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This makes scientists figure out how to control\n                    oxidative stress and chronic inflammation at the molecular level. Nuclear factor\n                    erythroid 2- related factor 2 (Nrf2) releases antioxidant proteins to suppress\n                    reactive oxygen species (ROS) activation and inflammation. The current review\n                    discusses the role of Nrf2 in improving diabetic wound healing by reducing the\n                    production of ROS and thus reducing oxidative stress, as well as inhibiting\n                    nuclear factor kappa B (NF-kB) dissociation and nuclear translocation, which\n                    prevents the release of inflammatory mediators and increases antioxidant protein\n                    levels, thereby improving diabetic wound healing. As a result, the researcher\n                    will be able to find a more effective diabetic wound healing therapy.<\/jats:p>","DOI":"10.1055\/a-1899-8233","type":"journal-article","created":{"date-parts":[[2022,8,5]],"date-time":"2022-08-05T22:38:17Z","timestamp":1659739097000},"page":"487-495","source":"Crossref","is-referenced-by-count":12,"title":["Nrf2 Mediated Heme Oxygenase-1 Activation Contributes to Diabetic\n                    Wound Healing \u2013 an Overview"],"prefix":"10.1055","volume":"72","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7927-4554","authenticated-orcid":false,"given":"Vadivelan","family":"Ramachandran","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, JSS College of Pharmacy, JSS Academy of\n                    Higher Education & Research, Ooty, The Nilgiris, Tamilnadu,\n                    India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tharani","family":"Mohanasundaram","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, JSS College of Pharmacy, JSS Academy of\n                    Higher Education & Research, Ooty, The Nilgiris, Tamilnadu,\n                    India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruchi","family":"Tiwari","sequence":"additional","affiliation":[{"name":"Pranveer Singh institute of Technology (Pharmacy), Kanpur \u2013\n                    Agra \u2013 Delhi, NH2, Bhauti, Kanpur, Uttar Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gaurav","family":"Tiwari","sequence":"additional","affiliation":[{"name":"Pranveer Singh institute of Technology (Pharmacy), Kanpur \u2013\n                    Agra \u2013 Delhi, NH2, Bhauti, Kanpur, Uttar Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Putta","family":"Vijayakumar","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Practice, JSS College of Pharmacy, JSS Academy\n                    of Higher Education & Research, Ooty, The Nilgiris, Tamilnadu,\n                    India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bhargav","family":"Bhongiri","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Practice, JSS College of Pharmacy, JSS Academy\n                    of Higher Education & Research, Ooty, The Nilgiris, Tamilnadu,\n                    India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rinu Mary","family":"Xavier","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Practice, JSS College of Pharmacy, JSS Academy\n                    of Higher Education & Research, Ooty, The Nilgiris, Tamilnadu,\n                    India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2022,8,5]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"2085","DOI":"10.3390\/ijms17122085","article-title":"Inflammation in chronic wounds","volume":"17","author":"R Zhao","year":"2016","journal-title":"Int J Mol Sci"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"665","DOI":"10.1152\/physrev.00067.2017","article-title":"Wound healing: A cellular perspective","volume":"99","author":"M Rodrigues","year":"2019","journal-title":"Physiol Rev"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1590\/abd1806-4841.20164741","article-title":"Wound healing \u2013 A literature review","volume":"91","author":"ACD O Gonzalez","year":"2016","journal-title":"An Bras Dermatol"},{"key":"ref4","first-page":"9","article-title":"Advances and Impact of Antioxidant Hydrogel in Chronic Wound Healing","author":"Z Xu","year":"2020","journal-title":"Adv Healthc Mater"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1111\/iwj.12557","article-title":"Reactive oxygen species (ROS) and wound healing: the functional role of ROS and\n                    emerging ROS-modulating technologies for augmentation of the healing\n                    process","volume":"14","author":"C Dunnill","year":"2017","journal-title":"Int Wound J"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1016\/j.jval.2017.07.007","article-title":"An Economic Evaluation of the Impact, Cost, and Medicare Policy Implications of\n                    Chronic Nonhealing Wounds","volume":"21","author":"S R Nussbaum","year":"2018","journal-title":"Value Heal"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"S17","DOI":"10.2337\/dc22-S002","article-title":"2. 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