{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,25]],"date-time":"2025-11-25T14:10:06Z","timestamp":1764079806497,"version":"3.37.3"},"reference-count":21,"publisher":"Georg Thieme Verlag KG","issue":"01","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neuropediatrics"],"published-print":{"date-parts":[[2023,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Anti-Hu encephalitis is a paraneoplastic syndrome in adults. In children, rare cases of anti-Hu encephalitis were reported mostly without underlying tumors and clinical outcome are usually severe. Here, we describe a 4-year-old girl who developed cerebellar syndrome with abnormal behavior. The brain magnetic resonance imaging showed several T2\/fluid-attenuated inversion recovery bilateral brain lesions and autoimmune assessment showed positive anti-Hu antibodies. Computed tomography scan revealed ganglioneuroblastoma which was surgically removed 3 months after onset. Aggressive immunotherapy including dexamethasone, rituximab, and intravenous immunoglobulins were used and a marked neurological improvement soon after 9 months of onset was observed with the child being able to go back to school. The short delay between diagnosis and start of aggressive immunotherapy demonstrate the paramount importance of early diagnosis and early specific therapy after onset of symptoms.<\/jats:p>","DOI":"10.1055\/a-1896-6687","type":"journal-article","created":{"date-parts":[[2022,7,11]],"date-time":"2022-07-11T23:16:20Z","timestamp":1657581380000},"page":"064-067","source":"Crossref","is-referenced-by-count":3,"title":["Early and Aggressive Treatment May Modify Anti-Hu Associated Encephalitis Prognosis"],"prefix":"10.1055","volume":"54","author":[{"given":"Perrine","family":"Marion","sequence":"additional","affiliation":[{"name":"Pediatric Neurology Department, Bic\u00eatre Hospital, Assistance Publique-H\u00f4pitaux de Paris, H\u00f4pitaux Universitaires Paris Saclay, Le Kremlin Bic\u00eatre, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ali\u00e9nor De","family":"Chalus","sequence":"additional","affiliation":[{"name":"Pediatric Neurology Department, Bic\u00eatre Hospital, Assistance Publique-H\u00f4pitaux de Paris, H\u00f4pitaux Universitaires Paris Saclay, Le Kremlin Bic\u00eatre, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laetitia","family":"Giorgi","sequence":"additional","affiliation":[{"name":"Pediatric Neurology Department, Bic\u00eatre Hospital, Assistance Publique-H\u00f4pitaux de Paris, H\u00f4pitaux Universitaires Paris Saclay, Le Kremlin Bic\u00eatre, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C\u00e9line","family":"Bellesme","sequence":"additional","affiliation":[{"name":"Pediatric Neurology Department, Bic\u00eatre Hospital, Assistance Publique-H\u00f4pitaux de Paris, H\u00f4pitaux Universitaires Paris Saclay, Le Kremlin Bic\u00eatre, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pascale","family":"Cr\u00e9tien","sequence":"additional","affiliation":[{"name":"Pediatric Neurology Department, Bic\u00eatre Hospital, Assistance Publique-H\u00f4pitaux de Paris, H\u00f4pitaux Universitaires Paris Saclay, Le Kremlin Bic\u00eatre, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H\u00e9l\u00e8ne","family":"Maurey","sequence":"additional","affiliation":[{"name":"Pediatric Neurology Department, Bic\u00eatre Hospital, Assistance Publique-H\u00f4pitaux de Paris, H\u00f4pitaux Universitaires Paris Saclay, Le Kremlin Bic\u00eatre, France"},{"name":"Pediatric Neurologic Department, National Referral Center for Rare Brain and Spinal Diseases, Le Kremlin-Bic\u00eatre, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8409-2365","authenticated-orcid":false,"given":"Kumaran","family":"Deiva","sequence":"additional","affiliation":[{"name":"Pediatric Neurology Department, Bic\u00eatre Hospital, Assistance Publique-H\u00f4pitaux de Paris, H\u00f4pitaux Universitaires Paris Saclay, Le Kremlin Bic\u00eatre, France"},{"name":"Pediatric Neurologic Department, National Referral 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