{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T00:36:57Z","timestamp":1774571817763,"version":"3.50.1"},"reference-count":15,"publisher":"Georg Thieme Verlag KG","issue":"01","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neuropediatrics"],"published-print":{"date-parts":[[2023,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n          Introduction\u2003Various neurologic manifestations have already been described in children during or after severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections. The central nervous system disorders reported in children are mainly encephalopathies during multisystem inflammatory syndrome. We present here an acute meningoencephalitis with cerebral vasculitis associated to a coronavirus disease 2019 (COVID-19) infection in a 13-year-old girl with a 1-year clinical, electroencephalogram (EEG), and magnetic resonance imaging (MRI) follow-up.<\/jats:p><jats:p>\n          Case Report\u2003A 13-year-old girl presented acute symptoms of consciousness impairment, frontal headache, hyperthermia, and aphasia, with moderate lymphopenia (900\/mm3), elevated C-reactive protein (17\u2009mg\/L), cerebrospinal fluid (CSF) pleocytosis (15 cells\/mm3), slow background with frontal focalization on EEG, a left frontal ischemic lesion, leptomeningeal enhancement, and bilateral limbic fluid-attenuated inversion recovery hyperintensity on cerebral MRI. Reverse transcription-polymerase chain reaction for SARS-CoV-2 was positive in nasopharyngeal swab and COVID serology was positive for immunoglobulin (Ig) M and G, whereas extensive autoimmune antibody investigation was negative except for a positive low titer of anti-myelin oligodendrocyte glycoprotein in CSF and blood. The diagnosis of probable encephalitis associated to cerebral vasculitis after COVID infection was suggested and steroids pulse were started. She recovered within a few days. Six months later, she had moderate clinical sequels including persistent intermittent headaches, an isolated spatial deficit, and focal spikes on the EEG without argument for epilepsia.<\/jats:p><jats:p>\n          Conclusion\u2003A teenager without previous medical history presented with acute encephalitis with leptomeningitis and vasculitis after a recent COVID-19 infection. Steroids pulse therapy allowed clinical improvement. Cerebral MRI and EEG helped diagnosis, follow-up of the encephalitis, and evolution after treatment.<\/jats:p>","DOI":"10.1055\/a-1896-6154","type":"journal-article","created":{"date-parts":[[2022,7,11]],"date-time":"2022-07-11T23:16:20Z","timestamp":1657581380000},"page":"068-072","source":"Crossref","is-referenced-by-count":4,"title":["Acute Corticosteroid Responsive Meningoencephalitis with Cerebral Vasculitis after COVID-19 Infection in a Thirteen-Year-Old"],"prefix":"10.1055","volume":"54","author":[{"given":"Gr\u00e2ce","family":"Fran\u00e7ois","sequence":"additional","affiliation":[{"name":"Clinical Neurophysiology Department, Lille University Hospital, Lille, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pierre","family":"Cleuziou","sequence":"additional","affiliation":[{"name":"Department of Pediatric Neurology, Lille University Hospital, Lille, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Quentin","family":"Vannod-Michel","sequence":"additional","affiliation":[{"name":"Neuroradiology Department, Lille University Hospital, Lille, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philippe","family":"Derambure","sequence":"additional","affiliation":[{"name":"Clinical Neurophysiology Department, Lille University Hospital, Lille, France"},{"name":"INSERM U1171, University of Lille, Lille, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sylvie","family":"Nguyen-The-Tich","sequence":"additional","affiliation":[{"name":"Department of Pediatric Neurology, Lille University Hospital, Lille, France"},{"name":"CHU Lille, ULR2694-METRICS, University of Lille, Lille, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1984-015X","authenticated-orcid":false,"given":"Laurence","family":"Chaton","sequence":"additional","affiliation":[{"name":"Clinical Neurophysiology Department, Lille University Hospital, Lille, France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2022,12,23]]},"reference":[{"issue":"09","key":"ref1","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1016\/S1474-4422(20)30221-0","article-title":"Neurological associations of COVID-19","volume":"19","author":"M A Ellul","year":"2020","journal-title":"Lancet Neurol"},{"issue":"05","key":"ref2","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1001\/jamaneurol.2021.0504","article-title":"Neurologic involvement in children and adolescents hospitalized in the United States for COVID-19 or multisystem inflammatory syndrome","volume":"78","author":"K L 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