) are still unknown.<\/jats:p>\n                  <jats:p>Methods\u2002We searched electronic databases (MEDLINE\/PubMed, EMBASE, Scopus) for studies assessing outcomes after POEM for esophageal achalasia with a minimum median follow-up duration of 36 months. Pooled rates of clinical success and postoperative reflux were calculated and compared with the same values at 12\/24\/36 months when available. Subgroup analyses were performed to explore the interstudy heterogeneity.<\/jats:p>\n                  <jats:p>Results\u2002From 1528 initial records, 11 studies (2017\u20132021) were included. A total of 2342 patients (age 48.1 [SD 6.8] years; 50.1\u200a% males) with a median follow-up of 48 months (interquartile range 45\u201360) were analyzed. The pooled clinical success rate was 87.3\u200a% (95\u200a%CI 83.6\u200a%\u201391.0\u200a%; I2 \u200a=\u200a73.1\u200a%). The symptomatic reflux pooled rate was 22.0\u200a% (95\u200a%CI 14.4\u200a%\u201329.5\u200a%; I2 \u200a=\u200a92.7\u200a%). Three cases of peptic strictures and one Barrett\u2019s esophagus were reported. The pooled rate of severe adverse events was 1.5\u200a% (95\u200a%CI 0.5\u200a%\u20132.5\u200a%; I2 \u200a=\u200a52.8\u200a%).<\/jats:p>\n                  <jats:p>Conclusions\u2002Long-term clinical efficacy of POEM persisted in 87\u200a% of patients with achalasia. Post-POEM symptomatic reflux remained stable over time. The risk for Barrett\u2019s esophagus and peptic strictures appeared minimal.<\/jats:p>","DOI":"10.1055\/a-1894-0147","type":"journal-article","created":{"date-parts":[[2022,7,7]],"date-time":"2022-07-07T20:01:52Z","timestamp":1657224112000},"page":"167-175","source":"Crossref","is-referenced-by-count":63,"title":["Long-term outcomes of peroral endoscopic myotomy for achalasia: a systematic review and meta-analysis"],"prefix":"10.1055","volume":"55","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5573-447X","authenticated-orcid":false,"given":"Edoardo","family":"Vespa","sequence":"first","affiliation":[{"name":"Department of Gastroenterology and Hepatology, IRCCS Humanitas Research Hospital, Rozzano, Milan, Italy"},{"name":"Department of Biomedical Sciences, Humanitas University, Pieve Emanuele, Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gaia","family":"Pellegatta","sequence":"first","affiliation":[{"name":"Department of Gastroenterology and Hepatology, IRCCS Humanitas Research Hospital, Rozzano, Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5256-4113","authenticated-orcid":false,"given":"Viveksandeep T.","family":"Chandrasekar","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology, Mayo Clinic, Phoenix, Arizona, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Spadaccini","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology, IRCCS Humanitas Research Hospital, Rozzano, Milan, Italy"},{"name":"Department of Biomedical Sciences, Humanitas University, Pieve Emanuele, Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harsh","family":"Patel","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Ochsner Clinic Foundation, New Orleans, Louisiana, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberta","family":"Maselli","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology, IRCCS Humanitas Research Hospital, Rozzano, Milan, Italy"},{"name":"Department of Biomedical Sciences, Humanitas University, Pieve Emanuele, Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Piera A.","family":"Galtieri","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology, IRCCS Humanitas Research Hospital, Rozzano, Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisa","family":"Carlani","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology, IRCCS Humanitas Research Hospital, Rozzano, Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prateek","family":"Sharma","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology, Kansas City VA Medical Center, Kansas City, Missouri, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cesare","family":"Hassan","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology, IRCCS Humanitas Research Hospital, Rozzano, Milan, Italy"},{"name":"Department of Biomedical Sciences, Humanitas University, Pieve Emanuele, Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandro","family":"Repici","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology, IRCCS Humanitas Research Hospital, Rozzano, Milan, Italy"},{"name":"Department