{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T20:10:17Z","timestamp":1787170217410,"version":"build-2736575974"},"reference-count":31,"publisher":"Georg Thieme Verlag KG","issue":"09","license":[{"start":{"date-parts":[[2022,9,14]],"date-time":"2022-09-14T00:00:00Z","timestamp":1663113600000},"content-version":"vor","delay-in-days":13,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Endosc Int Open"],"published-print":{"date-parts":[[2022,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Background and study aims\u2002Obtaining quality tissue during ERCP biliary stricture sampling is of paramount importance for a timely diagnosis. While single-operator cholangioscopy (SOC)-guided biopsies have been suggested to be the superior biliary tissue acquisition modality given direct tissue visualization, less is known about the specimen histological quality. We aimed to analyze the specimen quality of SOC biopsies and compare the new generation forceps with prior \u201clegacy\u201d forceps.<\/jats:p>\n                  <jats:p>Patients and methods\u2002Patients who underwent SOC from January 2017-August 2021 for biliary sampling were reviewed. In February 2020, the SOC-guided biopsy forceps were changed from legacy SpyBite to the SpyBite Max forceps (max). Specimens were assessed by blinded pathologists for crush artifact (none, mild, or severe) and gross size (greatest dimension in mm). Crush artifact and gross size were compared between the two groups. The diagnostic performance characteristics for cholangiocarcinoma (CCA), were assessed in an exploratory fashion.<\/jats:p>\n                  <jats:p>Results\u2002Eighty-one patients (max\u200a=\u200a27, legacy\u200a=\u200a54) with similar baseline characteristics were included in this study. On blinded pathological assessment, 58\u200a% had crush artifact, without significant differences between the two groups (Max 63\u200a% vs. Legacy 56\u200a%; P\u200a=\u200a0.64). A similar mean specimen size was found (max 3\u200amm vs. legacy 3.2 mm; P\u200a=\u200a0.24). The overall prevalence of CCA was 40\u200a%. The sensitivity, specificity, positive predictive value, and negative predictive value of the entire cohort using a combination of cytology, fluorescence in situ hybridization, and SOC-guided biopsies were 78.1\u200a%, 91.8\u200a%, 86.2\u200a%, and 86.5\u200a%, respectively. No difference between legacy or max groups was found.<\/jats:p>\n                  <jats:p>Conclusions\u2002A high rate of crush artifact was found in SOC-guided biopsy specimens. Further investigation regarding proper biopsy technique and handling is necessary to increase the diagnostic yield with SOC-guided biopsies.<\/jats:p>","DOI":"10.1055\/a-1897-4686","type":"journal-article","created":{"date-parts":[[2022,9,14]],"date-time":"2022-09-14T18:48:31Z","timestamp":1663181311000},"page":"E1233-E1237","source":"Crossref","is-referenced-by-count":9,"title":["Histological assessment of new cholangioscopy-guided forceps in ERCP biliary stricture sampling: a blinded comparative study"],"prefix":"10.1055","volume":"10","author":[{"given":"Eric J.","family":"Vargas","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology, Mayo Clinic Rochester, Rochester, Minnesota, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaohong","family":"Wang","sequence":"additional","affiliation":[{"name":"Vanderbilt University School of Medicine, Pathology, Microbiology and Immunology, Nashville, Tennessee, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zongming Eric","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Pathology, Mayo Clinic Rochester, Rochester, Minnesota, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rami","family":"Abusaleh","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology, Mayo Clinic Rochester, Rochester, Minnesota, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew C.","family":"Storm","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology, Mayo Clinic Rochester, Rochester, Minnesota, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John A.","family":"Martin","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology, Mayo Clinic Rochester, Rochester, Minnesota, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryan J.","family":"Law","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology, Mayo Clinic Rochester, Rochester, Minnesota, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barham K. Abu","family":"Dayyeh","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology, Mayo Clinic Rochester, Rochester, Minnesota, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael J.","family":"Levy","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology, Mayo Clinic Rochester, Rochester, Minnesota, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bret","family":"Petersen","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology, Mayo Clinic Rochester, Rochester, Minnesota, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vinay","family":"Chandrasekhara","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology, Mayo Clinic Rochester, Rochester, Minnesota, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2022,9,14]]},"reference":[{"key":"ref1","first-page":"67","article-title":"The management of biliary strictures","volume":"24","author":"B T Petersen","year":"2012","journal-title":"Dig Endosc"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1002\/hep.1840120421","article-title":"Diagnostic value of brush cytology in the diagnosis of bile duct carcinoma: A study in 65 patients with bile duct strictures","volume":"12","author":"M Rabinovitz","year":"1990","journal-title":"Hepatology"},{"key":"ref3","first-page":"577","article-title":"A prospective, controlled analysis of endoscopic cytotechniques for diagnosis of malignant biliary strictures","volume":"86","author":"P G Foutch","year":"1991","journal-title":"Am J Gastroenterol"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"1399","DOI":"10.1002\/hep.1840180618","article-title":"A 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