of Biomedical Sciences, Humanitas University, Pieve Emanuele, Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2022,8,31]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1055\/s-0029-1244080","article-title":"Peroral endoscopic myotomy (POEM) for esophageal achalasia","volume":"42","author":"H Inoue","year":"2010","journal-title":"Endoscopy"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1177\/2050640615581732","article-title":"Systematic review and meta-analysis: efficacy and safety of POEM for achalasia","volume":"3","author":"L A Barbieri","year":"2015","journal-title":"United Eur Gastroenterol J"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1136\/gutjnl-2014-308649","article-title":"Clinical response to peroral endoscopic myotomy in patients with idiopathic achalasia at a minimum follow-up of 2 years","volume":"65","author":"Y B Werner","year":"2016","journal-title":"Gut"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"1293","DOI":"10.1007\/s00464-017-5807-3","article-title":"Per-oral endoscopic myotomy (POEM): mid-term efficacy and safety","volume":"32","author":"J Martinek","year":"2018","journal-title":"Surg Endosc"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"1959","DOI":"10.1016\/j.cgh.2021.04.033","article-title":"Landscape of adverse events related to peroral endoscopic myotomy in 3135 patients and a risk-scoring system to predict major adverse events","volume":"19","author":"X Liu","year":"2021","journal-title":"Clin Gastroenterol Hepatol"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"934","DOI":"10.1016\/j.gie.2017.10.022","article-title":"GERD after per-oral endoscopic myotomy as compared with Heller\u2019s myotomy with fundoplication: a systematic review with meta-analysis","volume":"87","author":"A Repici","year":"2018","journal-title":"Gastrointest Endosc"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1055\/a-1133-4354","article-title":"Gastroesophageal reflux disease after peroral endoscopic myotomy is unpredictable, but responsive to proton pump inhibitor therapy: a large, single-center study","volume":"52","author":"Z Nabi","year":"2020","journal-title":"Endoscopy"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1177\/2050640620903213","article-title":"European guidelines on achalasia: United European Gastroenterology and European Society of Neurogastroenterology and Motility recommendations","volume":"8","author":"RAB Oude Nijhuis","year":"2020","journal-title":"United Eur Gastroenterol J"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"2219","DOI":"10.1056\/NEJMoa1905380","article-title":"Endoscopic or surgical myotomy in patients with idiopathic achalasia","volume":"381","author":"Y B Werner","year":"2019","journal-title":"N Engl J Med"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"n71","DOI":"10.1136\/bmj.n71","article-title":"The PRISMA 2020 statement: an updated guideline for reporting systematic reviews","volume":"372","author":"M J Page","year":"2021","journal-title":"BMJ"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/dote\/dow011","article-title":"Long-term outcomes of peroral endoscopic myotomy for patients with achalasia: a retrospective single-center study","volume":"30","author":"H Guo","year":"2017","journal-title":"Dis Esophagus"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"E650","DOI":"10.1055\/a-1120-8125","article-title":"Long-term outcomes of per-oral endoscopic myotomy in achalasia patients with a minimum follow-up of 4 years: a multicenter study","volume":"8","author":"OI Brewer Gutierrez","year":"2020","journal-title":"Endosc Int open"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"792","DOI":"10.1007\/s00464-020-07450-6","article-title":"Long-term outcomes of per-oral endoscopic myotomy compared to laparoscopic Heller myotomy for achalasia: a single-center experience","volume":"35","author":"A J Podboy","year":"2021","journal-title":"Surg Endosc"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1007\/s10620-018-5373-0","article-title":"Long-term efficacy of peroral endoscopic myotomy for patients with achalasia: outcomes with a median follow-up of 36 months","volume":"64","author":"C He","year":"2019","journal-title":"Dig Dis Sci"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.gie.2019.07.036","article-title":"A risk-scoring system to predict clinical failure for patients with achalasia after peroral endoscopic myotomy","volume":"91","author":"X-Y Liu","year":"2020","journal-title":"Gastrointest Endosc"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"5709","DOI":"10.1007\/s00464-020-08031-3","article-title":"POEM: clinical outcomes beyond 5 years","volume":"35","author":"S C McKay","year":"2021","journal-title":"Surg Endosc"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"1209","DOI":"10.1055\/s-0043-117401","article-title":"Long-term quality of life after peroral endoscopic myotomy remains compromised in patients with achalasia type III","volume":"49","author":"OV Hern\u00e1ndez Mondrag\u00f3n","year":"2017","journal-title":"Endoscopy"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1097\/MCG.0000000000001395","article-title":"Long-term outcomes of per-oral endoscopic myotomy in spastic esophageal motility disorders: a large, single-center study","volume":"55","author":"Z Nabi","year":"2021","journal-title":"J Clin Gastroenterol"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1007\/s00464-017-5699-2","article-title":"Clinical outcomes five years after POEM for treatment of primary esophageal motility disorders","volume":"32","author":"E N Teitelbaum","year":"2018","journal-title":"Surg Endosc"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"1135","DOI":"10.1097\/SLA.0000000000004830","article-title":"Outcomes of 100 patients more than 4 years after poem for achalasia","volume":"273","author":"R AJ Campagna","year":"2021","journal-title":"Ann Surg"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"996","DOI":"10.1097\/CM9.0000000000000735","article-title":"Long-term outcomes of peroral endoscopic myotomy in achalasia patients with a minimum follow-up of 7 years","volume":"133","author":"W-G Zhang","year":"2020","journal-title":"Chin Med J (Engl)"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1097\/SLE.0b013e31825a2478","article-title":"Medium and long-term outcomes after pneumatic dilation or laparoscopic Heller myotomy for achalasia: a meta-analysis","volume":"22","author":"C E Weber","year":"2012","journal-title":"Surg Laparosc Endosc Percutan Tech"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"732","DOI":"10.1136\/gutjnl-2015-310602","article-title":"Long-term results of the European achalasia trial: a multicentre randomised controlled trial comparing pneumatic dilation versus laparoscopic Heller myotomy","volume":"65","author":"A Moonen","year":"2016","journal-title":"Gut"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1097\/SLA.0000000000002311","article-title":"Laparoscopic Heller myotomy versus peroral endoscopic myotomy (POEM) for achalasia: a systematic review and meta-analysis","volume":"267","author":"F Schlottmann","year":"2018","journal-title":"Ann Surg"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"1436","DOI":"10.1111\/jgh.14097","article-title":"Management of achalasia cardia: expert consensus statements","volume":"33","author":"M Ramchandani","year":"2018","journal-title":"J Gastroenterol Hepatol"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"E1097","DOI":"10.1055\/a-1483-9406","article-title":"Peroral endoscopic myotomy (POEM) vs pneumatic dilation (PD) in treatment of achalasia: a meta-analysis of studies with \u226512-month follow-up","volume":"9","author":"A Ofosu","year":"2021","journal-title":"Endosc Int Open"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1136\/gutjnl-2020-320772","article-title":"Reflux symptoms and oesophageal acidification in treated achalasia patients are often not reflux related","volume":"70","author":"F A Ponds","year":"2021","journal-title":"Gut"}],"container-title":["Endoscopy"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/a-1894-0147.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,24]],"date-time":"2023-11-24T04:38:11Z","timestamp":1700800691000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/a-1894-0147"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,7,7]]},"references-count":27,"journal-issue":{"issue":"02","published-online":{"date-parts":[[2023,1,26]]},"published-print":{"date-parts":[[2023,2]]}},"URL":"https:\/\/doi.org\/10.1055\/a-1894-0147","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["0013-726X","1438-8812"],"issn-type":[{"value":"0013-726X","type":"print"},{"value":"1438-8812","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2022,7,7]]},"published":{"date-parts":[[2022,7,7]]}}}